NDManager is a python package that helps you manage your nuclear data files in a clean manner.
It provides an API and a CLI for creating and interacting with a database of ENDF6 files, as well as processed data files and depletion chain files in the OpenMC format.
In addition, it encapsulate the sandy nuclear data sampling tool to help you easily generate perturbed files in the OpenMC HDF5 format.
Full documentation is available here.