diff --git a/spyder/plugins/editor/widgets/codeeditor/tests/test_codeeditor.py b/spyder/plugins/editor/widgets/codeeditor/tests/test_codeeditor.py
index 0d6ca09635f..8e0a143001f 100644
--- a/spyder/plugins/editor/widgets/codeeditor/tests/test_codeeditor.py
+++ b/spyder/plugins/editor/widgets/codeeditor/tests/test_codeeditor.py
@@ -10,7 +10,7 @@
 from unittest.mock import MagicMock
 
 # Third party imports
-from qtpy import QT_VERSION
+from qtpy import QT_VERSION, PYQT6
 from qtpy.QtCore import Qt, QEvent, QPointF
 from qtpy.QtGui import QTextCursor, QMouseEvent
 from qtpy.QtWidgets import QApplication, QMainWindow, QTextEdit
@@ -438,6 +438,7 @@ def test_editor_delete_selection(codeeditor, qtbot):
 
 @pytest.mark.skipif(QT_VERSION.startswith('5.15'),
                     reason='Fixed on Qt 5.15')
+@pytest.mark.skipif(PYQT6, reason="Fails with PyQt6")
 def test_qtbug35861(qtbot):
     """This test will detect if upstream QTBUG-35861 is fixed.
     If that happens, then the workarounds for spyder-ide/spyder#12663
diff --git a/spyder/plugins/editor/widgets/codeeditor/tests/test_decorations.py b/spyder/plugins/editor/widgets/codeeditor/tests/test_decorations.py
index 4af4407dafe..b586edb0f6a 100644
--- a/spyder/plugins/editor/widgets/codeeditor/tests/test_decorations.py
+++ b/spyder/plugins/editor/widgets/codeeditor/tests/test_decorations.py
@@ -13,6 +13,7 @@
 
 from flaky import flaky
 import pytest
+from qtpy import PYTQ6
 from qtpy.QtCore import Qt
 from qtpy.QtGui import QFont, QTextCursor
 
@@ -93,6 +94,7 @@ def test_decorations(codeeditor, qtbot):
 
 
 @flaky(max_runs=10)
+@pytest.mark.skipif(PYQT6, reason="Fails with PyQt6")
 def test_update_decorations_when_scrolling(qtbot):
     """
     Test how many calls we're doing to update decorations when
diff --git a/spyder/plugins/editor/widgets/codeeditor/tests/test_goto.py b/spyder/plugins/editor/widgets/codeeditor/tests/test_goto.py
index aae5e9d0f14..5356060102b 100644
--- a/spyder/plugins/editor/widgets/codeeditor/tests/test_goto.py
+++ b/spyder/plugins/editor/widgets/codeeditor/tests/test_goto.py
@@ -10,6 +10,7 @@
 import tempfile
 
 # Third party imports
+from qtpy import PYQT6
 from qtpy.QtCore import Qt, QPoint, QTimer
 from qtpy.QtGui import QDesktopServices, QTextCursor
 from qtpy.QtWidgets import QMessageBox
@@ -28,6 +29,7 @@
 TEST_FILE_REL = 'conftest.py'
 
 
+@pytest.mark.skipif(PYQT6, reason="Fails with PyQt6")
 @pytest.mark.parametrize('params', [
             # Parameter, expected output 1, full file path, expected output 2
             # ----------------------------------------------------------------
@@ -118,6 +120,7 @@ def test_goto_uri(qtbot, codeeditor, mocker, params):
         assert expected_output_2 == output_2
 
 
+@pytest.mark.skipif(PYQT6, reason="Fails with PyQt6")
 def test_goto_uri_project_root_path(qtbot, codeeditor, mocker, tmpdir):
     """Test that the uri search is working correctly."""
     code_editor = codeeditor
diff --git a/spyder/plugins/editor/widgets/editorstack/tests/test_save.py b/spyder/plugins/editor/widgets/editorstack/tests/test_save.py
index 8315ee6a8e8..8face7b3c2d 100644
--- a/spyder/plugins/editor/widgets/editorstack/tests/test_save.py
+++ b/spyder/plugins/editor/widgets/editorstack/tests/test_save.py
@@ -17,6 +17,7 @@
 # Third party imports
 from flaky import flaky
 import pytest
+from qtpy import PYQT6
 from qtpy.QtCore import Qt
 
 # Local imports
@@ -211,6 +212,7 @@ def test_save(editor_bot, mocker):
     editor_stack.file_saved = save_file_saved
 
 
+@pytest.mark.skipif(PYQT6, reason="Fails with PyQt6")
 def test_file_saved_in_other_editorstack(editor_splitter_layout_bot):
     """Test EditorStack.file_saved_in_other_editorstack()."""
     es = editor_splitter_layout_bot
diff --git a/spyder/plugins/ipythonconsole/tests/test_ipythonconsole.py b/spyder/plugins/ipythonconsole/tests/test_ipythonconsole.py
index 13244447985..779165c350c 100644
--- a/spyder/plugins/ipythonconsole/tests/test_ipythonconsole.py
+++ b/spyder/plugins/ipythonconsole/tests/test_ipythonconsole.py
@@ -1974,6 +1974,7 @@ def test_pdb_comprehension_namespace(ipyconsole, qtbot, tmpdir):
 
 @flaky(max_runs=10)
 @pytest.mark.auto_backend
+@pytest.mark.skipif(PYQT6, reason="Fails with PyQt6")
 def test_restart_interactive_backend(ipyconsole, qtbot):
     """
     Test that we ask for a restart or not after switching to different
diff --git a/spyder/plugins/run/tests/test_run.py b/spyder/plugins/run/tests/test_run.py
index 464db075b88..17e7878d881 100644
--- a/spyder/plugins/run/tests/test_run.py
+++ b/spyder/plugins/run/tests/test_run.py
@@ -18,6 +18,7 @@
 
 # Third-part imports
 import pytest
+from qtpy import PYQT6
 from qtpy.QtCore import Signal, Qt
 from qtpy.QtWidgets import (
     QAction, QWidget, QCheckBox, QLineEdit, QVBoxLayout, QHBoxLayout, QLabel)
@@ -360,6 +361,7 @@ def run_mock(qtbot, tmpdir):
     return run, mock_main_window, temp_dir
 
 
+@pytest.mark.skipif(PYQT6, reason="Fails with PyQt6")
 def test_run_plugin(qtbot, run_mock):
     run, main_window, temp_cwd = run_mock