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Previously missing PB subtypes added #601

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Aug 16, 2024
Merged

Previously missing PB subtypes added #601

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4caff92
Previously missing PB subtypes added
sangeetashukla Jul 22, 2024
e681630
Removed additional subtypes per comments on OPC PR601
sangeetashukla Aug 6, 2024
638b8f3
fix bug where methyl subtype existed when low conf
jharenza Aug 15, 2024
75aaad6
🧱 Increase size for analysis job
devbyaccident Aug 15, 2024
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25 changes: 23 additions & 2 deletions analyses/molecular-subtyping-PB/01-molecular-subtype-pineoblastoma.Rmd
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Original file line number Diff line number Diff line change
Expand Up @@ -46,7 +46,14 @@ pb_meta <- histo %>%
dkfz_v12_methylation_subclass == "PIN_RB" ~ "PB, RB1",
dkfz_v12_methylation_subclass == "PB_GRP1A" ~ "PB, Group 1A",
dkfz_v12_methylation_subclass == "PB_GRP1B" ~ "PB, Group 1B",
dkfz_v12_methylation_subclass == "PB_GRP2" ~ "PB, Group 2"))
dkfz_v12_methylation_subclass == "PB_GRP2" ~ "PB, Group 2",
dkfz_v12_methylation_subclass == "ETMR_C19MC" ~ "EMTR, C19MC",
dkfz_v12_methylation_subclass == "PTPR_B" ~ "PTPR, Beta",
dkfz_v12_methylation_subclass == "PPTID_A" ~ "PPTID, Alpha",
dkfz_v12_methylation_subclass == "MB_WNT" ~ "MB, WNT",
dkfz_v12_methylation_subclass == "CTRL_PIN" ~ "CTRL, PIN"
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))


```

Expand All @@ -62,14 +69,28 @@ pb_meta <- histo %>%
## PB_GRP2: pineoblastoma, miRNA processing-altered 2 (PB, Group 2)
## PIN_RB: pineoblastoma, RB1-altered (PB, RB1)

## Additional subtypes added on 07/22/2024
## Edited By: Sangeeta Shukla
## ETMR_C19MC: Embryonal tumor with multilayered rosettes (ETMR), C19MC-altered
## PTPR_B: Protein Tyrosine Phosphatase Receptor-Type Beta
## PPTID_A: Ppineal Parenchymal Tumor of Intermediate Differentiation Type A
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## MB_WNT: Medulloblastoma, WNT-activated
## CTRL_PIN: Prostatic Intraepithelial Neoplasia (PIN), Control
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```{r}

pb_methy_with_subtype <- pb_meta %>%
filter(experimental_strategy == "Methylation" & dkfz_v12_methylation_subclass_score >= 0.8) %>%
mutate(molecular_subtype = case_when(molecular_subtype_methyl == "PB, MYC/FOXR2" ~ "PB, MYC/FOXR2",
molecular_subtype_methyl == "PB, RB1" ~ "PB, RB1",
molecular_subtype_methyl %in% c("PB, Group 1A", "PB, Group 1B") ~ "PB, Group 1",
molecular_subtype_methyl == "PB, Group 2" ~ "PB, Group 2"))
molecular_subtype_methyl == "PB, Group 2" ~ "PB, Group 2",
molecular_subtype_methyl == "EMTR, C19MC" ~ "EMTR, C19MC",
molecular_subtype_methyl == "PTPR, Beta" ~ "PTPR, Beta",
molecular_subtype_methyl == "PPTID, Alpha" ~ "PPTID, Alpha",
molecular_subtype_methyl == "MB, WNT" ~ "MB, WNT",
molecular_subtype_methyl == "CTRL, PIN" ~ "CTRL, PIN"))
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pb_methy_without_subtype <- pb_meta %>%
Expand Down
95 changes: 66 additions & 29 deletions analyses/molecular-subtyping-PB/01-molecular-subtype-pineoblastoma.html
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Expand Up @@ -360,13 +360,13 @@ <h4 class="date">2023-12-06</h4>
<div id="load-library" class="section level2">
<h2>load library</h2>
<pre class="r"><code>library(tidyverse)</code></pre>
<pre><code>## ── Attaching core tidyverse packages ─────────────────────────────────────────── tidyverse 2.0.0 ──
## ✔ dplyr 1.1.1 ✔ readr 2.1.4
## ✔ forcats 1.0.0 ✔ stringr 1.5.0
## ✔ ggplot2 3.4.2 ✔ tibble 3.2.1
## ✔ lubridate 1.9.2 ✔ tidyr 1.3.0
## ✔ purrr 1.0.1
## ── Conflicts ───────────────────────────────────────────────────────────── tidyverse_conflicts() ──
<pre><code>## ── Attaching core tidyverse packages ─────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────── tidyverse 2.0.0 ──
## ✔ dplyr 1.1.4 ✔ readr 2.1.5
## ✔ forcats 1.0.0 ✔ stringr 1.5.1
## ✔ ggplot2 3.5.1 ✔ tibble 3.2.1
## ✔ lubridate 1.9.3 ✔ tidyr 1.3.1
## ✔ purrr 1.0.2
## ── Conflicts ───────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────── tidyverse_conflicts() ──
## ✖ dplyr::filter() masks stats::filter()
## ✖ dplyr::lag() masks stats::lag()
## ℹ Use the conflicted package (&lt;http://conflicted.r-lib.org/&gt;) to force all conflicts to become errors</code></pre>
Expand All @@ -385,7 +385,7 @@ <h2>set directories</h2>
<h2>read files</h2>
<pre class="r"><code>histo &lt;- readr::read_tsv(file.path(data_dir, &quot;histologies-base.tsv&quot;))</code></pre>
<pre><code>## Rows: 47895 Columns: 64
## ── Column specification ───────────────────────────────────────────────────────────────────────────
## ── Column specification ───────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────
## Delimiter: &quot;\t&quot;
## chr (41): Kids_First_Participant_ID, Kids_First_Biospecimen_ID, sample_id, a...
## dbl (21): cell_line_passage, OS_days, EFS_days, age_at_diagnosis_days, age_a...
Expand All @@ -409,7 +409,13 @@ <h2>select PB samples from histologies</h2>
dkfz_v12_methylation_subclass == &quot;PIN_RB&quot; ~ &quot;PB, RB1&quot;,
dkfz_v12_methylation_subclass == &quot;PB_GRP1A&quot; ~ &quot;PB, Group 1A&quot;,
dkfz_v12_methylation_subclass == &quot;PB_GRP1B&quot; ~ &quot;PB, Group 1B&quot;,
dkfz_v12_methylation_subclass == &quot;PB_GRP2&quot; ~ &quot;PB, Group 2&quot;)) </code></pre>
dkfz_v12_methylation_subclass == &quot;PB_GRP2&quot; ~ &quot;PB, Group 2&quot;,
dkfz_v12_methylation_subclass == &quot;ETMR_C19MC&quot; ~ &quot;EMTR, C19MC&quot;,
dkfz_v12_methylation_subclass == &quot;PTPR_B&quot; ~ &quot;PTPR, Beta&quot;,
dkfz_v12_methylation_subclass == &quot;PPTID_A&quot; ~ &quot;PPTID, Alpha&quot;,
dkfz_v12_methylation_subclass == &quot;MB_WNT&quot; ~ &quot;MB, WNT&quot;,
dkfz_v12_methylation_subclass == &quot;CTRL_PIN&quot; ~ &quot;CTRL, PIN&quot;
))</code></pre>
</div>
<div id="there-are-four-subtypes" class="section level2">
<h2>there are four subtypes:</h2>
Expand Down Expand Up @@ -442,12 +448,40 @@ <h2>PB_GRP2: pineoblastoma, miRNA processing-altered 2 (PB, Group
</div>
<div id="pin_rb-pineoblastoma-rb1-altered-pb-rb1" class="section level2">
<h2>PIN_RB: pineoblastoma, RB1-altered (PB, RB1)</h2>
</div>
<div id="additional-subtypes-added-on-07222024" class="section level2">
<h2>Additional subtypes added on 07/22/2024</h2>
</div>
<div id="edited-by-sangeeta-shukla" class="section level2">
<h2>Edited By: Sangeeta Shukla</h2>
</div>
<div id="etmr_c19mc-embryonal-tumor-with-multilayered-rosettes-etmr-c19mc-altered" class="section level2">
<h2>ETMR_C19MC: Embryonal tumor with multilayered rosettes (ETMR),
C19MC-altered</h2>
</div>
<div id="ptpr_b-protein-tyrosine-phosphatase-receptor-type-beta" class="section level2">
<h2>PTPR_B: Protein Tyrosine Phosphatase Receptor-Type Beta</h2>
</div>
<div id="pptid_a-ppineal-parenchymal-tumor-of-intermediate-differentiation-type-a" class="section level2">
<h2>PPTID_A: Ppineal Parenchymal Tumor of Intermediate Differentiation
Type A</h2>
</div>
<div id="mb_wnt-medulloblastoma-wnt-activated" class="section level2">
<h2>MB_WNT: Medulloblastoma, WNT-activated</h2>
</div>
<div id="ctrl_pin-prostatic-intraepithelial-neoplasia-pin-control" class="section level2">
<h2>CTRL_PIN: Prostatic Intraepithelial Neoplasia (PIN), Control</h2>
<pre class="r"><code>pb_methy_with_subtype &lt;- pb_meta %&gt;%
filter(experimental_strategy == &quot;Methylation&quot; &amp; dkfz_v12_methylation_subclass_score &gt;= 0.8) %&gt;%
mutate(molecular_subtype = case_when(molecular_subtype_methyl == &quot;PB, MYC/FOXR2&quot; ~ &quot;PB, MYC/FOXR2&quot;,
molecular_subtype_methyl == &quot;PB, RB1&quot; ~ &quot;PB, RB1&quot;,
molecular_subtype_methyl %in% c(&quot;PB, Group 1A&quot;, &quot;PB, Group 1B&quot;) ~ &quot;PB, Group 1&quot;,
molecular_subtype_methyl == &quot;PB, Group 2&quot; ~ &quot;PB, Group 2&quot;))
molecular_subtype_methyl == &quot;PB, Group 2&quot; ~ &quot;PB, Group 2&quot;,
molecular_subtype_methyl == &quot;EMTR, C19MC&quot; ~ &quot;EMTR, C19MC&quot;,
molecular_subtype_methyl == &quot;PTPR, Beta&quot; ~ &quot;PTPR, Beta&quot;,
molecular_subtype_methyl == &quot;PPTID, Alpha&quot; ~ &quot;PPTID, Alpha&quot;,
molecular_subtype_methyl == &quot;MB, WNT&quot; ~ &quot;MB, WNT&quot;,
molecular_subtype_methyl == &quot;CTRL, PIN&quot; ~ &quot;CTRL, PIN&quot;))


pb_methy_without_subtype &lt;- pb_meta %&gt;%
Expand Down Expand Up @@ -478,13 +512,13 @@ <h2>assign the molecular subtypes to all samples based on the
<div id="session-info" class="section level2">
<h2>session info</h2>
<pre class="r"><code>sessionInfo()</code></pre>
<pre><code>## R version 4.2.3 (2023-03-15)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: Ubuntu 22.04.2 LTS
<pre><code>## R version 4.4.0 (2024-04-24)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 22.04.4 LTS
##
## Matrix products: default
## BLAS: /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so
## BLAS: /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.20.so; LAPACK version 3.10.0
##
## locale:
## [1] LC_CTYPE=en_US.UTF-8 LC_NUMERIC=C
Expand All @@ -494,26 +528,29 @@ <h2>session info</h2>
## [9] LC_ADDRESS=C LC_TELEPHONE=C
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C
##
## time zone: Etc/UTC
## tzcode source: system (glibc)
##
## attached base packages:
## [1] stats graphics grDevices utils datasets methods base
##
## other attached packages:
## [1] lubridate_1.9.2 forcats_1.0.0 stringr_1.5.0 dplyr_1.1.1
## [5] purrr_1.0.1 readr_2.1.4 tidyr_1.3.0 tibble_3.2.1
## [9] ggplot2_3.4.2 tidyverse_2.0.0
## [1] lubridate_1.9.3 forcats_1.0.0 stringr_1.5.1 dplyr_1.1.4
## [5] purrr_1.0.2 readr_2.1.5 tidyr_1.3.1 tibble_3.2.1
## [9] ggplot2_3.5.1 tidyverse_2.0.0
##
## loaded via a namespace (and not attached):
## [1] bslib_0.4.2 compiler_4.2.3 pillar_1.9.0 jquerylib_0.1.4
## [5] tools_4.2.3 bit_4.0.5 digest_0.6.31 timechange_0.2.0
## [9] jsonlite_1.8.4 evaluate_0.20 lifecycle_1.0.3 gtable_0.3.3
## [13] pkgconfig_2.0.3 rlang_1.1.0 cli_3.6.1 parallel_4.2.3
## [17] yaml_2.3.7 xfun_0.38 fastmap_1.1.1 withr_2.5.0
## [21] knitr_1.42 generics_0.1.3 vctrs_0.6.2 sass_0.4.5
## [25] hms_1.1.3 bit64_4.0.5 rprojroot_2.0.3 grid_4.2.3
## [29] tidyselect_1.2.0 glue_1.6.2 R6_2.5.1 fansi_1.0.4
## [33] vroom_1.6.1 rmarkdown_2.21 tzdb_0.3.0 magrittr_2.0.3
## [37] scales_1.2.1 htmltools_0.5.5 colorspace_2.1-0 utf8_1.2.3
## [41] stringi_1.7.12 munsell_0.5.0 cachem_1.0.7 crayon_1.5.2</code></pre>
## [1] bit_4.0.5 gtable_0.3.5 jsonlite_1.8.8 crayon_1.5.2
## [5] compiler_4.4.0 tidyselect_1.2.1 parallel_4.4.0 jquerylib_0.1.4
## [9] scales_1.3.0 yaml_2.3.8 fastmap_1.2.0 R6_2.5.1
## [13] generics_0.1.3 knitr_1.46 rprojroot_2.0.4 munsell_0.5.1
## [17] bslib_0.7.0 pillar_1.9.0 tzdb_0.4.0 rlang_1.1.3
## [21] utf8_1.2.4 stringi_1.8.4 cachem_1.1.0 xfun_0.44
## [25] sass_0.4.9 bit64_4.0.5 timechange_0.3.0 cli_3.6.2
## [29] withr_3.0.0 magrittr_2.0.3 digest_0.6.35 grid_4.4.0
## [33] vroom_1.6.5 hms_1.1.3 lifecycle_1.0.4 vctrs_0.6.5
## [37] evaluate_0.23 glue_1.7.0 fansi_1.0.6 colorspace_2.1-0
## [41] rmarkdown_2.27 tools_4.4.0 pkgconfig_2.0.3 htmltools_0.5.8.1</code></pre>
</div>


Expand Down
30 changes: 15 additions & 15 deletions analyses/molecular-subtyping-PB/results/pineo-molecular-subtypes.tsv
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Original file line number Diff line number Diff line change
@@ -1,7 +1,7 @@
Kids_First_Biospecimen_ID Kids_First_Participant_ID match_id sample_id molecular_subtype_methyl molecular_subtype
BS_5AEBR8CK PT_01MZ62KG PT_01MZ62KG_7316-447_Solid Tissue_Progressive 7316-447 NA PB, To be classified
BS_P39SQPTS PT_01MZ62KG PT_01MZ62KG_7316-447_Solid Tissue_Progressive 7316-447 NA PB, To be classified
BS_TE8QFF7T PT_01MZ62KG PT_01MZ62KG_7316-447_Solid Tissue_Progressive 7316-447 NA PB, To be classified
BS_5AEBR8CK PT_01MZ62KG PT_01MZ62KG_7316-447_Solid Tissue_Progressive 7316-447 EMTR, C19MC EMTR, C19MC
BS_P39SQPTS PT_01MZ62KG PT_01MZ62KG_7316-447_Solid Tissue_Progressive 7316-447 EMTR, C19MC EMTR, C19MC
BS_TE8QFF7T PT_01MZ62KG PT_01MZ62KG_7316-447_Solid Tissue_Progressive 7316-447 EMTR, C19MC EMTR, C19MC
BS_N86NB8J0 PT_4MQT24P4 PT_4MQT24P4_7316-6981_Solid Tissue_Initial CNS Tumor 7316-6981 PB, Group 2 PB, Group 2
BS_PYEB0KYG PT_4MQT24P4 PT_4MQT24P4_7316-6981_Solid Tissue_Initial CNS Tumor 7316-6981 PB, Group 2 PB, Group 2
BS_T3ZJ9R2G PT_4MQT24P4 PT_4MQT24P4_7316-6981_Solid Tissue_Initial CNS Tumor 7316-6981 PB, Group 2 PB, Group 2
Expand All @@ -11,22 +11,22 @@ BS_Z8NSK04Z PT_865QGR0X PT_865QGR0X_7316-4440_Solid Tissue_Initial CNS Tumor 731
BS_6NRTJSYK PT_98QMQZY7 PT_98QMQZY7_7316-464_Solid Tissue_Initial CNS Tumor 7316-464 PB, Group 1A PB, Group 1
BS_JC8YV5V9 PT_98QMQZY7 PT_98QMQZY7_7316-464_Solid Tissue_Initial CNS Tumor 7316-464 PB, Group 1A PB, Group 1
BS_PDNXHWQ8 PT_98QMQZY7 PT_98QMQZY7_7316-464_Solid Tissue_Initial CNS Tumor 7316-464 PB, Group 1A PB, Group 1
BS_JK22KD4A PT_98T18T3B PT_98T18T3B_7316-6686_Solid Tissue_Recurrence 7316-6686 NA PB, To be classified
BS_PKBE5QX6 PT_98T18T3B PT_98T18T3B_7316-6686_Solid Tissue_Recurrence 7316-6686 NA PB, To be classified
BS_R9WTTH5P PT_98T18T3B PT_98T18T3B_7316-6686_Solid Tissue_Recurrence 7316-6686 NA PB, To be classified
BS_JK22KD4A PT_98T18T3B PT_98T18T3B_7316-6686_Solid Tissue_Recurrence 7316-6686 CTRL, PIN PB, To be classified
BS_PKBE5QX6 PT_98T18T3B PT_98T18T3B_7316-6686_Solid Tissue_Recurrence 7316-6686 CTRL, PIN PB, To be classified
BS_R9WTTH5P PT_98T18T3B PT_98T18T3B_7316-6686_Solid Tissue_Recurrence 7316-6686 CTRL, PIN PB, To be classified
BS_9N9B9Y1G PT_B4NYKS5V PT_B4NYKS5V_7316-8720_Solid Tissue_Initial CNS Tumor 7316-8720 PB, Group 1B PB, Group 1
BS_9ZJB6NKX PT_B4NYKS5V PT_B4NYKS5V_7316-8720_Solid Tissue_Initial CNS Tumor 7316-8720 PB, Group 1B PB, Group 1
BS_CGHZD6VP PT_B4NYKS5V PT_B4NYKS5V_7316-8720_Solid Tissue_Initial CNS Tumor 7316-8720 PB, Group 1B PB, Group 1
BS_HFC14C3X PT_B4NYKS5V PT_B4NYKS5V_7316-8720_Solid Tissue_Initial CNS Tumor 7316-8720 PB, Group 1B PB, Group 1
BS_THY47V4T PT_B54PH840 PT_B54PH840_7316-2707_Solid Tissue_Initial CNS Tumor 7316-2707 PB, MYC/FOXR2 PB, MYC/FOXR2
BS_WMEHNDSK PT_B54PH840 PT_B54PH840_7316-2707_Solid Tissue_Initial CNS Tumor 7316-2707 PB, MYC/FOXR2 PB, MYC/FOXR2
BS_XJZQA3AP PT_B54PH840 PT_B54PH840_7316-2707_Solid Tissue_Initial CNS Tumor 7316-2707 PB, MYC/FOXR2 PB, MYC/FOXR2
BS_CYEY58NY PT_BDM0M83S PT_BDM0M83S_7316-3072_Solid Tissue_Initial CNS Tumor 7316-3072 NA PB, To be classified
BS_M16CDR44 PT_BDM0M83S PT_BDM0M83S_7316-3072_Solid Tissue_Initial CNS Tumor 7316-3072 NA PB, To be classified
BS_V52DMGQX PT_BDM0M83S PT_BDM0M83S_7316-3072_Solid Tissue_Initial CNS Tumor 7316-3072 NA PB, To be classified
BS_7E838QJP PT_BX4BBRRM PT_BX4BBRRM_7316-5265_Solid Tissue_Initial CNS Tumor 7316-5265 NA PB, To be classified
BS_N7BCF57T PT_BX4BBRRM PT_BX4BBRRM_7316-5265_Solid Tissue_Initial CNS Tumor 7316-5265 NA PB, To be classified
BS_SA7WDK5W PT_BX4BBRRM PT_BX4BBRRM_7316-5265_Solid Tissue_Initial CNS Tumor 7316-5265 NA PB, To be classified
BS_CYEY58NY PT_BDM0M83S PT_BDM0M83S_7316-3072_Solid Tissue_Initial CNS Tumor 7316-3072 MB, WNT MB, WNT
BS_M16CDR44 PT_BDM0M83S PT_BDM0M83S_7316-3072_Solid Tissue_Initial CNS Tumor 7316-3072 MB, WNT MB, WNT
BS_V52DMGQX PT_BDM0M83S PT_BDM0M83S_7316-3072_Solid Tissue_Initial CNS Tumor 7316-3072 MB, WNT MB, WNT
BS_7E838QJP PT_BX4BBRRM PT_BX4BBRRM_7316-5265_Solid Tissue_Initial CNS Tumor 7316-5265 PPTID, Alpha PB, To be classified
BS_N7BCF57T PT_BX4BBRRM PT_BX4BBRRM_7316-5265_Solid Tissue_Initial CNS Tumor 7316-5265 PPTID, Alpha PB, To be classified
BS_SA7WDK5W PT_BX4BBRRM PT_BX4BBRRM_7316-5265_Solid Tissue_Initial CNS Tumor 7316-5265 PPTID, Alpha PB, To be classified
BS_V1B42JPX PT_BX4BBRRM PT_BX4BBRRM_ET_DEX0C8HE_Solid Tissue_Primary Tumor ET_DEX0C8HE NA PB, To be classified
BS_269X6Y6G PT_C41JYFF4 PT_C41JYFF4_7316-5300_Solid Tissue_Initial CNS Tumor 7316-5300 PB, Group 2 PB, Group 2
BS_6B5QA2AK PT_C41JYFF4 PT_C41JYFF4_7316-5300_Solid Tissue_Initial CNS Tumor 7316-5300 PB, Group 2 PB, Group 2
Expand All @@ -48,9 +48,9 @@ BS_2RKFDHEG PT_FED9T9NH PT_FED9T9NH_C4106109-Tumor_Solid Tissue_Recurrence C4106
BS_N3710YR1 PT_FED9T9NH PT_FED9T9NH_C4106109-Tumor_Solid Tissue_Recurrence C4106109-Tumor NA PB, To be classified
BS_AZJ4ED6K PT_G6FP5J9Y PT_G6FP5J9Y_7316-7067_Solid Tissue_Initial CNS Tumor 7316-7067 NA PB, To be classified
BS_C04GDZD9 PT_G6FP5J9Y PT_G6FP5J9Y_7316-7067_Solid Tissue_Initial CNS Tumor 7316-7067 NA PB, To be classified
BS_3NNQ6PSB PT_GNKRMTQY PT_GNKRMTQY_7316-3856_Solid Tissue_Initial CNS Tumor 7316-3856 NA PB, To be classified
BS_H1MNXNHB PT_GNKRMTQY PT_GNKRMTQY_7316-3856_Solid Tissue_Initial CNS Tumor 7316-3856 NA PB, To be classified
BS_MJ6K7TE6 PT_GNKRMTQY PT_GNKRMTQY_7316-3856_Solid Tissue_Initial CNS Tumor 7316-3856 NA PB, To be classified
BS_3NNQ6PSB PT_GNKRMTQY PT_GNKRMTQY_7316-3856_Solid Tissue_Initial CNS Tumor 7316-3856 PTPR, Beta PB, To be classified
BS_H1MNXNHB PT_GNKRMTQY PT_GNKRMTQY_7316-3856_Solid Tissue_Initial CNS Tumor 7316-3856 PTPR, Beta PB, To be classified
BS_MJ6K7TE6 PT_GNKRMTQY PT_GNKRMTQY_7316-3856_Solid Tissue_Initial CNS Tumor 7316-3856 PTPR, Beta PB, To be classified
BS_JXQZ1NJJ PT_NVFBGMWK PT_NVFBGMWK_7316-6984_Solid Tissue_Initial CNS Tumor 7316-6984 PB, Group 1A PB, Group 1
BS_ZQQPDGX4 PT_NVFBGMWK PT_NVFBGMWK_7316-6984_Solid Tissue_Initial CNS Tumor 7316-6984 PB, Group 1A PB, Group 1
BS_1BFJJ3PA PT_P9GVEXFE PT_P9GVEXFE_7316-3322_Solid Tissue_Progressive 7316-3322 PB, MYC/FOXR2 PB, MYC/FOXR2
Expand Down
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