diff --git a/lib/web/fetch/body.js b/lib/web/fetch/body.js
index b092b3c83db..80ef027b800 100644
--- a/lib/web/fetch/body.js
+++ b/lib/web/fetch/body.js
@@ -109,7 +109,7 @@ function extractBody (object, keepalive = false) {
 
     // Set source to a copy of the bytes held by object.
     source = new Uint8Array(object.buffer.slice(object.byteOffset, object.byteOffset + object.byteLength))
-  } else if (webidl.is.FormData(object)) {
+  } else if (webidl.is.FormData(object) || (globalThis.FormData && object instanceof FormData)) {
     const boundary = `----formdata-undici-0${`${Math.floor(Math.random() * 1e11)}`.padStart(11, '0')}`
     const prefix = `--${boundary}\r\nContent-Disposition: form-data`
 
diff --git a/lib/web/fetch/formdata.js b/lib/web/fetch/formdata.js
index 8020a26e116..0f7bb766602 100644
--- a/lib/web/fetch/formdata.js
+++ b/lib/web/fetch/formdata.js
@@ -258,6 +258,13 @@ function makeEntry (name, value, filename) {
   return { name, value }
 }
 
-webidl.is.FormData = webidl.util.MakeTypeAssertion(FormData)
+const _isFormData = webidl.util.MakeTypeAssertion(FormData)
+webidl.is.FormData = function (V) {
+  // This is a compatibility fix to support the FormData instance that is shipped in Node.js
+  if (globalThis.FormData && V instanceof globalThis.FormData) {
+    return true
+  }
+  return _isFormData(V)
+}
 
 module.exports = { FormData, makeEntry, setFormDataState }
diff --git a/test/fetch/client-fetch.js b/test/fetch/client-fetch.js
index 3003021390b..af263c2eedf 100644
--- a/test/fetch/client-fetch.js
+++ b/test/fetch/client-fetch.js
@@ -709,3 +709,25 @@ test('Receiving non-Latin1 headers', async (t) => {
   assert.deepStrictEqual(cdHeaders, ContentDisposition)
   assert.deepStrictEqual(lengths, [30, 34, 94, 104, 90])
 })
+
+test('post globalThis.FormData with Blob', (t, done) => {
+  const { ok } = tspl(t, { plan: 1 })
+
+  // We use the FormData that is shipped in Node.js
+  const body = new globalThis.FormData()
+  body.append('field1', new Blob(['asd1']))
+
+  const server = createServer((req, res) => {
+    req.pipe(res)
+  })
+  t.after(closeServerAsPromise(server))
+
+  server.listen(0, async () => {
+    const res = await fetch(`http://localhost:${server.address().port}`, {
+      method: 'PUT',
+      body
+    })
+    ok(/asd1/.test(await res.text()))
+    done()
+  })
+})