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Ulli just asked about this stale branch. (I picked up work from 2011 and made it work again, but that was already nearly a year ago.) The big picture of this branch is described in detail(!) in issue #33.
Let's use this PR to discuss what needs to be done to include this (after releasing 1.11.0).
If I remember correctly, I was not fully happy with this yet, but one of the reasons might just have been that the z resolution (which is most likely to differ from x/y) is not present in our TIFFs at all (since they're always accompanied by a DICOM file together with all the medical information). But that should not block inclusion of tiled TIFF reading in VIGRA.
Also, this is for the readVolume() API only, ATM. OTOH, there are some useful cleanups and helper classes involved that could also be used for the 2D loader, which could eventually be extended as well.