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The Grandi et al. model was developed by incorporating the experimentally known atrio-ventricular differences into the Grandi-Pasqualini-Bers human ventricular model. Parameters were also tuned to recapitulate action potential and Ca handling characteristics of chronic atrial fibrillation.
drgrandilab/Grandi-et-al-2011-Human-Atrial-Model
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Matlab code of the Grandi et al. human atrial model. This model was developed by incorporating the experimentally known atrio-ventricular differences into the Grandi-Pasqualini-Bers human ventricular model (also available for download in this website). Parameters were also tuned to recapitulate action potential and Ca handling characteristics of chronic atrial fibrillation. Reference: Grandi E, Pandit SV, Voigt N, Workman AJ, Dobrev D, Jalife J, Bers DM. Human Atrial Action Potential and Ca2+ Model: Sinus Rhythm and Chronic Atrial Fibrillation. Circ Res. 2011 Oct 14;109(9):1055-66. Epub 2011 Sep 15 doi: https://doi.org/10.1161/CIRCRESAHA.111.253955 Please cite the above paper when using this model.
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The Grandi et al. model was developed by incorporating the experimentally known atrio-ventricular differences into the Grandi-Pasqualini-Bers human ventricular model. Parameters were also tuned to recapitulate action potential and Ca handling characteristics of chronic atrial fibrillation.
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