Matlab code of the Morotti et al. model of the sinoatrial node myocyte in mouse updated to investigate the role of the Dnajb6 gene in sick sinus syndrome
The Morotti et al. model (which can be downloaded from this website) was originally developed modifying the Kharche et al. model (Am. J. Physiol. Heart Circ. Physiol. 2011, 301, H945–H963) to reproduce an experimental dataset collected in the Proenza Lab.
Please cite the following papers when using this code:
Morotti S, Ni H, Peters CH, Rickert C, Asgari-Targhi A, Sato D, Glukhov AV, Proenza C, Grandi E. Intracellular Na+ Modulates Pacemaking Activity in Murine Sinoatrial Node Myocytes: An In Silico Analysis. Int J Mol Sci. 2021 May 26;22(11):5645. doi: 10.3390/ijms22115645.
Ding Y, Lang D, Yan J, Bu H, Li H, Jiao K, Yang J, Ni H, Morotti S, Le T, Clark KJ, Port J, Ekker SC, Cao H, Zhang Y, Wang J, Grandi E, Li Z, Shi Y, Li Y, Glukhov AV, Xu X. A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene. Elife. 2022 Oct 18;11:e77327. doi: 10.7554/eLife.77327.
License: MIT License.