diff --git a/python/cuml/cuml/internals/array.py b/python/cuml/cuml/internals/array.py
index 71918f77f5..8e07b5f89a 100644
--- a/python/cuml/cuml/internals/array.py
+++ b/python/cuml/cuml/internals/array.py
@@ -1,5 +1,5 @@
 #
-# Copyright (c) 2020-2024, NVIDIA CORPORATION.
+# Copyright (c) 2020-2025, NVIDIA CORPORATION.
 #
 # Licensed under the Apache License, Version 2.0 (the "License");
 # you may not use this file except in compliance with the License.
@@ -1082,7 +1082,7 @@ def from_input(
                     index = CudfIndex(index)
 
         if isinstance(X, CudfSeries):
-            if X.null_count != 0:
+            if X.null_count != 0 or bool(X.isnull().any()):
                 raise ValueError(
                     "Error: cuDF Series has missing/null values, "
                     "which are not supported by cuML."