C++ code for Zhang, Wu et al. Enhanced Ca2+-Driven Arrhythmias in Female Patients with Atrial Fibrillation: Insights from Computational Modeling.

---

Contents:

• ReadMe.md: this file

• sex_diff_model_APclamp: Baseline code

• ```Drug_RyR_restore``: Intervention simulation (RyR Down)

• Drug_flec: Intervention simulation (Flecainide)

• build_population.sh: Script for building population simulation

• run_all.sh: Script for running population simulation

---

Simulation environment:

• Operating system: Linux Mint 20.3 Una
• C++ version: C++11
• C++ compiler: C++ icpc
• Toolkit: Intel® oneAPI Base Toolkit, Intel® HPC Toolkit

---

References:

Xianwei Zhang, Yixuan Wu, Charlotte Smith, William E Louch, Stefano Morotti, Dobromir Dobrev, Eleonora Grandi, Haibo Ni. Enhanced Ca2+-Driven Arrhythmias in Female Patients with Atrial Fibrillation: Insights from Computational Modeling. JACC: Clinical Electrophysiology. https://doi.org/10.1016/j.jacep.2024.07.020

Zhang, Xianwei, Haibo Ni, Stefano Morotti, Charlotte E. R. Smith, Daisuke Sato, William E. Louch, Andrew G. Edwards, and Eleonora Grandi. Mechanisms of Spontaneous Ca2+ Release-Mediated Arrhythmia in a Novel 3D Human Atrial Myocyte Model: I. Transverse-Axial Tubule Variation. The Journal of Physiology. https://doi.org/10.1113/JP283363.

Zhang, Xianwei, Charlotte E. R. Smith, Stefano Morotti, Andrew G. Edwards, Daisuke Sato, William E. Louch, Haibo Ni, and Eleonora Grandi. Mechanisms of Spontaneous Ca2+ Release-Mediated Arrhythmia in a Novel 3D Human Atrial Myocyte Model: II. Ca2+-Handling Protein Variation. The Journal of Physiology. https://doi.org/10.1113/JP283602.

Please cite the above papers when using this model.