-
Notifications
You must be signed in to change notification settings - Fork 15
Commit
This commit does not belong to any branch on this repository, and may belong to a fork outside of the repository.
- Loading branch information
1 parent
74b9809
commit 5f1cf6f
Showing
1 changed file
with
91 additions
and
0 deletions.
There are no files selected for viewing
This file contains bidirectional Unicode text that may be interpreted or compiled differently than what appears below. To review, open the file in an editor that reveals hidden Unicode characters.
Learn more about bidirectional Unicode characters
| Original file line number | Diff line number | Diff line change |
|---|---|---|
| @@ -0,0 +1,91 @@ | ||
| --- | ||
| annotations: | ||
| - id: DOID:2841 | ||
| type: Disease Ontology | ||
| value: asthma | ||
| - id: CL:0002598 | ||
| parent: native cell | ||
| type: Cell Type Ontology | ||
| value: bronchial smooth muscle cell | ||
| - id: PW:0000754 | ||
| parent: drug pathway | ||
| type: Pathway Ontology | ||
| value: drug pathway | ||
| - id: PW:0001022 | ||
| parent: disease pathway | ||
| type: Pathway Ontology | ||
| value: asthma pathway | ||
| authors: | ||
| - Eweitz | ||
| citedin: '' | ||
| communities: [] | ||
| description: '"A model for the molecular synergy between β2-agonists and GCs in modulating | ||
| airway inflammation and bronchoconstriction in asthma. Glucocorticoids mediate their | ||
| cellular responses by activating cytosolic GRα or mGR. The genomic effects of GCs | ||
| modulate gene expression, which can typically take hours to occur. In contrast, | ||
| GCs can also have nongenomic effects, which occur immediately or within minutes. | ||
| GCs can also enhance cAMP generation induced by β2-agonists that can then inhibit | ||
| a variety of procontractile signaling events to reverse bronchoconstriction." From | ||
| Figure 1 in https://www.sciencedirect.com/science/article/pii/S2213219824001454.' | ||
| last-edited: 2024-12-14 | ||
| ndex: null | ||
| organisms: | ||
| - Homo sapiens | ||
| redirect_from: | ||
| - /index.php/Pathway:WP5503 | ||
| - /instance/WP5503 | ||
| - /instance/WP5503_r136076 | ||
| revision: r136076 | ||
| schema-jsonld: | ||
| - '@context': https://schema.org/ | ||
| '@id': https://wikipathways.github.io/pathways/WP5503.html | ||
| '@type': Dataset | ||
| creator: | ||
| '@type': Organization | ||
| name: WikiPathways | ||
| description: '"A model for the molecular synergy between β2-agonists and GCs in | ||
| modulating airway inflammation and bronchoconstriction in asthma. Glucocorticoids | ||
| mediate their cellular responses by activating cytosolic GRα or mGR. The genomic | ||
| effects of GCs modulate gene expression, which can typically take hours to occur. | ||
| In contrast, GCs can also have nongenomic effects, which occur immediately or | ||
| within minutes. GCs can also enhance cAMP generation induced by β2-agonists that | ||
| can then inhibit a variety of procontractile signaling events to reverse bronchoconstriction." From | ||
| Figure 1 in https://www.sciencedirect.com/science/article/pii/S2213219824001454.' | ||
| keywords: | ||
| - ADCY1 | ||
| - ADCY2 | ||
| - ADCY3 | ||
| - ADCY4 | ||
| - ADCY5 | ||
| - ADCY6 | ||
| - ADCY7 | ||
| - ADCY8 | ||
| - ADCY9 | ||
| - ADRB2 | ||
| - ATP | ||
| - Albuterol | ||
| - Budesonide | ||
| - CREB1 | ||
| - GNAS | ||
| - MYL1 | ||
| - MYL2 | ||
| - MYL3 | ||
| - MYL4 | ||
| - NR3C1 | ||
| - PLCB1 | ||
| - PLCB2 | ||
| - PLCB3 | ||
| - PLCB4 | ||
| - PRKACA | ||
| - PRKACB | ||
| - PRKAR1A | ||
| - PRKAR1B | ||
| - PRKAR2A | ||
| - PRKAR2B | ||
| - cAMP | ||
| license: CC0 | ||
| name: Albuterol and budesonide therapy for asthma | ||
| seo: CreativeWork | ||
| title: Albuterol and budesonide therapy for asthma | ||
| wpid: WP5503 | ||
| --- |