topics Absorption models Sequential Zero-/first-order absorption Parallel zero-/first-order absorption Time-varying KA Transit model with estimated compartment number Infusion Modeling rate and duration Population modeling Mixture models simeta example Inter-occasion variability Simulate from bootstrap parameter estimates Error models Sigma-Like THETA Data sets Input data sets Application Simulating large time-to-event trials Sobol sensitivity analysis - with sensobol package Sobol sensitivity analysis - with sensitivity package Local sensitivity analysis - with mrgsim.sa Graphical sensitivity analysis - with mrgsim.sa Parallel simulation Estimate parameters for two endpoints Adaptive dosing examples Simple adaptive dosing