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add 'best' DFE from Kyriazis et al #1494

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petrelharp opened this issue Jun 20, 2023 · 4 comments
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add 'best' DFE from Kyriazis et al #1494

petrelharp opened this issue Jun 20, 2023 · 4 comments
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@chriscrsmith

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@petrelharp
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The paper https://www.biorxiv.org/content/10.1101/2022.08.12.503792v1 presents a "best" DFE they recommend using for a variety of other species. This is a DFE estimated from humans. We should put this one in!
@petrelharp petrelharp mentioned this issue Jun 20, 2023
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@petrelharp
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From the meeting: Should this be a "generic" DFE or under HomSap? (ping @ckyriazis?)

@petrelharp
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Note that to do this you'll need to use #1488.

@ckyriazis
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the way we present it in our paper is that it could be used as a "generic DFE" for species that dont have a DFE (since some evidence suggests that the DFE doesnt vary a ton, at least across mammals) but in reality it is pretty much a human DFE estimated from human data. so my vote would be to add it to HomSap

@chriscrsmith chriscrsmith mentioned this issue Aug 5, 2023
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@petrelharp
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This was done in #1505.

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@petrelharp @chriscrsmith @ckyriazis