From 5298b32edd02c212ea929172b87af918967e143d Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 11:45:39 -0500 Subject: [PATCH 001/176] CNAME archive --- CNAME => archive_CNAME | 0 1 file changed, 0 insertions(+), 0 deletions(-) rename CNAME => archive_CNAME (100%) diff --git a/CNAME b/archive_CNAME similarity index 100% rename from CNAME rename to archive_CNAME From 9dcccafadef0f4a0feccf611b28ceca428a688b9 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 11:49:06 -0500 Subject: [PATCH 002/176] adding jen-dfci url to retype.yml --- retype.yml | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/retype.yml b/retype.yml index 00f2ad5b..cbc8b234 100644 --- a/retype.yml +++ b/retype.yml @@ -1,6 +1,6 @@ input: . output: .retype -url: # Add your website address here +url: https://jen-dfci.github.io/htan_manual/ branding: title: HTAN label: Manual From f5471a90cd7e2bc2113de77fca5db90f912ff521 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 12:05:24 -0500 Subject: [PATCH 003/176] removing https from retype.yml url --- retype.yml | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/retype.yml b/retype.yml index cbc8b234..a0111254 100644 --- a/retype.yml +++ b/retype.yml @@ -1,6 +1,6 @@ input: . output: .retype -url: https://jen-dfci.github.io/htan_manual/ +url: jen-dfci.github.io/htan_manual/ branding: title: HTAN label: Manual From a0c89bf745dff550d7f2b4fc51e24bc08fda1b58 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 12:07:07 -0500 Subject: [PATCH 004/176] chg url in retype.yml to htan_missing_manual --- retype.yml | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/retype.yml b/retype.yml index a0111254..ef9b0059 100644 --- a/retype.yml +++ b/retype.yml @@ -1,6 +1,6 @@ input: . output: .retype -url: jen-dfci.github.io/htan_manual/ +url: jen-dfci.github.io/htan_missing_manual/ branding: title: HTAN label: Manual From 98d19e33ea9d49e84a1cef1c475bf3f83836cfa1 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 13:45:18 -0500 Subject: [PATCH 005/176] Adding additional folders --- addtnl_info/index.yml | 2 ++ data_pub_submission/index.yml | 2 ++ tool_protocol_submission/index.yml | 2 ++ 3 files changed, 6 insertions(+) create mode 100644 addtnl_info/index.yml create mode 100644 data_pub_submission/index.yml create mode 100644 tool_protocol_submission/index.yml diff --git a/addtnl_info/index.yml b/addtnl_info/index.yml new file mode 100644 index 00000000..187f0a42 --- /dev/null +++ b/addtnl_info/index.yml @@ -0,0 +1,2 @@ +label: Additional Information +order: 994 diff --git a/data_pub_submission/index.yml b/data_pub_submission/index.yml new file mode 100644 index 00000000..e001e21b --- /dev/null +++ b/data_pub_submission/index.yml @@ -0,0 +1,2 @@ +label: Data and Publication Submissions +order: 996 diff --git a/tool_protocol_submission/index.yml b/tool_protocol_submission/index.yml new file mode 100644 index 00000000..e6f37677 --- /dev/null +++ b/tool_protocol_submission/index.yml @@ -0,0 +1,2 @@ +label: Tool and Protocol Submissions +order: 995 From cda385277261b19f23f6d33dde872807697645aa Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 13:50:26 -0500 Subject: [PATCH 006/176] adding overview.md to data_pub_submission. --- data_pub_submission/overview.md | 8 ++++++++ 1 file changed, 8 insertions(+) create mode 100644 data_pub_submission/overview.md diff --git a/data_pub_submission/overview.md b/data_pub_submission/overview.md new file mode 100644 index 00000000..6fcecbc6 --- /dev/null +++ b/data_pub_submission/overview.md @@ -0,0 +1,8 @@ +--- +order: 1000 +--- + +# Data and Publication Submissions Overview +Only HTAN Centers and Associate Members can submit data to the HTAN Network's repositories. The Data Submission Section of the Manual is intended as a guide for HTAN Centers and Associate Members. + + From 5049c680f89dc6b39013f55a4dcfcc9a573ab80f Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 14:07:09 -0500 Subject: [PATCH 007/176] updated to data_pub_submission folder. --- data_pub_submission/Data_Deidentification.md | 5 +++++ data_pub_submission/Data_Liaisons.md | 5 +++++ data_pub_submission/Information_New_Centers.md | 17 +++++++++++++++++ data_pub_submission/overview.md | 4 +++- 4 files changed, 30 insertions(+), 1 deletion(-) create mode 100644 data_pub_submission/Data_Deidentification.md create mode 100644 data_pub_submission/Data_Liaisons.md create mode 100644 data_pub_submission/Information_New_Centers.md diff --git a/data_pub_submission/Data_Deidentification.md b/data_pub_submission/Data_Deidentification.md new file mode 100644 index 00000000..b74878d0 --- /dev/null +++ b/data_pub_submission/Data_Deidentification.md @@ -0,0 +1,5 @@ +--- +order: 998 +--- + +# Data De-Identification diff --git a/data_pub_submission/Data_Liaisons.md b/data_pub_submission/Data_Liaisons.md new file mode 100644 index 00000000..9815e6d9 --- /dev/null +++ b/data_pub_submission/Data_Liaisons.md @@ -0,0 +1,5 @@ +--- +order: 997 +--- + +# Data Liaisons diff --git a/data_pub_submission/Information_New_Centers.md b/data_pub_submission/Information_New_Centers.md new file mode 100644 index 00000000..add01e08 --- /dev/null +++ b/data_pub_submission/Information_New_Centers.md @@ -0,0 +1,17 @@ +--- +order: 999 +--- + +# Information for New HTAN Centers + +Welcome to the HTAN Network! + +Documents provided on the HTAN [resources page](https://humantumoratlas.org/resources) will help you understand requirements for publications, data sharing and data use. + +All HTAN members must have an executed Human Tumor Atlas Network DMSA (Internal Data and Materials Sharing Agreement) (HTAN DMSA) (https://docs.google.com/document/d/1RPFm9MBJv8DjZmYZyIv0jbjtNJ8fnwGjYDjlK4lL4nc/edit) with Sage Bionetworks prior to contributing or accessing data in the HTAN DCC. To initiate execution of the HTAN DMSA, contact Sage HTAN Governance (htan@sagebionetworks.jira.com). Please include the name and contact information of your HTAN PI and Institution Signatory to enable routing the HTAN DMSA for execution. + +HTAN Centers are assigned a [data liaison](../data_liaison.md) from the HTAN Data Coordinating Center (DCC)](https://humantumoratlas.org/htan-dcc)). Trans-Network Projects (TNPs) are also assigned liaisons. Your liaison will help guide you through setting up a new atlas or project, creating HTAN identifiers, filling out metadata sheets, and submitting data. Please keep your liaison informed of publications timelines and new data submissions. + +Please see the appropriate page of this manual for additional details about HTAN center responsibilities for data de-identification and instructions regarding how to submit data. Clinical, biospecimen, and assay data submitted to the DCC are distributed to repositories based on access levels. Information regarding how data are accessed by external users is described more in [other parts of this manual](https://docs.humantumoratlas.org/overview/data_access_levels/). + +In order to support the FAIR (Findability, Accessibility, Interoperability, and Reusability) principles for scientific data production, the DCC has developed a [data model](https://humantumoratlas.org/standards) based on established standards in the scientific research community. The HTAN Data Model is expected to evolve with advances in science. This evolution is a community-driven, peer-reviewed process, where members of a working group will first assess established community data standards and create a request for comment (RFC) document soliciting community feedback. Adding new data types and the RFC process are described in more detail in later pages of this manual. We look forward to working with you and learning from your expertise as we improve upon our current model. diff --git a/data_pub_submission/overview.md b/data_pub_submission/overview.md index 6fcecbc6..49b5184a 100644 --- a/data_pub_submission/overview.md +++ b/data_pub_submission/overview.md @@ -2,7 +2,9 @@ order: 1000 --- -# Data and Publication Submissions Overview +# Data and Publication Submission Overview Only HTAN Centers and Associate Members can submit data to the HTAN Network's repositories. The Data Submission Section of the Manual is intended as a guide for HTAN Centers and Associate Members. + + From c803ccf2d9cc784a87e13c75d664efbf9be2ca5a Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 14:10:03 -0500 Subject: [PATCH 008/176] updates to data_pub_submission folder. --- data_pub_submission/Information_New_Centers.md | 4 ++-- data_pub_submission/overview.md | 2 +- 2 files changed, 3 insertions(+), 3 deletions(-) diff --git a/data_pub_submission/Information_New_Centers.md b/data_pub_submission/Information_New_Centers.md index add01e08..fd2ee901 100644 --- a/data_pub_submission/Information_New_Centers.md +++ b/data_pub_submission/Information_New_Centers.md @@ -8,9 +8,9 @@ Welcome to the HTAN Network! Documents provided on the HTAN [resources page](https://humantumoratlas.org/resources) will help you understand requirements for publications, data sharing and data use. -All HTAN members must have an executed Human Tumor Atlas Network DMSA (Internal Data and Materials Sharing Agreement) (HTAN DMSA) (https://docs.google.com/document/d/1RPFm9MBJv8DjZmYZyIv0jbjtNJ8fnwGjYDjlK4lL4nc/edit) with Sage Bionetworks prior to contributing or accessing data in the HTAN DCC. To initiate execution of the HTAN DMSA, contact Sage HTAN Governance (htan@sagebionetworks.jira.com). Please include the name and contact information of your HTAN PI and Institution Signatory to enable routing the HTAN DMSA for execution. +All HTAN members must have an executed Human Tumor Atlas Network DMSA (Internal Data and Materials Sharing Agreement) [(HTAN DMSA)](https://docs.google.com/document/d/1RPFm9MBJv8DjZmYZyIv0jbjtNJ8fnwGjYDjlK4lL4nc/edit) with Sage Bionetworks prior to contributing or accessing data in the HTAN DCC. To initiate execution of the HTAN DMSA, contact Sage HTAN Governance (htan@sagebionetworks.jira.com). Please include the name and contact information of your HTAN PI and Institution Signatory to enable routing the HTAN DMSA for execution. -HTAN Centers are assigned a [data liaison](../data_liaison.md) from the HTAN Data Coordinating Center (DCC)](https://humantumoratlas.org/htan-dcc)). Trans-Network Projects (TNPs) are also assigned liaisons. Your liaison will help guide you through setting up a new atlas or project, creating HTAN identifiers, filling out metadata sheets, and submitting data. Please keep your liaison informed of publications timelines and new data submissions. +HTAN Centers are assigned a [data liaison](../data_liaison.md) from the HTAN Data Coordinating Center [(DCC)](https://humantumoratlas.org/htan-dcc). Trans-Network Projects (TNPs) are also assigned liaisons. Your liaison will help guide you through setting up a new atlas or project, creating HTAN identifiers, filling out metadata sheets, and submitting data. Please keep your liaison informed of publications timelines and new data submissions. Please see the appropriate page of this manual for additional details about HTAN center responsibilities for data de-identification and instructions regarding how to submit data. Clinical, biospecimen, and assay data submitted to the DCC are distributed to repositories based on access levels. Information regarding how data are accessed by external users is described more in [other parts of this manual](https://docs.humantumoratlas.org/overview/data_access_levels/). diff --git a/data_pub_submission/overview.md b/data_pub_submission/overview.md index 49b5184a..0d4545ae 100644 --- a/data_pub_submission/overview.md +++ b/data_pub_submission/overview.md @@ -3,7 +3,7 @@ order: 1000 --- # Data and Publication Submission Overview -Only HTAN Centers and Associate Members can submit data to the HTAN Network's repositories. The Data Submission Section of the Manual is intended as a guide for HTAN Centers and Associate Members. +Only HTAN Centers and Associate Members can submit data to the HTAN Network's repositories. The Data Submission Section of this Manual is intended as a guide for HTAN Centers and Associate Members. From 8c13d575643da59f1bc2a1f9ab046313deeafc9e Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 14:11:01 -0500 Subject: [PATCH 009/176] updates to data_pub_submission folder. --- data_pub_submission/Information_New_Centers.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data_pub_submission/Information_New_Centers.md b/data_pub_submission/Information_New_Centers.md index fd2ee901..85cc1a39 100644 --- a/data_pub_submission/Information_New_Centers.md +++ b/data_pub_submission/Information_New_Centers.md @@ -10,7 +10,7 @@ Documents provided on the HTAN [resources page](https://humantumoratlas.org/reso All HTAN members must have an executed Human Tumor Atlas Network DMSA (Internal Data and Materials Sharing Agreement) [(HTAN DMSA)](https://docs.google.com/document/d/1RPFm9MBJv8DjZmYZyIv0jbjtNJ8fnwGjYDjlK4lL4nc/edit) with Sage Bionetworks prior to contributing or accessing data in the HTAN DCC. To initiate execution of the HTAN DMSA, contact Sage HTAN Governance (htan@sagebionetworks.jira.com). Please include the name and contact information of your HTAN PI and Institution Signatory to enable routing the HTAN DMSA for execution. -HTAN Centers are assigned a [data liaison](../data_liaison.md) from the HTAN Data Coordinating Center [(DCC)](https://humantumoratlas.org/htan-dcc). Trans-Network Projects (TNPs) are also assigned liaisons. Your liaison will help guide you through setting up a new atlas or project, creating HTAN identifiers, filling out metadata sheets, and submitting data. Please keep your liaison informed of publications timelines and new data submissions. +HTAN Centers are assigned a [data liaison](../Data_Liaisons.md) from the HTAN Data Coordinating Center [(DCC)](https://humantumoratlas.org/htan-dcc). Trans-Network Projects (TNPs) are also assigned liaisons. Your liaison will help guide you through setting up a new atlas or project, creating HTAN identifiers, filling out metadata sheets, and submitting data. Please keep your liaison informed of publications timelines and new data submissions. Please see the appropriate page of this manual for additional details about HTAN center responsibilities for data de-identification and instructions regarding how to submit data. Clinical, biospecimen, and assay data submitted to the DCC are distributed to repositories based on access levels. Information regarding how data are accessed by external users is described more in [other parts of this manual](https://docs.humantumoratlas.org/overview/data_access_levels/). From 508d259f94320b8947e177e87754d3873577c994 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 14:11:35 -0500 Subject: [PATCH 010/176] updates to data_pub_submission folder. --- data_pub_submission/Information_New_Centers.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data_pub_submission/Information_New_Centers.md b/data_pub_submission/Information_New_Centers.md index 85cc1a39..29d5b402 100644 --- a/data_pub_submission/Information_New_Centers.md +++ b/data_pub_submission/Information_New_Centers.md @@ -10,7 +10,7 @@ Documents provided on the HTAN [resources page](https://humantumoratlas.org/reso All HTAN members must have an executed Human Tumor Atlas Network DMSA (Internal Data and Materials Sharing Agreement) [(HTAN DMSA)](https://docs.google.com/document/d/1RPFm9MBJv8DjZmYZyIv0jbjtNJ8fnwGjYDjlK4lL4nc/edit) with Sage Bionetworks prior to contributing or accessing data in the HTAN DCC. To initiate execution of the HTAN DMSA, contact Sage HTAN Governance (htan@sagebionetworks.jira.com). Please include the name and contact information of your HTAN PI and Institution Signatory to enable routing the HTAN DMSA for execution. -HTAN Centers are assigned a [data liaison](../Data_Liaisons.md) from the HTAN Data Coordinating Center [(DCC)](https://humantumoratlas.org/htan-dcc). Trans-Network Projects (TNPs) are also assigned liaisons. Your liaison will help guide you through setting up a new atlas or project, creating HTAN identifiers, filling out metadata sheets, and submitting data. Please keep your liaison informed of publications timelines and new data submissions. +HTAN Centers are assigned a [data liaison](../data_pub_submission/Data_Liaisons.md) from the HTAN Data Coordinating Center [(DCC)](https://humantumoratlas.org/htan-dcc). Trans-Network Projects (TNPs) are also assigned liaisons. Your liaison will help guide you through setting up a new atlas or project, creating HTAN identifiers, filling out metadata sheets, and submitting data. Please keep your liaison informed of publications timelines and new data submissions. Please see the appropriate page of this manual for additional details about HTAN center responsibilities for data de-identification and instructions regarding how to submit data. Clinical, biospecimen, and assay data submitted to the DCC are distributed to repositories based on access levels. Information regarding how data are accessed by external users is described more in [other parts of this manual](https://docs.humantumoratlas.org/overview/data_access_levels/). From 295701aa8a39eb01647eafe8b4aa95905014a31a Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 14:13:36 -0500 Subject: [PATCH 011/176] updates to data_pub_submission folder. --- data_pub_submission/Information_New_Centers.md | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/data_pub_submission/Information_New_Centers.md b/data_pub_submission/Information_New_Centers.md index 29d5b402..9f6acddd 100644 --- a/data_pub_submission/Information_New_Centers.md +++ b/data_pub_submission/Information_New_Centers.md @@ -12,6 +12,6 @@ All HTAN members must have an executed Human Tumor Atlas Network DMSA (Internal HTAN Centers are assigned a [data liaison](../data_pub_submission/Data_Liaisons.md) from the HTAN Data Coordinating Center [(DCC)](https://humantumoratlas.org/htan-dcc). Trans-Network Projects (TNPs) are also assigned liaisons. Your liaison will help guide you through setting up a new atlas or project, creating HTAN identifiers, filling out metadata sheets, and submitting data. Please keep your liaison informed of publications timelines and new data submissions. -Please see the appropriate page of this manual for additional details about HTAN center responsibilities for data de-identification and instructions regarding how to submit data. Clinical, biospecimen, and assay data submitted to the DCC are distributed to repositories based on access levels. Information regarding how data are accessed by external users is described more in [other parts of this manual](https://docs.humantumoratlas.org/overview/data_access_levels/). +Please see the appropriate page of this manual for additional details about HTAN center responsibilities for data de-identification and instructions regarding how to submit data. Clinical, biospecimen, and assay data submitted to the DCC are distributed to repositories based on access levels. Information regarding how data are accessed by external users is described more in [other parts of this manual](../overview/data_access_levels.md). -In order to support the FAIR (Findability, Accessibility, Interoperability, and Reusability) principles for scientific data production, the DCC has developed a [data model](https://humantumoratlas.org/standards) based on established standards in the scientific research community. The HTAN Data Model is expected to evolve with advances in science. This evolution is a community-driven, peer-reviewed process, where members of a working group will first assess established community data standards and create a request for comment (RFC) document soliciting community feedback. Adding new data types and the RFC process are described in more detail in later pages of this manual. We look forward to working with you and learning from your expertise as we improve upon our current model. +In order to support the FAIR (Findability, Accessibility, Interoperability, and Reusability) principles for scientific data production, the DCC has developed a [data model](../data_model/) based on established standards in the scientific research community. The HTAN Data Model is expected to evolve with advances in science. This evolution is a community-driven, peer-reviewed process, where members of a working group will first assess established community data standards and create a request for comment (RFC) document soliciting community feedback. Adding new data types and the RFC process are described in more detail in later pages of this manual. We look forward to working with you and learning from your expertise as we improve upon our current model. From 4cba07ebc5dc204d49cc00b6ec21efad242f05d6 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 14:15:13 -0500 Subject: [PATCH 012/176] change data levels to data access levels. --- overview/data_levels.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/overview/data_levels.md b/overview/data_levels.md index 526f2fa3..df8deee3 100644 --- a/overview/data_levels.md +++ b/overview/data_levels.md @@ -2,7 +2,7 @@ order: 998 --- -# HTAN Data Levels +# HTAN Data Access Levels HTAN data is categorized into **two data access levels**: From 8e5a99b95ca97eda9796d4ff8351bf733216d60a Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 14:15:53 -0500 Subject: [PATCH 013/176] . --- data_pub_submission/Information_New_Centers.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data_pub_submission/Information_New_Centers.md b/data_pub_submission/Information_New_Centers.md index 9f6acddd..e146fc3a 100644 --- a/data_pub_submission/Information_New_Centers.md +++ b/data_pub_submission/Information_New_Centers.md @@ -12,6 +12,6 @@ All HTAN members must have an executed Human Tumor Atlas Network DMSA (Internal HTAN Centers are assigned a [data liaison](../data_pub_submission/Data_Liaisons.md) from the HTAN Data Coordinating Center [(DCC)](https://humantumoratlas.org/htan-dcc). Trans-Network Projects (TNPs) are also assigned liaisons. Your liaison will help guide you through setting up a new atlas or project, creating HTAN identifiers, filling out metadata sheets, and submitting data. Please keep your liaison informed of publications timelines and new data submissions. -Please see the appropriate page of this manual for additional details about HTAN center responsibilities for data de-identification and instructions regarding how to submit data. Clinical, biospecimen, and assay data submitted to the DCC are distributed to repositories based on access levels. Information regarding how data are accessed by external users is described more in [other parts of this manual](../overview/data_access_levels.md). +Please see the appropriate page of this manual for additional details about HTAN center responsibilities for data de-identification and instructions regarding how to submit data. Clinical, biospecimen, and assay data submitted to the DCC are distributed to repositories based on access levels. Information regarding how data are accessed by external users is described more in [other parts of this manual](../overview/data_levels.md). In order to support the FAIR (Findability, Accessibility, Interoperability, and Reusability) principles for scientific data production, the DCC has developed a [data model](../data_model/) based on established standards in the scientific research community. The HTAN Data Model is expected to evolve with advances in science. This evolution is a community-driven, peer-reviewed process, where members of a working group will first assess established community data standards and create a request for comment (RFC) document soliciting community feedback. Adding new data types and the RFC process are described in more detail in later pages of this manual. We look forward to working with you and learning from your expertise as we improve upon our current model. From 60e7bce8aaf3ebc60c932fcaaa2cedddd915e19c Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 14:24:21 -0500 Subject: [PATCH 014/176] data liaisons table --- data_pub_submission/Data_Liaisons.md | 26 +++++++++++++++++++ .../Information_New_Centers.md | 2 +- 2 files changed, 27 insertions(+), 1 deletion(-) diff --git a/data_pub_submission/Data_Liaisons.md b/data_pub_submission/Data_Liaisons.md index 9815e6d9..d8bf9a34 100644 --- a/data_pub_submission/Data_Liaisons.md +++ b/data_pub_submission/Data_Liaisons.md @@ -3,3 +3,29 @@ order: 997 --- # Data Liaisons + +Upon joining HTAN, Centers are assigned a data liaison from the DCC; Trans-Network Projects (TNPs) are also assigned liaisons. The DCC liaisons assist each of the research centers in successfully uploading data and metadata files. + +Here is the current list of centers, their atlases and DCC liaisons: + +| Atlas | Atlas ID | Liaison | Email | +|-------|----------|---------|-------| +| PILOT - HTAPP | HTA1 | Vesteinn Thorsson | thorsson@isbscience.org | +| PILOT - PCAPP | HTA2 | Ethan Cerami | cerami@ds.dfci.harvard.edu | +| HTAN BU | HTA3 | Jennifer Altreuter | jennifer@ds.dfci.harvard.edu | +| HTAN CHOP | HTA4 | Ino de Bruijn | ebruiji@mskcc.org | +| HTAN DFCI | HTA5 | Jennifer Altreuter | jennifer@ds.dfci.harvard.edu | +| HTAN Duke | HTA6 | Ino de Bruijn | ebruiji@mskcc.org | +| HTAN HMS | HTA7 | Adam Taylor | adam.taylor@sagebase.org | +| HTAN MSK | HTA8 | Ino de Bruijn | ebruiji@mskcc.org | +| HTAN OHSU | HTA9 | Adam Taylor | adam.taylor@sagebase.org | +| HTAN Stanford | HTA10 | Adam Taylor | adam.taylor@sagebase.org | +| HTAN Vanderbilt | HTA11 | Vesteinn Thorsson | thorsson@isbscience.org | +| HTAN WUSTL | HTA12 | Vesteinn Thorsson | thorsson@isbscience.org | +| TNP SARDANA | HTA13 | Dave Gibbs | dgibbs@systemsbiology.org | +| TNP TMA | HTA14 | Dave Gibbs | dgibbs@systemsbiology.org | +| TNP SRRS | HTA15 | Jennifer Altreuter | jennifer@ds.dfci.harvard.edu | +| TNP CASI | HTA16 | Jennifer Altreuter | jennifer@ds.dfci.harvard.edu | + + + diff --git a/data_pub_submission/Information_New_Centers.md b/data_pub_submission/Information_New_Centers.md index e146fc3a..c90fd077 100644 --- a/data_pub_submission/Information_New_Centers.md +++ b/data_pub_submission/Information_New_Centers.md @@ -12,6 +12,6 @@ All HTAN members must have an executed Human Tumor Atlas Network DMSA (Internal HTAN Centers are assigned a [data liaison](../data_pub_submission/Data_Liaisons.md) from the HTAN Data Coordinating Center [(DCC)](https://humantumoratlas.org/htan-dcc). Trans-Network Projects (TNPs) are also assigned liaisons. Your liaison will help guide you through setting up a new atlas or project, creating HTAN identifiers, filling out metadata sheets, and submitting data. Please keep your liaison informed of publications timelines and new data submissions. -Please see the appropriate page of this manual for additional details about HTAN center responsibilities for data de-identification and instructions regarding how to submit data. Clinical, biospecimen, and assay data submitted to the DCC are distributed to repositories based on access levels. Information regarding how data are accessed by external users is described more in [other parts of this manual](../overview/data_levels.md). +Please see the appropriate page of this manual for additional details about HTAN center responsibilities for data de-identification and specific instructions regarding how to submit data. Clinical, biospecimen, and assay data submitted to the DCC are distributed to repositories based on access levels. Information regarding how data are accessed by external users is described more in [other parts of this manual](../overview/data_levels.md). In order to support the FAIR (Findability, Accessibility, Interoperability, and Reusability) principles for scientific data production, the DCC has developed a [data model](../data_model/) based on established standards in the scientific research community. The HTAN Data Model is expected to evolve with advances in science. This evolution is a community-driven, peer-reviewed process, where members of a working group will first assess established community data standards and create a request for comment (RFC) document soliciting community feedback. Adding new data types and the RFC process are described in more detail in later pages of this manual. We look forward to working with you and learning from your expertise as we improve upon our current model. From 774555f6e9cc9d17d67b2c8d99b3ab55b81bc1cd Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 14:30:16 -0500 Subject: [PATCH 015/176] data de-id section information added. --- data_pub_submission/Data_Deidentification.md | 12 +++++++++++- data_pub_submission/Data_Liaisons.md | 2 +- 2 files changed, 12 insertions(+), 2 deletions(-) diff --git a/data_pub_submission/Data_Deidentification.md b/data_pub_submission/Data_Deidentification.md index b74878d0..e1878d91 100644 --- a/data_pub_submission/Data_Deidentification.md +++ b/data_pub_submission/Data_Deidentification.md @@ -2,4 +2,14 @@ order: 998 --- -# Data De-Identification +# Data Deidentification + +** HTAN Centers are responsible for data deidentification. ** + +As outlined in the HTAN [DMSA](https://docs.google.com/document/d/1RPFm9MBJv8DjZmYZyIv0jbjtNJ8fnwGjYDjlK4lL4nc/edit#heading=h.gjdgxs), data submitted to the Data Coordinating Center (DCC) must be fully de-identified. + +By signing this DMSA, HTAN members’ institutional signing officials and PIs accept responsibility for the deidentification of data prior to transfer to the DCC and confirm that: (a) all data disclosed to the DCC (Synapse) are fully de-identified in accordance with HIPAA, (b) all data were collected in accordance with protocols approved by an IRB or its equivalent, (c) all data are consistent with applicable U.S. laws, regulations, and its institutional policies and (d) that an IRB/Privacy Board or equivalent body has assured that submission and subsequent sharing of data are consistent with the Informed Consent of the Data Subject(s) from whom the data were obtained. In addition, the data will be protected by the NIH Certificate of Confidentiality. + +Prior to transferring data to the HTAN DCC, members are responsible for fully deidentifying the data being transferred. Full deidentification of data includes confirmation that data file names do not contain any information that could be used to re-identify that data subject. + + diff --git a/data_pub_submission/Data_Liaisons.md b/data_pub_submission/Data_Liaisons.md index d8bf9a34..a7ed41d8 100644 --- a/data_pub_submission/Data_Liaisons.md +++ b/data_pub_submission/Data_Liaisons.md @@ -4,7 +4,7 @@ order: 997 # Data Liaisons -Upon joining HTAN, Centers are assigned a data liaison from the DCC; Trans-Network Projects (TNPs) are also assigned liaisons. The DCC liaisons assist each of the research centers in successfully uploading data and metadata files. +Upon joining HTAN, Centers are assigned a data liaison from the DCC. Trans-Network Projects (TNPs) are also assigned liaisons. The DCC liaisons assist each of the research centers in successfully uploading data and metadata files. Here is the current list of centers, their atlases and DCC liaisons: From 4d201553c99270d7119790e92c45c6108562113a Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 14:30:44 -0500 Subject: [PATCH 016/176] data de-id section information added. --- data_pub_submission/Data_Deidentification.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data_pub_submission/Data_Deidentification.md b/data_pub_submission/Data_Deidentification.md index e1878d91..0f9c4097 100644 --- a/data_pub_submission/Data_Deidentification.md +++ b/data_pub_submission/Data_Deidentification.md @@ -4,7 +4,7 @@ order: 998 # Data Deidentification -** HTAN Centers are responsible for data deidentification. ** +**HTAN Centers are responsible for data deidentification.** As outlined in the HTAN [DMSA](https://docs.google.com/document/d/1RPFm9MBJv8DjZmYZyIv0jbjtNJ8fnwGjYDjlK4lL4nc/edit#heading=h.gjdgxs), data submitted to the Data Coordinating Center (DCC) must be fully de-identified. From f2250cdec404f70b38b13757683b63d0ba0d4951 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 14:31:40 -0500 Subject: [PATCH 017/176] data de-id section information added. --- data_pub_submission/Data_Deidentification.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data_pub_submission/Data_Deidentification.md b/data_pub_submission/Data_Deidentification.md index 0f9c4097..56a69a2b 100644 --- a/data_pub_submission/Data_Deidentification.md +++ b/data_pub_submission/Data_Deidentification.md @@ -4,7 +4,7 @@ order: 998 # Data Deidentification -**HTAN Centers are responsible for data deidentification.** +:exclamation: **HTAN Centers are responsible for data deidentification.** As outlined in the HTAN [DMSA](https://docs.google.com/document/d/1RPFm9MBJv8DjZmYZyIv0jbjtNJ8fnwGjYDjlK4lL4nc/edit#heading=h.gjdgxs), data submitted to the Data Coordinating Center (DCC) must be fully de-identified. From 81af845f00e14cfca1a287053067b9c0cc604f88 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 14:33:04 -0500 Subject: [PATCH 018/176] data de-id section information added. --- data_pub_submission/Data_Deidentification.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data_pub_submission/Data_Deidentification.md b/data_pub_submission/Data_Deidentification.md index 56a69a2b..8d39990c 100644 --- a/data_pub_submission/Data_Deidentification.md +++ b/data_pub_submission/Data_Deidentification.md @@ -4,7 +4,7 @@ order: 998 # Data Deidentification -:exclamation: **HTAN Centers are responsible for data deidentification.** +:warning: **HTAN Centers are responsible for data deidentification.** As outlined in the HTAN [DMSA](https://docs.google.com/document/d/1RPFm9MBJv8DjZmYZyIv0jbjtNJ8fnwGjYDjlK4lL4nc/edit#heading=h.gjdgxs), data submitted to the Data Coordinating Center (DCC) must be fully de-identified. From d4c6d9381561295070e701490c42c7ec659917fe Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 14:34:03 -0500 Subject: [PATCH 019/176] data de-id section information added. --- data_pub_submission/Data_Deidentification.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data_pub_submission/Data_Deidentification.md b/data_pub_submission/Data_Deidentification.md index 8d39990c..3956063e 100644 --- a/data_pub_submission/Data_Deidentification.md +++ b/data_pub_submission/Data_Deidentification.md @@ -8,7 +8,7 @@ order: 998 As outlined in the HTAN [DMSA](https://docs.google.com/document/d/1RPFm9MBJv8DjZmYZyIv0jbjtNJ8fnwGjYDjlK4lL4nc/edit#heading=h.gjdgxs), data submitted to the Data Coordinating Center (DCC) must be fully de-identified. -By signing this DMSA, HTAN members’ institutional signing officials and PIs accept responsibility for the deidentification of data prior to transfer to the DCC and confirm that: (a) all data disclosed to the DCC (Synapse) are fully de-identified in accordance with HIPAA, (b) all data were collected in accordance with protocols approved by an IRB or its equivalent, (c) all data are consistent with applicable U.S. laws, regulations, and its institutional policies and (d) that an IRB/Privacy Board or equivalent body has assured that submission and subsequent sharing of data are consistent with the Informed Consent of the Data Subject(s) from whom the data were obtained. In addition, the data will be protected by the NIH Certificate of Confidentiality. +By signing the HTAN DMSA, HTAN members’ institutional signing officials and PIs accept responsibility for the deidentification of data prior to transfer to the DCC and confirm that: (a) all data disclosed to the DCC (Synapse) are fully de-identified in accordance with HIPAA, (b) all data were collected in accordance with protocols approved by an IRB or its equivalent, (c) all data are consistent with applicable U.S. laws, regulations, and its institutional policies and (d) that an IRB/Privacy Board or equivalent body has assured that submission and subsequent sharing of data are consistent with the Informed Consent of the Data Subject(s) from whom the data were obtained. In addition, the data will be protected by the NIH Certificate of Confidentiality. Prior to transferring data to the HTAN DCC, members are responsible for fully deidentifying the data being transferred. Full deidentification of data includes confirmation that data file names do not contain any information that could be used to re-identify that data subject. From aad21a557ddc065b96275209afa65db1be49ec3a Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 14:43:58 -0500 Subject: [PATCH 020/176] updates to data_pub_submission overview --- data_pub_submission/overview.md | 6 ++++++ 1 file changed, 6 insertions(+) diff --git a/data_pub_submission/overview.md b/data_pub_submission/overview.md index 0d4545ae..932ce76b 100644 --- a/data_pub_submission/overview.md +++ b/data_pub_submission/overview.md @@ -5,6 +5,12 @@ order: 1000 # Data and Publication Submission Overview Only HTAN Centers and Associate Members can submit data to the HTAN Network's repositories. The Data Submission Section of this Manual is intended as a guide for HTAN Centers and Associate Members. +:exclamation: Note: Prior to submitting data, all data must be de-identified. Please see [Data Deidentification](../data_pub_submission/Data_Deidentification.md) for more information. +Data Submission Involves Two Key Steps: +1. UpLoading data files to Synapse; and +2. Completing and validating manifests using the Data Curator App (DCA). +The DCA is also used to submit HTAN-associated publications. +Please contact your [Data Liaison](../data_pub_submission/Data_Liaisons.md) if you have any questions or issues. Please also keep your data liaison informed of any data or publication submissions. \ No newline at end of file From dda8c86be197b5e573731ada32dda944b070d694 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 14:45:36 -0500 Subject: [PATCH 021/176] updates to data_pub_submission data de-id --- data_pub_submission/Data_Deidentification.md | 7 ++++++- 1 file changed, 6 insertions(+), 1 deletion(-) diff --git a/data_pub_submission/Data_Deidentification.md b/data_pub_submission/Data_Deidentification.md index 3956063e..1c7a9038 100644 --- a/data_pub_submission/Data_Deidentification.md +++ b/data_pub_submission/Data_Deidentification.md @@ -8,7 +8,12 @@ order: 998 As outlined in the HTAN [DMSA](https://docs.google.com/document/d/1RPFm9MBJv8DjZmYZyIv0jbjtNJ8fnwGjYDjlK4lL4nc/edit#heading=h.gjdgxs), data submitted to the Data Coordinating Center (DCC) must be fully de-identified. -By signing the HTAN DMSA, HTAN members’ institutional signing officials and PIs accept responsibility for the deidentification of data prior to transfer to the DCC and confirm that: (a) all data disclosed to the DCC (Synapse) are fully de-identified in accordance with HIPAA, (b) all data were collected in accordance with protocols approved by an IRB or its equivalent, (c) all data are consistent with applicable U.S. laws, regulations, and its institutional policies and (d) that an IRB/Privacy Board or equivalent body has assured that submission and subsequent sharing of data are consistent with the Informed Consent of the Data Subject(s) from whom the data were obtained. In addition, the data will be protected by the NIH Certificate of Confidentiality. +By signing the HTAN DMSA, HTAN members’ institutional signing officials and PIs accept responsibility for the deidentification of data prior to transfer to the DCC and confirm that: + +(a) all data disclosed to the DCC (Synapse) are fully de-identified in accordance with HIPAA; +(b) all data were collected in accordance with protocols approved by an IRB or its equivalent; +(c) all data are consistent with applicable U.S. laws, regulations, and its institutional policies; and +(d) that an IRB/Privacy Board or equivalent body has assured that submission and subsequent sharing of data are consistent with the Informed Consent of the Data Subject(s) from whom the data were obtained. In addition, the data will be protected by the NIH Certificate of Confidentiality. Prior to transferring data to the HTAN DCC, members are responsible for fully deidentifying the data being transferred. Full deidentification of data includes confirmation that data file names do not contain any information that could be used to re-identify that data subject. From 9596b37672a828acc7dcd7d419568a5dbbb652dd Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 14:46:06 -0500 Subject: [PATCH 022/176] updates to data_pub_submission data de-id --- data_pub_submission/Data_Deidentification.md | 3 +++ 1 file changed, 3 insertions(+) diff --git a/data_pub_submission/Data_Deidentification.md b/data_pub_submission/Data_Deidentification.md index 1c7a9038..1bf6e14f 100644 --- a/data_pub_submission/Data_Deidentification.md +++ b/data_pub_submission/Data_Deidentification.md @@ -11,8 +11,11 @@ As outlined in the HTAN [DMSA](https://docs.google.com/document/d/1RPFm9MBJv8DjZ By signing the HTAN DMSA, HTAN members’ institutional signing officials and PIs accept responsibility for the deidentification of data prior to transfer to the DCC and confirm that: (a) all data disclosed to the DCC (Synapse) are fully de-identified in accordance with HIPAA; + (b) all data were collected in accordance with protocols approved by an IRB or its equivalent; + (c) all data are consistent with applicable U.S. laws, regulations, and its institutional policies; and + (d) that an IRB/Privacy Board or equivalent body has assured that submission and subsequent sharing of data are consistent with the Informed Consent of the Data Subject(s) from whom the data were obtained. In addition, the data will be protected by the NIH Certificate of Confidentiality. Prior to transferring data to the HTAN DCC, members are responsible for fully deidentifying the data being transferred. Full deidentification of data includes confirmation that data file names do not contain any information that could be used to re-identify that data subject. From b618771c4ada923ca8219156247772705345b7e4 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 14:46:37 -0500 Subject: [PATCH 023/176] updates to data_pub_submission data de-id --- data_pub_submission/Data_Deidentification.md | 8 ++++---- 1 file changed, 4 insertions(+), 4 deletions(-) diff --git a/data_pub_submission/Data_Deidentification.md b/data_pub_submission/Data_Deidentification.md index 1bf6e14f..4acbc159 100644 --- a/data_pub_submission/Data_Deidentification.md +++ b/data_pub_submission/Data_Deidentification.md @@ -10,13 +10,13 @@ As outlined in the HTAN [DMSA](https://docs.google.com/document/d/1RPFm9MBJv8DjZ By signing the HTAN DMSA, HTAN members’ institutional signing officials and PIs accept responsibility for the deidentification of data prior to transfer to the DCC and confirm that: -(a) all data disclosed to the DCC (Synapse) are fully de-identified in accordance with HIPAA; + (a) all data disclosed to the DCC (Synapse) are fully de-identified in accordance with HIPAA; -(b) all data were collected in accordance with protocols approved by an IRB or its equivalent; + (b) all data were collected in accordance with protocols approved by an IRB or its equivalent; -(c) all data are consistent with applicable U.S. laws, regulations, and its institutional policies; and + (c) all data are consistent with applicable U.S. laws, regulations, and its institutional policies; and -(d) that an IRB/Privacy Board or equivalent body has assured that submission and subsequent sharing of data are consistent with the Informed Consent of the Data Subject(s) from whom the data were obtained. In addition, the data will be protected by the NIH Certificate of Confidentiality. + (d) that an IRB/Privacy Board or equivalent body has assured that submission and subsequent sharing of data are consistent with the Informed Consent of the Data Subject(s) from whom the data were obtained. In addition, the data will be protected by the NIH Certificate of Confidentiality. Prior to transferring data to the HTAN DCC, members are responsible for fully deidentifying the data being transferred. Full deidentification of data includes confirmation that data file names do not contain any information that could be used to re-identify that data subject. From c45a02ccb070959acad83ed70382399d6793a877 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 14:48:21 -0500 Subject: [PATCH 024/176] updates to data_pub_submission data de-id --- data_pub_submission/Data_Deidentification.md | 4 +++- 1 file changed, 3 insertions(+), 1 deletion(-) diff --git a/data_pub_submission/Data_Deidentification.md b/data_pub_submission/Data_Deidentification.md index 4acbc159..99bd2a19 100644 --- a/data_pub_submission/Data_Deidentification.md +++ b/data_pub_submission/Data_Deidentification.md @@ -16,7 +16,9 @@ By signing the HTAN DMSA, HTAN members’ institutional signing officials and PI (c) all data are consistent with applicable U.S. laws, regulations, and its institutional policies; and - (d) that an IRB/Privacy Board or equivalent body has assured that submission and subsequent sharing of data are consistent with the Informed Consent of the Data Subject(s) from whom the data were obtained. In addition, the data will be protected by the NIH Certificate of Confidentiality. + (d) that an IRB/Privacy Board or equivalent body has assured that submission and subsequent sharing + of data are consistent with the Informed Consent of the Data Subject(s) from whom the data were obtained. + In addition, the data will be protected by the NIH Certificate of Confidentiality. Prior to transferring data to the HTAN DCC, members are responsible for fully deidentifying the data being transferred. Full deidentification of data includes confirmation that data file names do not contain any information that could be used to re-identify that data subject. From a5772082b32b778f7a5fecb4114530c0147de1f7 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 14:50:00 -0500 Subject: [PATCH 025/176] updates to data_pub_submission data de-id, overview --- data_pub_submission/Information_New_Centers.md | 2 +- data_pub_submission/overview.md | 2 +- 2 files changed, 2 insertions(+), 2 deletions(-) diff --git a/data_pub_submission/Information_New_Centers.md b/data_pub_submission/Information_New_Centers.md index c90fd077..5c2b6426 100644 --- a/data_pub_submission/Information_New_Centers.md +++ b/data_pub_submission/Information_New_Centers.md @@ -14,4 +14,4 @@ HTAN Centers are assigned a [data liaison](../data_pub_submission/Data_Liaisons. Please see the appropriate page of this manual for additional details about HTAN center responsibilities for data de-identification and specific instructions regarding how to submit data. Clinical, biospecimen, and assay data submitted to the DCC are distributed to repositories based on access levels. Information regarding how data are accessed by external users is described more in [other parts of this manual](../overview/data_levels.md). -In order to support the FAIR (Findability, Accessibility, Interoperability, and Reusability) principles for scientific data production, the DCC has developed a [data model](../data_model/) based on established standards in the scientific research community. The HTAN Data Model is expected to evolve with advances in science. This evolution is a community-driven, peer-reviewed process, where members of a working group will first assess established community data standards and create a request for comment (RFC) document soliciting community feedback. Adding new data types and the RFC process are described in more detail in later pages of this manual. We look forward to working with you and learning from your expertise as we improve upon our current model. +In order to support the FAIR (Findability, Accessibility, Interoperability, and Reusability) principles for scientific data production, the DCC has developed a [data model](../data_model/) based on established standards in the scientific research community. The HTAN Data Model is expected to evolve with advances in science. This evolution is a community-driven, peer-reviewed process, where members of a working group will first assess established community data standards and create a request for comment (RFC) document soliciting community feedback. The RFC process is described in more detail in later pages of this manual. We look forward to working with you and learning from your expertise as we improve upon our current model. diff --git a/data_pub_submission/overview.md b/data_pub_submission/overview.md index 932ce76b..563c4896 100644 --- a/data_pub_submission/overview.md +++ b/data_pub_submission/overview.md @@ -5,7 +5,7 @@ order: 1000 # Data and Publication Submission Overview Only HTAN Centers and Associate Members can submit data to the HTAN Network's repositories. The Data Submission Section of this Manual is intended as a guide for HTAN Centers and Associate Members. -:exclamation: Note: Prior to submitting data, all data must be de-identified. Please see [Data Deidentification](../data_pub_submission/Data_Deidentification.md) for more information. +:exclamation: *Prior to submitting data, all data must be de-identified. Please see [Data Deidentification](../data_pub_submission/Data_Deidentification.md) for more information.* Data Submission Involves Two Key Steps: 1. UpLoading data files to Synapse; and From 2735dd21b1b402cc2fa8176bc2a3a2aaaf6be985 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 14:51:51 -0500 Subject: [PATCH 026/176] updates to data_pub_submission data de-id, overview --- data_pub_submission/overview.md | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/data_pub_submission/overview.md b/data_pub_submission/overview.md index 563c4896..6eacc6f0 100644 --- a/data_pub_submission/overview.md +++ b/data_pub_submission/overview.md @@ -8,9 +8,9 @@ Only HTAN Centers and Associate Members can submit data to the HTAN Network's re :exclamation: *Prior to submitting data, all data must be de-identified. Please see [Data Deidentification](../data_pub_submission/Data_Deidentification.md) for more information.* Data Submission Involves Two Key Steps: -1. UpLoading data files to Synapse; and +1. Uploading data files to Synapse; and 2. Completing and validating manifests using the Data Curator App (DCA). The DCA is also used to submit HTAN-associated publications. -Please contact your [Data Liaison](../data_pub_submission/Data_Liaisons.md) if you have any questions or issues. Please also keep your data liaison informed of any data or publication submissions. \ No newline at end of file +Specific details regarding uploading data files and the DCA are included in later sections of this manial. Please contact your [Data Liaison](../data_pub_submission/Data_Liaisons.md) if you have any questions or issues. Please also keep your data liaison informed of any data or publication submissions. \ No newline at end of file From 5e99563ca31370b0cd8c04252f4f03e402c98c82 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 15:25:32 -0500 Subject: [PATCH 027/176] submitting clin biosp and assay data section --- data_pub_submission/clin_biospec_assay.md | 71 +++++++++++++++++++++++ data_pub_submission/overview.md | 2 +- 2 files changed, 72 insertions(+), 1 deletion(-) create mode 100644 data_pub_submission/clin_biospec_assay.md diff --git a/data_pub_submission/clin_biospec_assay.md b/data_pub_submission/clin_biospec_assay.md new file mode 100644 index 00000000..fe0c7e61 --- /dev/null +++ b/data_pub_submission/clin_biospec_assay.md @@ -0,0 +1,71 @@ +--- +order: 996 +--- + +# Submitting Clinical, Biospecimen or Assay Data + +As stated in the [Data and Publication Submission Overview](../data_pub_submission/overview.md), data submission involves two key steps: +1. Uploading data files to Synapse; and +2. Completing and validating manifests using the Data Curator App (DCA). + +This page provides more details regarding those steps. However, you will also need to understand the HTAN data model and specific requirements for your particular data type. For a general overview of the HTAN data model, please see [HTAN Data Model](../data_model.md). To understand specific requirements for your data type, please see [Data Standards](https://humantumoratlas.org/standards). + +HTAN uses the Synapse [Web Portal](https:/www.synapse.org) and [DCA](https://dca.app.sagebionetworks.org/) to manage clinical, biospecimen and assay data submissions (dataset ingress). In order to submit data, your center should: + +1. [Have at least one user with Certified User status on Synapse.](#have-at-least-one-user-with-certified-user-status-on-synapse) +2. [Contact your Data Liaison](#contact-your-data-liaison-to-set-up-a-project-on-synapse) to: + a. set up a project on Synapse for metadata submission; + b. set up a Synapse cloud bucket for dataset uploads; and + c. create an HTAN atlas ID (only needs to be done once per atlas). +3. [Ensure the assay dataset conforms to the HTAN Data Model, uses HTAN Identifiers and does not contain Protected Health Information (PHI).](#ensure-the-dataset-conforms-to-the-htan-data-model-uses-htan-identifiers-and-does-not-contain-phi) +4. [Organize the data.](#organize-the-data) +5. [Upload your assay dataset to Synapse.](#upload-your-dataset-to-the-synapse-project) +6. [Validate and submit metadata using the DCA.](#validate-and-submit-metadata-using-synapses-data-curator-app-dca) + +Please read the rest of this page for more information about each of these steps. + +## Have at least one user with Certified User status on Synapse. +To upload files to Synapse, you need to be a [certified user](https://help.synapse.org/docs/Synapse-User-Account-Types.2007072795.html). Because Synapse stores data from human subjects research, Sage Bionetworks requires that you demonstrate understanding of and compliance with privacy and security issues. You can complete your certification by taking a [short certification quiz](https://www.synapse.org/#!Quiz:Certification) on Synapse. + +## Contact your Data Liaison to set up a project on Synapse. + +When you are ready to upload data, please contact your [data liaison](add internal link here). Your data liaison will need to know: +1. Your center +2. Who on your team will be doing the data upload. +3. The synapse usernames for team members identified in #2. + +With the above information, the DCC will initialize your Synapse project and storage location. Once your Synapse project has been initialized, your data liaison will reach out to you with the location of your Synapse project and you can begin uploading your data. + +## Ensure the dataset conforms to the HTAN Data Model, uses HTAN Identifiers and does not contain PHI. + +The HTAN Data Model is built upon data standards described on the ["Data Standards"](https://data.humantumoratlas.org/standards) page. All HTAN Centers are required to encode their clinical, biospecimen and assay data and metadata using the HTAN Data Model. If you have a new data type which is not currently represented in the HTAN Data Model, please contact your data liaison. + +A concrete way to understand the expectations for data submissions is to view the metadata templates for clinical, biospecimen and assay data available in Synapse's Data Curator App ([DCA](https://dca-docs.scrollhelp.site/DCA/Working-version/HTAN/)). For any given dataset, you may be submitting: + +- clinical data metadata(s) +- biospecimen metadata(s) +- assay metadata +- assay data files + +The first three items will be validated and submitted using the Data Curator App. The last item, assay data files, only needs to be uploaded to the synapse project itself. + +All data should be identified using HTAN identifiers. Please see the [HTAN Identifier SOP](https://docs.google.com/document/d/1podtPP8L1UNvVxx9_c_szlDcU1f8n7bige6XA_GoRVM/edit?usp=sharing) for detailed instructions regarding assigning HTAN Identifiers. + +*Please review your data to ensure that it does not contain PHI.* + +## Organize the data + +Please organize your data in the following manner. + +:exclamation: :exclamation: Need more information here. (does HTAN use the flattened or hierarchy format?) + +## Upload your dataset to the Synapse Project. + +Data files can be transferred using the Synapse User Interface (Synapse UI) or programmatically. Please see Synapse's [Data Ingress Docs](https://dca-docs.scrollhelp.site/DCA/Working-version/HTAN/uploading-data) for more information on how to upload files. + + +## Validate and submit metadata using Synapse's Data Curator App (DCA). + +The DCA contains HTAN-specific metadata templates which can be completed on the app or downloaded. Once these are completed by your center, they should then be validated and submitted via the DCA. + +Please see Synapse's [Data Ingress Docs](https://dca-docs.scrollhelp.site/DCA/Working-version/HTAN/validate-and-submit-your-metadata) for more details regarding the web app. diff --git a/data_pub_submission/overview.md b/data_pub_submission/overview.md index 6eacc6f0..9e742c03 100644 --- a/data_pub_submission/overview.md +++ b/data_pub_submission/overview.md @@ -7,7 +7,7 @@ Only HTAN Centers and Associate Members can submit data to the HTAN Network's re :exclamation: *Prior to submitting data, all data must be de-identified. Please see [Data Deidentification](../data_pub_submission/Data_Deidentification.md) for more information.* -Data Submission Involves Two Key Steps: +Data Submission involves two key steps: 1. Uploading data files to Synapse; and 2. Completing and validating manifests using the Data Curator App (DCA). From a6ae79cb2312204a18f595c93bfa0653c2d3c4af Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 15:27:34 -0500 Subject: [PATCH 028/176] more edits for clin biospec assay sub. --- data_pub_submission/clin_biospec_assay.md | 4 +++- 1 file changed, 3 insertions(+), 1 deletion(-) diff --git a/data_pub_submission/clin_biospec_assay.md b/data_pub_submission/clin_biospec_assay.md index fe0c7e61..6e14790a 100644 --- a/data_pub_submission/clin_biospec_assay.md +++ b/data_pub_submission/clin_biospec_assay.md @@ -14,9 +14,11 @@ HTAN uses the Synapse [Web Portal](https:/www.synapse.org) and [DCA](https://dca 1. [Have at least one user with Certified User status on Synapse.](#have-at-least-one-user-with-certified-user-status-on-synapse) 2. [Contact your Data Liaison](#contact-your-data-liaison-to-set-up-a-project-on-synapse) to: + a. set up a project on Synapse for metadata submission; b. set up a Synapse cloud bucket for dataset uploads; and c. create an HTAN atlas ID (only needs to be done once per atlas). + 3. [Ensure the assay dataset conforms to the HTAN Data Model, uses HTAN Identifiers and does not contain Protected Health Information (PHI).](#ensure-the-dataset-conforms-to-the-htan-data-model-uses-htan-identifiers-and-does-not-contain-phi) 4. [Organize the data.](#organize-the-data) 5. [Upload your assay dataset to Synapse.](#upload-your-dataset-to-the-synapse-project) @@ -27,7 +29,7 @@ Please read the rest of this page for more information about each of these steps ## Have at least one user with Certified User status on Synapse. To upload files to Synapse, you need to be a [certified user](https://help.synapse.org/docs/Synapse-User-Account-Types.2007072795.html). Because Synapse stores data from human subjects research, Sage Bionetworks requires that you demonstrate understanding of and compliance with privacy and security issues. You can complete your certification by taking a [short certification quiz](https://www.synapse.org/#!Quiz:Certification) on Synapse. -## Contact your Data Liaison to set up a project on Synapse. +## Contact your Data Liaison. When you are ready to upload data, please contact your [data liaison](add internal link here). Your data liaison will need to know: 1. Your center From 4595c9ea38116f932e9cb4580ac89aca4a806cf2 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 15:28:13 -0500 Subject: [PATCH 029/176] more edits for clin biospec assay sub. --- data_pub_submission/clin_biospec_assay.md | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/data_pub_submission/clin_biospec_assay.md b/data_pub_submission/clin_biospec_assay.md index 6e14790a..3a148c29 100644 --- a/data_pub_submission/clin_biospec_assay.md +++ b/data_pub_submission/clin_biospec_assay.md @@ -13,12 +13,12 @@ This page provides more details regarding those steps. However, you will also n HTAN uses the Synapse [Web Portal](https:/www.synapse.org) and [DCA](https://dca.app.sagebionetworks.org/) to manage clinical, biospecimen and assay data submissions (dataset ingress). In order to submit data, your center should: 1. [Have at least one user with Certified User status on Synapse.](#have-at-least-one-user-with-certified-user-status-on-synapse) -2. [Contact your Data Liaison](#contact-your-data-liaison-to-set-up-a-project-on-synapse) to: +2. [Contact your Data Liaison](#contact-your-data-liaison) to: a. set up a project on Synapse for metadata submission; b. set up a Synapse cloud bucket for dataset uploads; and c. create an HTAN atlas ID (only needs to be done once per atlas). - + 3. [Ensure the assay dataset conforms to the HTAN Data Model, uses HTAN Identifiers and does not contain Protected Health Information (PHI).](#ensure-the-dataset-conforms-to-the-htan-data-model-uses-htan-identifiers-and-does-not-contain-phi) 4. [Organize the data.](#organize-the-data) 5. [Upload your assay dataset to Synapse.](#upload-your-dataset-to-the-synapse-project) From c22fc570071e10d31748cd1a227d7829d464fd97 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 15:33:38 -0500 Subject: [PATCH 030/176] more edits for clin biospec assay sub. --- data_pub_submission/clin_biospec_assay.md | 21 +++++++++------------ 1 file changed, 9 insertions(+), 12 deletions(-) diff --git a/data_pub_submission/clin_biospec_assay.md b/data_pub_submission/clin_biospec_assay.md index 3a148c29..1d00f07d 100644 --- a/data_pub_submission/clin_biospec_assay.md +++ b/data_pub_submission/clin_biospec_assay.md @@ -13,12 +13,7 @@ This page provides more details regarding those steps. However, you will also n HTAN uses the Synapse [Web Portal](https:/www.synapse.org) and [DCA](https://dca.app.sagebionetworks.org/) to manage clinical, biospecimen and assay data submissions (dataset ingress). In order to submit data, your center should: 1. [Have at least one user with Certified User status on Synapse.](#have-at-least-one-user-with-certified-user-status-on-synapse) -2. [Contact your Data Liaison](#contact-your-data-liaison) to: - - a. set up a project on Synapse for metadata submission; - b. set up a Synapse cloud bucket for dataset uploads; and - c. create an HTAN atlas ID (only needs to be done once per atlas). - +2. [Contact your Data Liaison to set up your project and cloud bucket.](#contact-your-data-liaison-to-set-up-your-project-and-cloud-bucket) 3. [Ensure the assay dataset conforms to the HTAN Data Model, uses HTAN Identifiers and does not contain Protected Health Information (PHI).](#ensure-the-dataset-conforms-to-the-htan-data-model-uses-htan-identifiers-and-does-not-contain-phi) 4. [Organize the data.](#organize-the-data) 5. [Upload your assay dataset to Synapse.](#upload-your-dataset-to-the-synapse-project) @@ -29,14 +24,16 @@ Please read the rest of this page for more information about each of these steps ## Have at least one user with Certified User status on Synapse. To upload files to Synapse, you need to be a [certified user](https://help.synapse.org/docs/Synapse-User-Account-Types.2007072795.html). Because Synapse stores data from human subjects research, Sage Bionetworks requires that you demonstrate understanding of and compliance with privacy and security issues. You can complete your certification by taking a [short certification quiz](https://www.synapse.org/#!Quiz:Certification) on Synapse. -## Contact your Data Liaison. +## Contact your Data Liaison to set up your project and cloud bucket. -When you are ready to upload data, please contact your [data liaison](add internal link here). Your data liaison will need to know: +When you are ready to upload data, please contact your [data liaison](../data_pub_submission/Data_Liaisons.md). Your data liaison will need to know: 1. Your center 2. Who on your team will be doing the data upload. 3. The synapse usernames for team members identified in #2. -With the above information, the DCC will initialize your Synapse project and storage location. Once your Synapse project has been initialized, your data liaison will reach out to you with the location of your Synapse project and you can begin uploading your data. +Please have users obtain certified user status prior to contacting your data liaison. + +With the above information, the DCC will initialize your Synapse project for metadata submission and a cloud storage location for dataset uploads. If the data submission is for a new atlas, the DCC will also create an HTAN atlas ID. Once your Synapse project has been initialized, your data liaison will reach out to you with the location of your Synapse project and you can begin uploading your data. ## Ensure the dataset conforms to the HTAN Data Model, uses HTAN Identifiers and does not contain PHI. @@ -44,9 +41,9 @@ The HTAN Data Model is built upon data standards described on the ["Data Standar A concrete way to understand the expectations for data submissions is to view the metadata templates for clinical, biospecimen and assay data available in Synapse's Data Curator App ([DCA](https://dca-docs.scrollhelp.site/DCA/Working-version/HTAN/)). For any given dataset, you may be submitting: -- clinical data metadata(s) -- biospecimen metadata(s) -- assay metadata +- clinical data metadata template(s) +- biospecimen metadata template(s) +- assay metadata template(s) - assay data files The first three items will be validated and submitted using the Data Curator App. The last item, assay data files, only needs to be uploaded to the synapse project itself. From f72e0c4a739c28de9aebc9c7408c697e91c15050 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 15:44:17 -0500 Subject: [PATCH 031/176] format edits data de-id --- data_pub_submission/Data_Deidentification.md | 10 ++++------ data_pub_submission/clin_biospec_assay.md | 4 ++-- 2 files changed, 6 insertions(+), 8 deletions(-) diff --git a/data_pub_submission/Data_Deidentification.md b/data_pub_submission/Data_Deidentification.md index 99bd2a19..81c0b900 100644 --- a/data_pub_submission/Data_Deidentification.md +++ b/data_pub_submission/Data_Deidentification.md @@ -10,15 +10,13 @@ As outlined in the HTAN [DMSA](https://docs.google.com/document/d/1RPFm9MBJv8DjZ By signing the HTAN DMSA, HTAN members’ institutional signing officials and PIs accept responsibility for the deidentification of data prior to transfer to the DCC and confirm that: - (a) all data disclosed to the DCC (Synapse) are fully de-identified in accordance with HIPAA; +- all data disclosed to the DCC (Synapse) are fully de-identified in accordance with HIPAA; - (b) all data were collected in accordance with protocols approved by an IRB or its equivalent; +- all data were collected in accordance with protocols approved by an IRB or its equivalent; - (c) all data are consistent with applicable U.S. laws, regulations, and its institutional policies; and +- all data are consistent with applicable U.S. laws, regulations, and its institutional policies; and - (d) that an IRB/Privacy Board or equivalent body has assured that submission and subsequent sharing - of data are consistent with the Informed Consent of the Data Subject(s) from whom the data were obtained. - In addition, the data will be protected by the NIH Certificate of Confidentiality. +- that an IRB/Privacy Board or equivalent body has assured that submission and subsequent sharing of data are consistent with the Informed Consent of the Data Subject(s) from whom the data were obtained. In addition, the data will be protected by the NIH Certificate of Confidentiality. Prior to transferring data to the HTAN DCC, members are responsible for fully deidentifying the data being transferred. Full deidentification of data includes confirmation that data file names do not contain any information that could be used to re-identify that data subject. diff --git a/data_pub_submission/clin_biospec_assay.md b/data_pub_submission/clin_biospec_assay.md index 1d00f07d..67ed10dc 100644 --- a/data_pub_submission/clin_biospec_assay.md +++ b/data_pub_submission/clin_biospec_assay.md @@ -16,13 +16,13 @@ HTAN uses the Synapse [Web Portal](https:/www.synapse.org) and [DCA](https://dca 2. [Contact your Data Liaison to set up your project and cloud bucket.](#contact-your-data-liaison-to-set-up-your-project-and-cloud-bucket) 3. [Ensure the assay dataset conforms to the HTAN Data Model, uses HTAN Identifiers and does not contain Protected Health Information (PHI).](#ensure-the-dataset-conforms-to-the-htan-data-model-uses-htan-identifiers-and-does-not-contain-phi) 4. [Organize the data.](#organize-the-data) -5. [Upload your assay dataset to Synapse.](#upload-your-dataset-to-the-synapse-project) +5. [Upload your dataset to Synapse.](#upload-your-dataset-to-the-synapse-project) 6. [Validate and submit metadata using the DCA.](#validate-and-submit-metadata-using-synapses-data-curator-app-dca) Please read the rest of this page for more information about each of these steps. ## Have at least one user with Certified User status on Synapse. -To upload files to Synapse, you need to be a [certified user](https://help.synapse.org/docs/Synapse-User-Account-Types.2007072795.html). Because Synapse stores data from human subjects research, Sage Bionetworks requires that you demonstrate understanding of and compliance with privacy and security issues. You can complete your certification by taking a [short certification quiz](https://www.synapse.org/#!Quiz:Certification) on Synapse. +To upload files to Synapse, you need to be a [certified user](https://help.synapse.org/docs/Synapse-User-Account-Types.2007072795.html). Because Synapse stores data from human subjects research, Sage Bionetworks requires that you demonstrate understanding of and compliance with privacy and security issues. You can complete your certification by taking a short certification quiz. Please see the Synapse [certified user documentation](https://help.synapse.org/docs/Synapse-User-Account-Types.2007072795.html) for more inforamtion. ## Contact your Data Liaison to set up your project and cloud bucket. From 2309c46b7e26f702d989145dd73e075f0a6305cf Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 15:47:47 -0500 Subject: [PATCH 032/176] minor formatting edits. --- data_pub_submission/clin_biospec_assay.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data_pub_submission/clin_biospec_assay.md b/data_pub_submission/clin_biospec_assay.md index 67ed10dc..66a12423 100644 --- a/data_pub_submission/clin_biospec_assay.md +++ b/data_pub_submission/clin_biospec_assay.md @@ -50,7 +50,7 @@ The first three items will be validated and submitted using the Data Curator App All data should be identified using HTAN identifiers. Please see the [HTAN Identifier SOP](https://docs.google.com/document/d/1podtPP8L1UNvVxx9_c_szlDcU1f8n7bige6XA_GoRVM/edit?usp=sharing) for detailed instructions regarding assigning HTAN Identifiers. -*Please review your data to ensure that it does not contain PHI.* +:warning: *Please review your data to ensure that it does not contain PHI.* ## Organize the data From 8ad63f29013cc3e704a71d91f59321e738ea6658 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 15:54:45 -0500 Subject: [PATCH 033/176] adding publications.md --- data_pub_submission/clin_biospec_assay.md | 2 +- data_pub_submission/publications.md | 11 +++++++++++ 2 files changed, 12 insertions(+), 1 deletion(-) create mode 100644 data_pub_submission/publications.md diff --git a/data_pub_submission/clin_biospec_assay.md b/data_pub_submission/clin_biospec_assay.md index 66a12423..131a80c9 100644 --- a/data_pub_submission/clin_biospec_assay.md +++ b/data_pub_submission/clin_biospec_assay.md @@ -39,7 +39,7 @@ With the above information, the DCC will initialize your Synapse project for met The HTAN Data Model is built upon data standards described on the ["Data Standards"](https://data.humantumoratlas.org/standards) page. All HTAN Centers are required to encode their clinical, biospecimen and assay data and metadata using the HTAN Data Model. If you have a new data type which is not currently represented in the HTAN Data Model, please contact your data liaison. -A concrete way to understand the expectations for data submissions is to view the metadata templates for clinical, biospecimen and assay data available in Synapse's Data Curator App ([DCA](https://dca-docs.scrollhelp.site/DCA/Working-version/HTAN/)). For any given dataset, you may be submitting: +A concrete way to understand the expectations for data submissions is to view the metadata templates for clinical, biospecimen and assay data available in Synapse's Data Curator App ([DCA](https://dca.app.sagebionetworks.org/)). For any given dataset, you may be submitting: - clinical data metadata template(s) - biospecimen metadata template(s) diff --git a/data_pub_submission/publications.md b/data_pub_submission/publications.md new file mode 100644 index 00000000..069192bd --- /dev/null +++ b/data_pub_submission/publications.md @@ -0,0 +1,11 @@ +--- +order: 995 +--- + +# Submitting Publications + +Publications are submitted to HTAN via the publications metadata template on Synapse Data Curator App ([DCA](https://dca.app.sagebionetworks.org/)). To access the DCA, you must be a Synapse [certified user](https://help.synapse.org/docs/Synapse-User-Account-Types.2007072795.html). + +The metadata template will facilitate linking a HTAN publication to the specimen and assay files used in the publication. + +:exclamation: :exclamation: *Please note: In order to support data sharing and public data access, publications should either use HTAN identifiers or provide a lookup table to map publication identifiers to HTAN identifiers.* From 72229df2702d3dd744a03967467486b7fbb5a3a9 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 15:55:37 -0500 Subject: [PATCH 034/176] minor format change --- data_pub_submission/publications.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data_pub_submission/publications.md b/data_pub_submission/publications.md index 069192bd..3ed509e0 100644 --- a/data_pub_submission/publications.md +++ b/data_pub_submission/publications.md @@ -8,4 +8,4 @@ Publications are submitted to HTAN via the publications metadata template on Syn The metadata template will facilitate linking a HTAN publication to the specimen and assay files used in the publication. -:exclamation: :exclamation: *Please note: In order to support data sharing and public data access, publications should either use HTAN identifiers or provide a lookup table to map publication identifiers to HTAN identifiers.* +:exclamation: *Please note: In order to support data sharing and public data access, publications should either use HTAN identifiers or provide a lookup table to map publication identifiers to HTAN identifiers.* From 8e5ef1f74e9ad8e96a627aa3e1c892168746d01c Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 15:58:39 -0500 Subject: [PATCH 035/176] main page changes --- readme.md | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/readme.md b/readme.md index ee84c94d..ff236607 100644 --- a/readme.md +++ b/readme.md @@ -1,10 +1,10 @@ -# HTAN: The Missing Manual +# The HTAN Manual Written by the HTAN Data Coordinating Center (DCC), with contributions from Adam Taylor, Clarisse Lau, Vésteinn Thorsson, Ino de Bruijn, David Gibbs, Ethan Cerami and Alex Lash. ## About this Manual -**HTAN: The Missing Manual** provides an overview of Human Tumor Atlas Network (HTAN) data and the various modes of data access. If you have any questions regarding the manual or HTAN data, please contact us at: htan@googlegroups.com. +**The HTAN Manual** provides an overview of Human Tumor Atlas Network (HTAN) data, including the various levels of data access. If you have any questions regarding the manual or HTAN data, please contact us at: htan@googlegroups.com. The manual can be found at https://docs.humantumoratlas.org/. From c81060a5fcf237a00bc5cfda3fa7dc9174fd936d Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 12 Jan 2024 17:12:02 -0500 Subject: [PATCH 036/176] minor chg main readme --- readme.md | 3 ++- 1 file changed, 2 insertions(+), 1 deletion(-) diff --git a/readme.md b/readme.md index ff236607..3f5cc6c0 100644 --- a/readme.md +++ b/readme.md @@ -12,6 +12,7 @@ The manual can be found at https://docs.humantumoratlas.org/. | Date | Comment | |------------|--------------------------| +| | Third version of manual | | 2023-06-01 | Second version of manual | -| 2022-09-28 | First version of manual. | +| 2022-09-28 | First version of manual | From 2cb8f7d90255da7ddd5857efc68b72d8dd26e59f Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 16 Jan 2024 09:41:41 -0500 Subject: [PATCH 037/176] Minor edits to data_pub_submission sections. --- data_pub_submission/Data_Deidentification.md | 6 +++--- data_pub_submission/Information_New_Centers.md | 2 +- data_pub_submission/clin_biospec_assay.md | 4 ++-- data_pub_submission/overview.md | 4 ++-- 4 files changed, 8 insertions(+), 8 deletions(-) diff --git a/data_pub_submission/Data_Deidentification.md b/data_pub_submission/Data_Deidentification.md index 81c0b900..47690cc0 100644 --- a/data_pub_submission/Data_Deidentification.md +++ b/data_pub_submission/Data_Deidentification.md @@ -2,13 +2,13 @@ order: 998 --- -# Data Deidentification +# Data De-identification :warning: **HTAN Centers are responsible for data deidentification.** As outlined in the HTAN [DMSA](https://docs.google.com/document/d/1RPFm9MBJv8DjZmYZyIv0jbjtNJ8fnwGjYDjlK4lL4nc/edit#heading=h.gjdgxs), data submitted to the Data Coordinating Center (DCC) must be fully de-identified. -By signing the HTAN DMSA, HTAN members’ institutional signing officials and PIs accept responsibility for the deidentification of data prior to transfer to the DCC and confirm that: +By signing the HTAN DMSA, HTAN members’ institutional signing officials and PIs accept responsibility for the de-identification of data prior to transfer to the DCC and confirm that: - all data disclosed to the DCC (Synapse) are fully de-identified in accordance with HIPAA; @@ -18,6 +18,6 @@ By signing the HTAN DMSA, HTAN members’ institutional signing officials and PI - that an IRB/Privacy Board or equivalent body has assured that submission and subsequent sharing of data are consistent with the Informed Consent of the Data Subject(s) from whom the data were obtained. In addition, the data will be protected by the NIH Certificate of Confidentiality. -Prior to transferring data to the HTAN DCC, members are responsible for fully deidentifying the data being transferred. Full deidentification of data includes confirmation that data file names do not contain any information that could be used to re-identify that data subject. +Prior to transferring data to the HTAN DCC, members are responsible for fully de-identifying the data being transferred. Full de-identification of data includes confirmation that data file names do not contain any information that could be used to re-identify that data subject. diff --git a/data_pub_submission/Information_New_Centers.md b/data_pub_submission/Information_New_Centers.md index 5c2b6426..9f4629fb 100644 --- a/data_pub_submission/Information_New_Centers.md +++ b/data_pub_submission/Information_New_Centers.md @@ -6,7 +6,7 @@ order: 999 Welcome to the HTAN Network! -Documents provided on the HTAN [resources page](https://humantumoratlas.org/resources) will help you understand requirements for publications, data sharing and data use. +Documents provided on the HTAN [resources page](https://humantumoratlas.org/resources) detail requirements for publications, data sharing and data use. All HTAN members must have an executed Human Tumor Atlas Network DMSA (Internal Data and Materials Sharing Agreement) [(HTAN DMSA)](https://docs.google.com/document/d/1RPFm9MBJv8DjZmYZyIv0jbjtNJ8fnwGjYDjlK4lL4nc/edit) with Sage Bionetworks prior to contributing or accessing data in the HTAN DCC. To initiate execution of the HTAN DMSA, contact Sage HTAN Governance (htan@sagebionetworks.jira.com). Please include the name and contact information of your HTAN PI and Institution Signatory to enable routing the HTAN DMSA for execution. diff --git a/data_pub_submission/clin_biospec_assay.md b/data_pub_submission/clin_biospec_assay.md index 131a80c9..7800ea2b 100644 --- a/data_pub_submission/clin_biospec_assay.md +++ b/data_pub_submission/clin_biospec_assay.md @@ -4,7 +4,7 @@ order: 996 # Submitting Clinical, Biospecimen or Assay Data -As stated in the [Data and Publication Submission Overview](../data_pub_submission/overview.md), data submission involves two key steps: +As stated in [Data and Publication Submission Overview](../data_pub_submission/overview.md), data submission involves two key steps: 1. Uploading data files to Synapse; and 2. Completing and validating manifests using the Data Curator App (DCA). @@ -37,7 +37,7 @@ With the above information, the DCC will initialize your Synapse project for met ## Ensure the dataset conforms to the HTAN Data Model, uses HTAN Identifiers and does not contain PHI. -The HTAN Data Model is built upon data standards described on the ["Data Standards"](https://data.humantumoratlas.org/standards) page. All HTAN Centers are required to encode their clinical, biospecimen and assay data and metadata using the HTAN Data Model. If you have a new data type which is not currently represented in the HTAN Data Model, please contact your data liaison. +The HTAN Data Model is built upon data standards described on the [Data Standards](https://data.humantumoratlas.org/standards) page. All HTAN Centers are required to encode their clinical, biospecimen and assay data and metadata using the HTAN Data Model. If you have a new data type which is not currently represented in the HTAN Data Model, please contact your data liaison. A concrete way to understand the expectations for data submissions is to view the metadata templates for clinical, biospecimen and assay data available in Synapse's Data Curator App ([DCA](https://dca.app.sagebionetworks.org/)). For any given dataset, you may be submitting: diff --git a/data_pub_submission/overview.md b/data_pub_submission/overview.md index 9e742c03..63528e97 100644 --- a/data_pub_submission/overview.md +++ b/data_pub_submission/overview.md @@ -11,6 +11,6 @@ Data Submission involves two key steps: 1. Uploading data files to Synapse; and 2. Completing and validating manifests using the Data Curator App (DCA). -The DCA is also used to submit HTAN-associated publications. +HTAN-associated publications are also submitted by completing and validating a manifest using the DCA. -Specific details regarding uploading data files and the DCA are included in later sections of this manial. Please contact your [Data Liaison](../data_pub_submission/Data_Liaisons.md) if you have any questions or issues. Please also keep your data liaison informed of any data or publication submissions. \ No newline at end of file +Specific details regarding data submission and the DCA are included in later sections of this manial. Please contact your [Data Liaison](../data_pub_submission/Data_Liaisons.md) if you have any questions or issues. Please also keep your data liaison informed of any data or publication submissions. \ No newline at end of file From 188e11f1f085fa1f3ac6961cc5ae7c46a7f4b308 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 16 Jan 2024 10:12:59 -0500 Subject: [PATCH 038/176] Start of additional information. --- addtnl_info/RFC.md | 6 ++++++ addtnl_info/WG_internal.md | 7 +++++++ addtnl_info/data_release.md | 7 +++++++ addtnl_info/index.yml | 2 +- addtnl_info/tool_protocol.md | 10 ++++++++++ tool_protocol_submission/index.yml | 2 -- 6 files changed, 31 insertions(+), 3 deletions(-) create mode 100644 addtnl_info/RFC.md create mode 100644 addtnl_info/WG_internal.md create mode 100644 addtnl_info/data_release.md create mode 100644 addtnl_info/tool_protocol.md delete mode 100644 tool_protocol_submission/index.yml diff --git a/addtnl_info/RFC.md b/addtnl_info/RFC.md new file mode 100644 index 00000000..44f7dd5b --- /dev/null +++ b/addtnl_info/RFC.md @@ -0,0 +1,6 @@ +--- +order: 997 +--- + +# The RFC Process + diff --git a/addtnl_info/WG_internal.md b/addtnl_info/WG_internal.md new file mode 100644 index 00000000..2827419e --- /dev/null +++ b/addtnl_info/WG_internal.md @@ -0,0 +1,7 @@ +--- +order: 998 +--- + +# Working Groups and Internal Communications + +Information regarding Network Working Groups and Internal Communications can be found on [HTAN's Synapse Wiki page](https://www.synapse.org/#!Synapse:syn17022193/wiki/584990). Access to the HTAN Wiki is restricted to HTAN Members. Please contact :exclamation: ________________ :exclamation" if you a member of HTAN and need access to the wiki. \ No newline at end of file diff --git a/addtnl_info/data_release.md b/addtnl_info/data_release.md new file mode 100644 index 00000000..84f72d9e --- /dev/null +++ b/addtnl_info/data_release.md @@ -0,0 +1,7 @@ +--- +order: 999 +--- + +# Data Release + +HTAN releases data at regular intervals. HTAN Centers are notified of the data submission deadline for an upcoming data release. Then the data release itself involves a number of data processing and verification steps. Please see [HTAN Data Release Process](https://docs.google.com/document/d/15xvIbfyQmgbMD_uB2e0SwPFw67_AePB5YspF4dsilCA/edit#heading=h.tddsmkcn4p1p) for more information regarding the data release process. \ No newline at end of file diff --git a/addtnl_info/index.yml b/addtnl_info/index.yml index 187f0a42..ff50be84 100644 --- a/addtnl_info/index.yml +++ b/addtnl_info/index.yml @@ -1,2 +1,2 @@ label: Additional Information -order: 994 +order: 995 diff --git a/addtnl_info/tool_protocol.md b/addtnl_info/tool_protocol.md new file mode 100644 index 00000000..c0c056b0 --- /dev/null +++ b/addtnl_info/tool_protocol.md @@ -0,0 +1,10 @@ +--- +order: 1000 +--- + +# Tool and Protocol Curation + +Computational tools developed or used to support HTAN research projects can be added to the HTAN tool catalog by filling out the tool curation form available on [HTAN's Synapse Wiki page](https://www.synapse.org/#!Synapse:syn17022193/wiki/584990). Please contact :exclamation: ________________ :exclamation" if you a member of HTAN and need access to the wiki. + +:exclamation: Need information regarding how protols are developed/shared. + diff --git a/tool_protocol_submission/index.yml b/tool_protocol_submission/index.yml deleted file mode 100644 index e6f37677..00000000 --- a/tool_protocol_submission/index.yml +++ /dev/null @@ -1,2 +0,0 @@ -label: Tool and Protocol Submissions -order: 995 From 62c167136e29ae8c3d18db4dc7e6053004a81097 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 16 Jan 2024 10:15:35 -0500 Subject: [PATCH 039/176] Minor edits, additional info sections. --- addtnl_info/WG_internal.md | 2 +- addtnl_info/data_release.md | 2 +- addtnl_info/tool_protocol.md | 2 +- 3 files changed, 3 insertions(+), 3 deletions(-) diff --git a/addtnl_info/WG_internal.md b/addtnl_info/WG_internal.md index 2827419e..1935ec4a 100644 --- a/addtnl_info/WG_internal.md +++ b/addtnl_info/WG_internal.md @@ -4,4 +4,4 @@ order: 998 # Working Groups and Internal Communications -Information regarding Network Working Groups and Internal Communications can be found on [HTAN's Synapse Wiki page](https://www.synapse.org/#!Synapse:syn17022193/wiki/584990). Access to the HTAN Wiki is restricted to HTAN Members. Please contact :exclamation: ________________ :exclamation" if you a member of HTAN and need access to the wiki. \ No newline at end of file +Information regarding Network Working Groups and Internal Communications can be found on [HTAN's Synapse Wiki page](https://www.synapse.org/#!Synapse:syn17022193/wiki/584990). Access to the HTAN Wiki is restricted to HTAN Members. Please contact :exclamation: ________________ :exclamation: if you a member of HTAN and need access to the wiki. \ No newline at end of file diff --git a/addtnl_info/data_release.md b/addtnl_info/data_release.md index 84f72d9e..2f745c67 100644 --- a/addtnl_info/data_release.md +++ b/addtnl_info/data_release.md @@ -4,4 +4,4 @@ order: 999 # Data Release -HTAN releases data at regular intervals. HTAN Centers are notified of the data submission deadline for an upcoming data release. Then the data release itself involves a number of data processing and verification steps. Please see [HTAN Data Release Process](https://docs.google.com/document/d/15xvIbfyQmgbMD_uB2e0SwPFw67_AePB5YspF4dsilCA/edit#heading=h.tddsmkcn4p1p) for more information regarding the data release process. \ No newline at end of file +HTAN releases data at regular intervals. HTAN Centers are notified of the data submission deadline for an upcoming data release. After that deadline, the data release itself involves a number of data processing and verification steps. Please see [HTAN Data Release Process](https://docs.google.com/document/d/15xvIbfyQmgbMD_uB2e0SwPFw67_AePB5YspF4dsilCA/edit#heading=h.tddsmkcn4p1p) for more information regarding the data release process. \ No newline at end of file diff --git a/addtnl_info/tool_protocol.md b/addtnl_info/tool_protocol.md index c0c056b0..f0ac8f04 100644 --- a/addtnl_info/tool_protocol.md +++ b/addtnl_info/tool_protocol.md @@ -4,7 +4,7 @@ order: 1000 # Tool and Protocol Curation -Computational tools developed or used to support HTAN research projects can be added to the HTAN tool catalog by filling out the tool curation form available on [HTAN's Synapse Wiki page](https://www.synapse.org/#!Synapse:syn17022193/wiki/584990). Please contact :exclamation: ________________ :exclamation" if you a member of HTAN and need access to the wiki. +Computational tools developed or used to support HTAN research projects can be added to the HTAN tool catalog by filling out the tool curation form available on [HTAN's Synapse Wiki page](https://www.synapse.org/#!Synapse:syn17022193/wiki/584990). Please contact :exclamation: ________________ :exclamation: if you a member of HTAN and need access to the wiki. :exclamation: Need information regarding how protols are developed/shared. From 1c97ed3120f8400bf0f0cd84f2492848ebc1b33d Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 16 Jan 2024 10:35:05 -0500 Subject: [PATCH 040/176] RFC edits. --- addtnl_info/RFC.md | 49 +++++++++++++++++++++++++++++++++++++++++++++- 1 file changed, 48 insertions(+), 1 deletion(-) diff --git a/addtnl_info/RFC.md b/addtnl_info/RFC.md index 44f7dd5b..e4ece674 100644 --- a/addtnl_info/RFC.md +++ b/addtnl_info/RFC.md @@ -2,5 +2,52 @@ order: 997 --- -# The RFC Process +# The RFC Process and Data Model Changes + +## RFC Overview +The HTAN Data Model is expected to evolve with advances in science. This evolution is a community-driven, peer-reviewed process, where members of a working group will first assess established community data standards and create a request for comment (RFC) document soliciting community feedback. + +The status of current RFCs is provided in [The RFC Overview](https://docs.google.com/document/d/1dJ7NUoVCtewdtny8bITwtWnzItB4IibL5kJO3ZNh0go/edit?usp=sharing) document. The RFC Overview can be used to: + +- Get a sense of what is available in DCA. +- Get a sense of new assays being considered. +- Look at old RFCs & get a sense of past discussions/considerations. + +:exclamation: The links to specific RFC documents within the RFC Overview do **not** represent the final data model. Once an RFC is available on the Data Curator App (DCA), the metadata template available on the DCA and HTAN's [Data Standards page](https://humantumoratlas.org/standards) contain the current data model. + +## Data Model Changes +New assays or data types do not always require data model changes and an RFC. + +The following generally do not require a change to the Data Model: + +- New assays which are specific to only one center or will only be used in a limited capacity. These can often be accommodated as “Other Assay”. +- Additional, optional free text metadata fields. Additional columns can be added to your copy of the metadata template if they do not require validation by the Data Curator App. + +The following require changes to the Data Model and would need to undergo the Request for Comments (RFC) process: + +- New assay types which are expected to be used frequently by multiple centers. +- New metadata templates or additional required metadata fields which should be validated. + +Please contact your [data liaison](../data_pub_submission/Data_Liaisons.md) for help determining whether a Data Model change is needed and how to make a Data Model change request. + +## RFC Process + +Once a new assay type or a set of needed Data Model changes are identified, the following steps are taken: + +1. A working group is organized* by the Data Coordinating Center (DCC). As a part of this process, the following people are also designated: + * A *DCC Owner*, who is responsible for finalizing the RFC and overall accepting/rejecting/integrating community feedback. The DCC Owner is also the primary point of contact for the specified RFC. + * A *single DCC PI*, to monitor progress towards completion. + * One or more *Co-Authors* from one or more HTAN centers, to help draft the RFC. Representatives from each HTAN center help identify individuals at their center who can contribute to a particular RFC. +2. A first draft of an RFC Google Document is created* based upon feedback from the working group. +3. *The RFC is open for public comment*. All HTAN members can provide suggestions by adding comments directly to the document. +4. After a designated period of time, the *RFC is closed*. Feedback from HTAN community is no longer accepted. The content of the RFC will be reflected in the respective version of the HTAN Data Model used for validating metadata files uploaded to the DCC. +5. The *metadata template is available on the [Data Curator App (DCA)*](https://dca.app.sagebionetworks.org/). + + + + + + + + From 1fd4a3c4ef630500218b4cec3d53cb3096925383 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 16 Jan 2024 10:39:17 -0500 Subject: [PATCH 041/176] RFC edits. --- addtnl_info/RFC.md | 6 +++--- 1 file changed, 3 insertions(+), 3 deletions(-) diff --git a/addtnl_info/RFC.md b/addtnl_info/RFC.md index e4ece674..d915929b 100644 --- a/addtnl_info/RFC.md +++ b/addtnl_info/RFC.md @@ -7,13 +7,13 @@ order: 997 ## RFC Overview The HTAN Data Model is expected to evolve with advances in science. This evolution is a community-driven, peer-reviewed process, where members of a working group will first assess established community data standards and create a request for comment (RFC) document soliciting community feedback. -The status of current RFCs is provided in [The RFC Overview](https://docs.google.com/document/d/1dJ7NUoVCtewdtny8bITwtWnzItB4IibL5kJO3ZNh0go/edit?usp=sharing) document. The RFC Overview can be used to: +The status of current RFCs is provided in the [RFC Overview](https://docs.google.com/document/d/1dJ7NUoVCtewdtny8bITwtWnzItB4IibL5kJO3ZNh0go/edit?usp=sharing) document. The RFC Overview can be used to: - Get a sense of what is available in DCA. - Get a sense of new assays being considered. - Look at old RFCs & get a sense of past discussions/considerations. -:exclamation: The links to specific RFC documents within the RFC Overview do **not** represent the final data model. Once an RFC is available on the Data Curator App (DCA), the metadata template available on the DCA and HTAN's [Data Standards page](https://humantumoratlas.org/standards) contain the current data model. +:exclamation::exclamation: The links to specific RFC documents within the RFC Overview do **not** represent the final data model. Once an RFC is available on the Data Curator App (DCA), the metadata template available on the DCA and HTAN's [Data Standards page](https://humantumoratlas.org/standards) contain the current data model. ## Data Model Changes New assays or data types do not always require data model changes and an RFC. @@ -41,7 +41,7 @@ Once a new assay type or a set of needed Data Model changes are identified, the 2. A first draft of an RFC Google Document is created* based upon feedback from the working group. 3. *The RFC is open for public comment*. All HTAN members can provide suggestions by adding comments directly to the document. 4. After a designated period of time, the *RFC is closed*. Feedback from HTAN community is no longer accepted. The content of the RFC will be reflected in the respective version of the HTAN Data Model used for validating metadata files uploaded to the DCC. -5. The *metadata template is available on the [Data Curator App (DCA)*](https://dca.app.sagebionetworks.org/). +5. *The metadata template is available on the [Data Curator App (DCA)](https://dca.app.sagebionetworks.org/).* From c60309200996bfde039ea0d3aeb62dd935c85e2e Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 16 Jan 2024 10:43:10 -0500 Subject: [PATCH 042/176] RFC edits. --- addtnl_info/RFC.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/addtnl_info/RFC.md b/addtnl_info/RFC.md index d915929b..0f3229db 100644 --- a/addtnl_info/RFC.md +++ b/addtnl_info/RFC.md @@ -13,7 +13,7 @@ The status of current RFCs is provided in the [RFC Overview](https://docs.google - Get a sense of new assays being considered. - Look at old RFCs & get a sense of past discussions/considerations. -:exclamation::exclamation: The links to specific RFC documents within the RFC Overview do **not** represent the final data model. Once an RFC is available on the Data Curator App (DCA), the metadata template available on the DCA and HTAN's [Data Standards page](https://humantumoratlas.org/standards) contain the current data model. +:exclamation::exclamation: The links to specific RFC documents within the RFC Overview do **not** represent the final data model. Once an RFC is closed and an assay is available on the Data Curator App (DCA), the metadata template on the DCA represents the final data model. Details regarding the data model are also available on HTAN's [Data Standards page](https://humantumoratlas.org/standards) and HTAN's [data-models repository](https://github.com/ncihtan/data-models) on github. ## Data Model Changes New assays or data types do not always require data model changes and an RFC. From adfda1d2ddb5daca656ce2e2645377a5e4d3b3c6 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 16 Jan 2024 10:53:09 -0500 Subject: [PATCH 043/176] Check adding imortant box --- data_pub_submission/Data_Deidentification.md | 2 +- overview/introduction.md | 4 +++- 2 files changed, 4 insertions(+), 2 deletions(-) diff --git a/data_pub_submission/Data_Deidentification.md b/data_pub_submission/Data_Deidentification.md index 47690cc0..53cd629e 100644 --- a/data_pub_submission/Data_Deidentification.md +++ b/data_pub_submission/Data_Deidentification.md @@ -4,7 +4,7 @@ order: 998 # Data De-identification -:warning: **HTAN Centers are responsible for data deidentification.** +[!IMPORTANT] **HTAN Centers are responsible for data deidentification.** As outlined in the HTAN [DMSA](https://docs.google.com/document/d/1RPFm9MBJv8DjZmYZyIv0jbjtNJ8fnwGjYDjlK4lL4nc/edit#heading=h.gjdgxs), data submitted to the Data Coordinating Center (DCC) must be fully de-identified. diff --git a/overview/introduction.md b/overview/introduction.md index 856ee75f..7f6dba1e 100644 --- a/overview/introduction.md +++ b/overview/introduction.md @@ -13,7 +13,9 @@ Each research center is responsible for gathering and processing samples, and ru All centers are required to submit their clinical, biospecimen and assay data to the HTAN DCC using a **common HTAN Data Model**. The DCC makes HTAN data available to the wider scientific community. !!! :zap: Important Links :zap: -Complete information regarding the HTAN network is available at: https://humantumoratlas.org/. +Complete information regarding HTAN is available at: https://humantumoratlas.org/. + +Please see [HTAN Data: A Gentle Introduction](https://cancerai.substack.com/p/htan-data-a-gentle-introduction) for an overview of HTAN Data. You can explore all open access data within the HTAN Data Portal at: https://humantumoratlas.org/explore. From 2b769a206af797bdb28e1d6cc10e400746e5d441 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 16 Jan 2024 10:54:28 -0500 Subject: [PATCH 044/176] Check adding imortant box --- data_pub_submission/Data_Deidentification.md | 4 +++- 1 file changed, 3 insertions(+), 1 deletion(-) diff --git a/data_pub_submission/Data_Deidentification.md b/data_pub_submission/Data_Deidentification.md index 53cd629e..37dd7bd1 100644 --- a/data_pub_submission/Data_Deidentification.md +++ b/data_pub_submission/Data_Deidentification.md @@ -4,7 +4,9 @@ order: 998 # Data De-identification -[!IMPORTANT] **HTAN Centers are responsible for data deidentification.** +!!! :warning: +**HTAN Centers are responsible for data deidentification.** +!!! As outlined in the HTAN [DMSA](https://docs.google.com/document/d/1RPFm9MBJv8DjZmYZyIv0jbjtNJ8fnwGjYDjlK4lL4nc/edit#heading=h.gjdgxs), data submitted to the Data Coordinating Center (DCC) must be fully de-identified. From 9adfaff64e0c223a50ede4d7199d954fa28cade5 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 16 Jan 2024 10:55:37 -0500 Subject: [PATCH 045/176] Check adding imortant box --- data_pub_submission/Data_Deidentification.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data_pub_submission/Data_Deidentification.md b/data_pub_submission/Data_Deidentification.md index 37dd7bd1..b9d3ba63 100644 --- a/data_pub_submission/Data_Deidentification.md +++ b/data_pub_submission/Data_Deidentification.md @@ -4,7 +4,7 @@ order: 998 # Data De-identification -!!! :warning: +!!! :warning: text :warning: **HTAN Centers are responsible for data deidentification.** !!! From cac996d70f5cc9865f3f9744e52cebeb5e973f22 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 16 Jan 2024 10:56:11 -0500 Subject: [PATCH 046/176] Check adding imortant box --- data_pub_submission/Data_Deidentification.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data_pub_submission/Data_Deidentification.md b/data_pub_submission/Data_Deidentification.md index b9d3ba63..37dd7bd1 100644 --- a/data_pub_submission/Data_Deidentification.md +++ b/data_pub_submission/Data_Deidentification.md @@ -4,7 +4,7 @@ order: 998 # Data De-identification -!!! :warning: text :warning: +!!! :warning: **HTAN Centers are responsible for data deidentification.** !!! From d93f60d7839b7eb4bb42c272e17a862c0bd7fd1a Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 16 Jan 2024 11:06:05 -0500 Subject: [PATCH 047/176] Check adding imortant box --- data_pub_submission/Data_Deidentification.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data_pub_submission/Data_Deidentification.md b/data_pub_submission/Data_Deidentification.md index 37dd7bd1..eba53da9 100644 --- a/data_pub_submission/Data_Deidentification.md +++ b/data_pub_submission/Data_Deidentification.md @@ -4,7 +4,7 @@ order: 998 # Data De-identification -!!! :warning: +!!! :warning: Important :warning: **HTAN Centers are responsible for data deidentification.** !!! From dc29c8ce17bb59e5186c1044e65193b5a731ed1c Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 16 Jan 2024 11:07:17 -0500 Subject: [PATCH 048/176] Check adding imortant box --- data_pub_submission/Data_Deidentification.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data_pub_submission/Data_Deidentification.md b/data_pub_submission/Data_Deidentification.md index eba53da9..bbb45f59 100644 --- a/data_pub_submission/Data_Deidentification.md +++ b/data_pub_submission/Data_Deidentification.md @@ -4,7 +4,7 @@ order: 998 # Data De-identification -!!! :warning: Important :warning: +!!! :exclamation: Important :exclamation: **HTAN Centers are responsible for data deidentification.** !!! From 560b3a660272e8149bc5a0c0c6528ab8c2b7e883 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 16 Jan 2024 11:08:08 -0500 Subject: [PATCH 049/176] Check adding imortant box --- data_pub_submission/Data_Deidentification.md | 3 +-- 1 file changed, 1 insertion(+), 2 deletions(-) diff --git a/data_pub_submission/Data_Deidentification.md b/data_pub_submission/Data_Deidentification.md index bbb45f59..dc0a89af 100644 --- a/data_pub_submission/Data_Deidentification.md +++ b/data_pub_submission/Data_Deidentification.md @@ -4,8 +4,7 @@ order: 998 # Data De-identification -!!! :exclamation: Important :exclamation: -**HTAN Centers are responsible for data deidentification.** +!!! **HTAN Centers are responsible for data deidentification.** !!! As outlined in the HTAN [DMSA](https://docs.google.com/document/d/1RPFm9MBJv8DjZmYZyIv0jbjtNJ8fnwGjYDjlK4lL4nc/edit#heading=h.gjdgxs), data submitted to the Data Coordinating Center (DCC) must be fully de-identified. From 58025b8132b1891c753e8431053c65a9a2a2b599 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 16 Jan 2024 11:09:41 -0500 Subject: [PATCH 050/176] RFC add box --- addtnl_info/RFC.md | 4 +++- 1 file changed, 3 insertions(+), 1 deletion(-) diff --git a/addtnl_info/RFC.md b/addtnl_info/RFC.md index 0f3229db..1675f02b 100644 --- a/addtnl_info/RFC.md +++ b/addtnl_info/RFC.md @@ -13,7 +13,9 @@ The status of current RFCs is provided in the [RFC Overview](https://docs.google - Get a sense of new assays being considered. - Look at old RFCs & get a sense of past discussions/considerations. -:exclamation::exclamation: The links to specific RFC documents within the RFC Overview do **not** represent the final data model. Once an RFC is closed and an assay is available on the Data Curator App (DCA), the metadata template on the DCA represents the final data model. Details regarding the data model are also available on HTAN's [Data Standards page](https://humantumoratlas.org/standards) and HTAN's [data-models repository](https://github.com/ncihtan/data-models) on github. +!!! +The links to specific RFC documents within the RFC Overview do **not** represent the final data model. Once an RFC is closed and an assay is available on the Data Curator App (DCA), the metadata template on the DCA represents the final data model. Details regarding the data model are also available on HTAN's [Data Standards page](https://humantumoratlas.org/standards) and HTAN's [data-models repository](https://github.com/ncihtan/data-models) on github. +!!! ## Data Model Changes New assays or data types do not always require data model changes and an RFC. From 649ef3627f9e75da21e100ad5723f86a1d6227d9 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 16 Jan 2024 11:11:53 -0500 Subject: [PATCH 051/176] RFC add box --- addtnl_info/RFC.md | 11 +---------- 1 file changed, 1 insertion(+), 10 deletions(-) diff --git a/addtnl_info/RFC.md b/addtnl_info/RFC.md index 1675f02b..98d31598 100644 --- a/addtnl_info/RFC.md +++ b/addtnl_info/RFC.md @@ -13,7 +13,7 @@ The status of current RFCs is provided in the [RFC Overview](https://docs.google - Get a sense of new assays being considered. - Look at old RFCs & get a sense of past discussions/considerations. -!!! +!!! Note: The links to specific RFC documents within the RFC Overview do **not** represent the final data model. Once an RFC is closed and an assay is available on the Data Curator App (DCA), the metadata template on the DCA represents the final data model. Details regarding the data model are also available on HTAN's [Data Standards page](https://humantumoratlas.org/standards) and HTAN's [data-models repository](https://github.com/ncihtan/data-models) on github. !!! @@ -44,12 +44,3 @@ Once a new assay type or a set of needed Data Model changes are identified, the 3. *The RFC is open for public comment*. All HTAN members can provide suggestions by adding comments directly to the document. 4. After a designated period of time, the *RFC is closed*. Feedback from HTAN community is no longer accepted. The content of the RFC will be reflected in the respective version of the HTAN Data Model used for validating metadata files uploaded to the DCC. 5. *The metadata template is available on the [Data Curator App (DCA)](https://dca.app.sagebionetworks.org/).* - - - - - - - - - From 15b50cded3e1b704df502baf13e78b5ef03e5f07 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 16 Jan 2024 12:02:23 -0500 Subject: [PATCH 052/176] removing assay specific info from data model --- data_model/biospecimens.md | 17 ---------------- data_model/clinical.md | 29 --------------------------- data_model/identifiers.md | 22 +++----------------- data_model/imaging.md | 22 -------------------- data_model/overview.md | 2 +- data_model/sequencing.md | 20 ------------------ data_model/spatial_transcriptomics.md | 20 ------------------ 7 files changed, 4 insertions(+), 128 deletions(-) delete mode 100644 data_model/biospecimens.md delete mode 100644 data_model/clinical.md delete mode 100644 data_model/imaging.md delete mode 100644 data_model/sequencing.md delete mode 100644 data_model/spatial_transcriptomics.md diff --git a/data_model/biospecimens.md b/data_model/biospecimens.md deleted file mode 100644 index cc8b7634..00000000 --- a/data_model/biospecimens.md +++ /dev/null @@ -1,17 +0,0 @@ ---- -order: 997 ---- - -# Biospecimen Metadata - -The HTAN biospecimen data model is designed to capture essential biospecimen data elements, including: - -- Acquisition method, e.g. autopsy, biopsy, fine needle aspirate, etc. -- Topography Code, indicating site within the body, e.g. based on [ICD-O-3](https://seer.cancer.gov/icd-o-3/). -- Collection information e.g. time, duration of ischemia, temperature, etc. -- Processing of parent biospecimen information e.g. fresh, frozen, etc. -- Biospecimen and derivative clinical metadata ie Histologic Morphology Code, e.g. based on [ICD-O-3](https://seer.cancer.gov/icd-o-3/). -- Coordinates for derivative biospecimen from their parent biospecimen. -- Processing of derivative biospecimen for downstream analysis e.g. dissociation, sectioning, analyte isolation, etc. - -Complete details are available online at: https://data.humantumoratlas.org/standard/biospecimen diff --git a/data_model/clinical.md b/data_model/clinical.md deleted file mode 100644 index 734a2675..00000000 --- a/data_model/clinical.md +++ /dev/null @@ -1,29 +0,0 @@ ---- -order: 998 ---- - -# Clinical Metadata - -The HTAN clinical data model consists of three tiers. Tier 1 is in alignment with the [Genomic Data Commons (GDC)](https://gdc.cancer.gov/) guidelines for clinical data, while Tiers 2 and 3 are HTAN extensions to the GDC model. - -| Tier | Notes | -| ---- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | -| 1 | Tier 1 is based entirely on the clinical data model used by the NCI Genomic Data Commons (GDC) [6]. It consists of seven categories of clinical data (see GDC Table below). | -| 2 | Disease-agnostic extensions to the GDC Clinical Data Model. | -| 3 | Disease-specific extensions to the GDC Clinical Data Model. This covers additional elements for Acute Lymphoblastic Leukemia (ALL), Brain Cancer, Breast Cancer, Lung Cancer, Melanoma, Ovarian Cancer, Pancreatic Cancer, Prostate Cancer and Sarcoma. | - -## GDC Clinical Data Model - -The GDC Clinical Data Model consists of seven categories of clinical data. - -| GDC Category | GDC Description | -| -------------- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | -| Demographics | Data for the characterization of the patient by means of segmenting the population (e.g., characterization by age, sex, or race). | -| Diagnosis | Data from the investigation, analysis and recognition of the presence and nature of disease, condition, or injury from expressed signs and symptoms; also, the scientific determination of any kind; the concise results of such an investigation. | -| Exposure | Clinically relevant patient information not immediately resulting from genetic predispositions. | -| Family History | Record of a patient's background regarding cancer events of blood relatives. | -| Follow-up | A visit by a patient or study participant to a medical professional. A clinical encounter that encompasses planned and unplanned trial interventions, procedures and assessments that may be performed on a subject. A visit has a start and an end, each described with a rule. The process by which information about the health status of an individual is obtained before and after a study has officially closed; an activity that continues something that has already begun or that repeats something that has already been done. | -| Molecular Test | Information pertaining to any molecular tests performed on the patient during a clinical event. | -| Therapy | Record of the administration and intention of therapeutic agents provided to a patient to alter the course of a pathologic process. | - -Complete details regarding all clinical data elements is available at: https://data.humantumoratlas.org/standard/clinical diff --git a/data_model/identifiers.md b/data_model/identifiers.md index cc8dcef2..3f93d79c 100644 --- a/data_model/identifiers.md +++ b/data_model/identifiers.md @@ -15,24 +15,8 @@ Research participants are identified with the following pattern: ::= _integer ``` -Where the `htan_center_id` is derived from the identifier prefix table below. - -| HTAN Center ID | Pilot Project or Contact PI Institution | -| -------------- | --------------------------------------- | -| HTA1 | HTAPP Pilot Project | -| HTA2 | PCAPP Pilot Project | -| HTA3 | Boston University | -| HTA4 | Children's Hospital of Philadelphia | -| HTA5 | Dana-Farber Cancer Institute | -| HTA6 | Duke University | -| HTA7 | Harvard Medical School | -| HTA8 | Memorial Sloan Kettering Cancer Center | -| HTA9 | Oregon Health Sciences University | -| HTA10 | Stanford University | -| HTA11 | Vanderbilt University | -| HTA12 | Washington University | -| HTA13 | TNP SARDANA | -| HTA14 | TNP TMA | +Where the `htan_center_id` is the HTAN Center Prefix. (e.g. HTA1, HTA2) Please see [HTAN Centers](../overview/centers.md) for a full list of HTAN Center prefixes. + Derivative data includes anything derived from a research participant, including biospecimens such as samples, tissue blocks, slides, aliquots, analytes, and data files that result from assaying those biospecimens. These identifiers follow the pattern: @@ -40,7 +24,7 @@ Derivative data includes anything derived from a research participant, including ::= _integer ``` -For example, if research participant 1 within the CHOP project has provided three samples, you would have three HTAN IDs, such as: +For example, if research participant 1 within the CHOP project (HTA4) shas provided three samples, you would have three HTAN IDs, such as: ``` HTA4_1_1 diff --git a/data_model/imaging.md b/data_model/imaging.md deleted file mode 100644 index 3ab7bfec..00000000 --- a/data_model/imaging.md +++ /dev/null @@ -1,22 +0,0 @@ ---- -order: 995 ---- - -# Imaging Data - -The HTAN data model for imaging data is based upon the [Minimum Information about Tissue Imaging (MITI)](https://www.miti-consortium.org/) reporting guidelines. These comprise minimal metadata for highly multiplexed tissue images and were developed in consultation with methods developers, experts in imaging metadata (e.g., DICOM and OME) and multiple large-scale atlas projects; they are guided by existing standards and accommodate most multiplexed imaging technologies and both centralized and distributed data storage. - -For further information on the MITI guidelines, please see the [MITI website](https://www.miti-consortium.org/), [specification on Github](https://github.com/miti-consortium/MITI), and [Nature Methods publication](https://www.nature.com/articles/s41592-022-01415-4). - -The HTAN data model for imaging was intended primarily for multiplexed imaging such as CODEX, CyCIF, and IMC, in addition to brightfield imaging of H&E stained tissues. - -As with Sequencing data, the imaging data model is split into data levels as follows: - -| Level | Description | -| ----- | -------------------------------------------------------------------------------------------------------------------------------------------------- | -| 1 | Raw imaging data requiring tiling, stitching, illumination correction, registration or other pre-processing. | -| 2 | Imaging data compiled into a single file format, preferably a tiled and pyramidal OME-TIFF. Accompanied by a csv file containing channel metadata. | -| 3 | Segmentation mask, Validated channel metadata, QC checked image. | -| 4 | An object-by-feature table (typically cell-by-marker) generated from the segmentation mask and image. | - -Before preparing imaging data for upload to DCC, please consult [HTAN Imaging Data Requirements](https://docs.google.com/document/d/1iNicigsSytekEQLkmeNJd2NOJ9VTKzBDfYj3BmvGcro/edit#heading=h.b6j67xcu50c2). diff --git a/data_model/overview.md b/data_model/overview.md index 45e654b0..82781736 100644 --- a/data_model/overview.md +++ b/data_model/overview.md @@ -9,5 +9,5 @@ All HTAN Centers are required to encode their data and metadata in the **common As much as possible, the HTAN Data Model leverages previously defined data standards across the scientific research community, including the [NCI Genomic Data Commons](https://gdc.cancer.gov/), the [Human Cell Atlas](https://www.humancellatlas.org/), the [Human Biomolecular Atlas Program (HuBMAP)](https://hubmapconsortium.org/) and the [Minimum Information about Tissue Imaging (MITI)](https://www.miti-consortium.org/) reporting guidelines. !!! Data Standards -Complete information regarding the HTAN Data Model is available at: https://data.humantumoratlas.org/standards. +Complete information regarding the HTAN Data Model and specific data elements is available at: https://data.humantumoratlas.org/standards. !!! diff --git a/data_model/sequencing.md b/data_model/sequencing.md deleted file mode 100644 index 64e6730f..00000000 --- a/data_model/sequencing.md +++ /dev/null @@ -1,20 +0,0 @@ ---- -order: 996 ---- - -# Sequencing Data - -HTAN supports multiple sequencing modalities including Single Cell and Single Nucleus RNA Seq (sc/snRNASeq), Single Cell ATAC Seq, Bulk RNA Seq and Bulk DNA Seq. - -The HTAN standard for gene annotations is [GENCODE Version 34](https://www.gencodegenes.org/human/release_34.html). [GENCODE](https://www.gencodegenes.org/) is used for gene definitions by many consortia, including ENCODE, NCI Genomic Data Commons, Human Cell Atlas, and PCAWG (Pan-Cancer Analysis of Whole Genomes). Ensembl gene content is essentially identical to that of GENCODE ([FAQ](https://www.gencodegenes.org/pages/faq.html)) and interconversion is possible. - -HTAN has adopted the [GENCODE 34](https://www.gencodegenes.org/human/release_34.html) Gene Transfer Format ([GTF](https://useast.ensembl.org/info/website/upload/gff.html)) comprehensive gene annotation file (GENCODE 34 GTF) and filtered files (GENCODE 34 GTF with genes only; GENCODE 34 GTF with genes only and retaining only chromosome X copy of pseudoautosomal region) for HTAN gene annotation. Note that HTAN also includes data generated with other gene models, as the process of implementing the standard is ongoing. Within HTAN metadata files, the reference genome used can be found in the attribute “Genomic Reference” and “Genomic Reference URL”. - -In alignment with The Cancer Genome Atlas and the NCI Genomic Data Commons, sequencing data are divided into four levels: - -| Level | Definition | Example Data | -| ----- | -------------------------- | ---------------------------------------- | -| 1 | Raw data | FASTQs, unaligned BAMs | -| 2 | Aligned primary data | Aligned BAMs | -| 3 | Derived biomolecular data | Gene expression matrix files, VCFs, etc. | -| 4 | Sample level summary data. | t-SNE plot coordinates, etc. | diff --git a/data_model/spatial_transcriptomics.md b/data_model/spatial_transcriptomics.md deleted file mode 100644 index ebac2531..00000000 --- a/data_model/spatial_transcriptomics.md +++ /dev/null @@ -1,20 +0,0 @@ ---- -order: 994 ---- - -# Spatial Transcriptomics - -The HTAN data model for spatial transcriptomics data is based upon both imaging and single cell sequencing data models. These form a collection of metadata fields where transcriptomic levels (or gene or protein level measures) can be mapped to locations on a tissue slide, and were developed in consultation with the data generating centers who are both experts in imaging metadata (e.g. DICOM and OME) and multiple large-scale atlas projects. - -The HTAN data model currently supports 10X Visium data, but additional platforms will be added in the near future including Nanostring GeoMX and Pick-Seq. - -Spatial transcriptomic datasets are typically comprised of RNA-sequencing data at varying levels, coupled with imaging data and an auxiliary set of files used in or generated by processing workflows for spatial transcriptomics: - -| Level | Description | -| --------------- | ------------------------------------------------------------------------------------------------------------------------------ | -| Spatial Transcriptomics RNA-seq Level 1 | Files contain raw RNA-seq data associated with spot/slide data. | -| Spatial Transcriptomics RNA-seq Level 2 | Alignment workflows downstream of Spatial Transcriptomics RNA-seq Level 1. | -| Spatial Transcriptomics RNA-seq Level 3 | Processed data files based on Spatial Transcriptomics RNA-seq Level 2 and Spatial Transcriptomics Auxiliary files. | -| Spatial Transcriptomics RNA-seq Level 4 | Processed data files based on Spatial Transcriptomics RNA-seq Level 3. | -| Spatial Transcriptomics Auxiliary Files | Auxiliary data associated with spot/slide analysis (aligned Images, quality control files, etc) from Spatial Transcriptomics. | -| Imaging Level 2 | Imaging data compiled into a single file format, preferably a tiled and pyramidal OME-TIFF. | From bc07a11f51554c53b16aa1404d4e87a115294c89 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 16 Jan 2024 12:04:48 -0500 Subject: [PATCH 053/176] change order of relationships.md --- data_model/relationships.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data_model/relationships.md b/data_model/relationships.md index 14a4d476..1284e0e9 100644 --- a/data_model/relationships.md +++ b/data_model/relationships.md @@ -1,5 +1,5 @@ --- -order: 993 +order: 998 --- # Relationship Model From a70b5fe4db443a15b626df72a44f61e8bd2ea957 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 16 Jan 2024 14:46:26 -0500 Subject: [PATCH 054/176] adding info box to clin biospec.. --- data_pub_submission/clin_biospec_assay.md | 3 ++- 1 file changed, 2 insertions(+), 1 deletion(-) diff --git a/data_pub_submission/clin_biospec_assay.md b/data_pub_submission/clin_biospec_assay.md index 7800ea2b..4518b723 100644 --- a/data_pub_submission/clin_biospec_assay.md +++ b/data_pub_submission/clin_biospec_assay.md @@ -50,7 +50,8 @@ The first three items will be validated and submitted using the Data Curator App All data should be identified using HTAN identifiers. Please see the [HTAN Identifier SOP](https://docs.google.com/document/d/1podtPP8L1UNvVxx9_c_szlDcU1f8n7bige6XA_GoRVM/edit?usp=sharing) for detailed instructions regarding assigning HTAN Identifiers. -:warning: *Please review your data to ensure that it does not contain PHI.* +!!! :warning: *Please review your data to ensure that it does not contain PHI.* +!!! ## Organize the data From 308970142dce151e04b26c7e00cecf62c7163eb3 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 16 Jan 2024 14:48:08 -0500 Subject: [PATCH 055/176] adding info box to clin biospec.. --- data_pub_submission/clin_biospec_assay.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data_pub_submission/clin_biospec_assay.md b/data_pub_submission/clin_biospec_assay.md index 4518b723..ea4e0295 100644 --- a/data_pub_submission/clin_biospec_assay.md +++ b/data_pub_submission/clin_biospec_assay.md @@ -50,7 +50,7 @@ The first three items will be validated and submitted using the Data Curator App All data should be identified using HTAN identifiers. Please see the [HTAN Identifier SOP](https://docs.google.com/document/d/1podtPP8L1UNvVxx9_c_szlDcU1f8n7bige6XA_GoRVM/edit?usp=sharing) for detailed instructions regarding assigning HTAN Identifiers. -!!! :warning: *Please review your data to ensure that it does not contain PHI.* +!!! *Please review your data to ensure that it does not contain PHI.* !!! ## Organize the data From e0b9a2daf7494f40816c45623fae582ce989eca8 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 16 Jan 2024 17:24:38 -0500 Subject: [PATCH 056/176] Minor edits data and pub submission --- data_pub_submission/overview.md | 2 +- data_pub_submission/publications.md | 3 ++- 2 files changed, 3 insertions(+), 2 deletions(-) diff --git a/data_pub_submission/overview.md b/data_pub_submission/overview.md index 63528e97..d42521ab 100644 --- a/data_pub_submission/overview.md +++ b/data_pub_submission/overview.md @@ -13,4 +13,4 @@ Data Submission involves two key steps: HTAN-associated publications are also submitted by completing and validating a manifest using the DCA. -Specific details regarding data submission and the DCA are included in later sections of this manial. Please contact your [Data Liaison](../data_pub_submission/Data_Liaisons.md) if you have any questions or issues. Please also keep your data liaison informed of any data or publication submissions. \ No newline at end of file +Specific details regarding data submission and the DCA are included in later sections of this manual. Please contact your [Data Liaison](../data_pub_submission/Data_Liaisons.md) if you have any questions or issues. Please also keep your data liaison informed of any data or publication submissions. \ No newline at end of file diff --git a/data_pub_submission/publications.md b/data_pub_submission/publications.md index 3ed509e0..15d70332 100644 --- a/data_pub_submission/publications.md +++ b/data_pub_submission/publications.md @@ -8,4 +8,5 @@ Publications are submitted to HTAN via the publications metadata template on Syn The metadata template will facilitate linking a HTAN publication to the specimen and assay files used in the publication. -:exclamation: *Please note: In order to support data sharing and public data access, publications should either use HTAN identifiers or provide a lookup table to map publication identifiers to HTAN identifiers.* +!!! *In order to support data sharing and public data access, publications should either use HTAN identifiers or provide a lookup table to map publication identifiers to HTAN identifiers.* +!!! From 25ea5027f019fc115af4891760bf87754b13eff1 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 16 Jan 2024 17:27:28 -0500 Subject: [PATCH 057/176] Minor edits data and pub submission --- data_pub_submission/publications.md | 4 +++- 1 file changed, 3 insertions(+), 1 deletion(-) diff --git a/data_pub_submission/publications.md b/data_pub_submission/publications.md index 15d70332..9a8cfdb8 100644 --- a/data_pub_submission/publications.md +++ b/data_pub_submission/publications.md @@ -8,5 +8,7 @@ Publications are submitted to HTAN via the publications metadata template on Syn The metadata template will facilitate linking a HTAN publication to the specimen and assay files used in the publication. -!!! *In order to support data sharing and public data access, publications should either use HTAN identifiers or provide a lookup table to map publication identifiers to HTAN identifiers.* +!!! *In order to support data sharing and public data access, publications should either: +* use HTAN identifiers; or +* provide a lookup table in the publication to map publication identifiers to HTAN identifiers.* !!! From b55236968161a794e493a80a5ab2452b3d3093c5 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 16 Jan 2024 17:29:13 -0500 Subject: [PATCH 058/176] Minor edits data and pub submission --- data_pub_submission/publications.md | 6 +++--- 1 file changed, 3 insertions(+), 3 deletions(-) diff --git a/data_pub_submission/publications.md b/data_pub_submission/publications.md index 9a8cfdb8..61a4fdab 100644 --- a/data_pub_submission/publications.md +++ b/data_pub_submission/publications.md @@ -8,7 +8,7 @@ Publications are submitted to HTAN via the publications metadata template on Syn The metadata template will facilitate linking a HTAN publication to the specimen and assay files used in the publication. -!!! *In order to support data sharing and public data access, publications should either: -* use HTAN identifiers; or -* provide a lookup table in the publication to map publication identifiers to HTAN identifiers.* +!!! *In order to support data sharing and public data access, publications should either:* +* *use HTAN identifiers; or* +* *provide a lookup table in the publication to map publication identifiers to HTAN identifiers.* !!! From 6002b98f365de58970e2c128238a1197f51ca6dd Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Wed, 17 Jan 2024 16:52:40 -0500 Subject: [PATCH 059/176] starting specific details page --- data_pub_submission/publications.md | 2 +- data_pub_submission/specific_details.md | 9 +++++++++ 2 files changed, 10 insertions(+), 1 deletion(-) create mode 100644 data_pub_submission/specific_details.md diff --git a/data_pub_submission/publications.md b/data_pub_submission/publications.md index 61a4fdab..36b77e53 100644 --- a/data_pub_submission/publications.md +++ b/data_pub_submission/publications.md @@ -1,5 +1,5 @@ --- -order: 995 +order: 994 --- # Submitting Publications diff --git a/data_pub_submission/specific_details.md b/data_pub_submission/specific_details.md new file mode 100644 index 00000000..cf4bee39 --- /dev/null +++ b/data_pub_submission/specific_details.md @@ -0,0 +1,9 @@ +--- +order: 995 +--- + +# Specific Assay/Data Element Details + +The following documents provide specific details regarding submitting clinical, biospecimen and assay data types. + +:warning: under development From 4c4d33763296f747324bdf5ecc85849602dd1acc Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Wed, 17 Jan 2024 16:57:02 -0500 Subject: [PATCH 060/176] update to specific details --- data_pub_submission/specific_details.md | 8 +++++++- 1 file changed, 7 insertions(+), 1 deletion(-) diff --git a/data_pub_submission/specific_details.md b/data_pub_submission/specific_details.md index cf4bee39..fb3a48f6 100644 --- a/data_pub_submission/specific_details.md +++ b/data_pub_submission/specific_details.md @@ -4,6 +4,12 @@ order: 995 # Specific Assay/Data Element Details -The following documents provide specific details regarding submitting clinical, biospecimen and assay data types. +The following documents provide specific submission details for each data type. Please see (Data Standards)[https://data.humantumoratlas.org/standards.] for an overview of HTAN Data Levels and Metadata Attributes for each data type. :warning: under development + +Clinical Data +Biospecimen +Sequencing + * Bulk RNA-seq + * Bulk DNA-seq From f9dc07585c28f3bce67fc0e0ffa1bc19fd804a50 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Mon, 22 Jan 2024 16:53:47 -0500 Subject: [PATCH 061/176] Grammar/other edits rfc.md --- addtnl_info/RFC.md | 18 +++++++++--------- 1 file changed, 9 insertions(+), 9 deletions(-) diff --git a/addtnl_info/RFC.md b/addtnl_info/RFC.md index 98d31598..f50cd2eb 100644 --- a/addtnl_info/RFC.md +++ b/addtnl_info/RFC.md @@ -23,7 +23,7 @@ New assays or data types do not always require data model changes and an RFC. The following generally do not require a change to the Data Model: - New assays which are specific to only one center or will only be used in a limited capacity. These can often be accommodated as “Other Assay”. -- Additional, optional free text metadata fields. Additional columns can be added to your copy of the metadata template if they do not require validation by the Data Curator App. +- Additional free text metadata fields. Additional columns can be added to your copy of the metadata template if they do not require validation by the Data Curator App. The following require changes to the Data Model and would need to undergo the Request for Comments (RFC) process: @@ -36,11 +36,11 @@ Please contact your [data liaison](../data_pub_submission/Data_Liaisons.md) for Once a new assay type or a set of needed Data Model changes are identified, the following steps are taken: -1. A working group is organized* by the Data Coordinating Center (DCC). As a part of this process, the following people are also designated: - * A *DCC Owner*, who is responsible for finalizing the RFC and overall accepting/rejecting/integrating community feedback. The DCC Owner is also the primary point of contact for the specified RFC. - * A *single DCC PI*, to monitor progress towards completion. - * One or more *Co-Authors* from one or more HTAN centers, to help draft the RFC. Representatives from each HTAN center help identify individuals at their center who can contribute to a particular RFC. -2. A first draft of an RFC Google Document is created* based upon feedback from the working group. -3. *The RFC is open for public comment*. All HTAN members can provide suggestions by adding comments directly to the document. -4. After a designated period of time, the *RFC is closed*. Feedback from HTAN community is no longer accepted. The content of the RFC will be reflected in the respective version of the HTAN Data Model used for validating metadata files uploaded to the DCC. -5. *The metadata template is available on the [Data Curator App (DCA)](https://dca.app.sagebionetworks.org/).* +1. **A working group is organized** by the Data Coordinating Center (DCC). As a part of this process, the following people are also designated: + * A **DCC Owner**, who is responsible for finalizing the RFC and overall accepting/rejecting/integrating community feedback. The DCC Owner is also the primary point of contact for the specified RFC. + * A **single DCC PI**, to monitor progress towards completion. + * One or more **Co-Authors** from one or more HTAN centers, to help draft the RFC. Representatives from each HTAN center help identify individuals at their center who can contribute to a particular RFC. +2. **A first draft of an RFC Google Document is created** based upon feedback from the working group. +3. **The RFC is open for public comment**. All HTAN members can provide suggestions by adding comments directly to the document. +4. After a designated period of time, the **RFC is closed**. Feedback from HTAN community is no longer accepted. The content of the RFC will be reflected in the respective version of the HTAN Data Model used for validating metadata files uploaded to the DCC. +5. **The metadata template is available on the [Data Curator App (DCA)](https://dca.app.sagebionetworks.org/).** From 4b2616a6981bb0758ed5f6b9671b1c023a96d7e3 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Mon, 22 Jan 2024 17:02:47 -0500 Subject: [PATCH 062/176] minor edits specific_details --- data_pub_submission/specific_details.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data_pub_submission/specific_details.md b/data_pub_submission/specific_details.md index fb3a48f6..84e85b06 100644 --- a/data_pub_submission/specific_details.md +++ b/data_pub_submission/specific_details.md @@ -4,7 +4,7 @@ order: 995 # Specific Assay/Data Element Details -The following documents provide specific submission details for each data type. Please see (Data Standards)[https://data.humantumoratlas.org/standards.] for an overview of HTAN Data Levels and Metadata Attributes for each data type. +The following documents provide specific submission details for each data type. Please see [Data Standards](https://data.humantumoratlas.org/standards) for an overview of HTAN Data Levels and Metadata Attributes for each data type. :warning: under development From 41d7f2474dfd8da9aff41b786a05bd3b416feeba Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 23 Jan 2024 09:41:05 -0500 Subject: [PATCH 063/176] specific details updates (links added). --- data_pub_submission/specific_details.md | 23 +++++++++++++++++------ 1 file changed, 17 insertions(+), 6 deletions(-) diff --git a/data_pub_submission/specific_details.md b/data_pub_submission/specific_details.md index 84e85b06..f220f2f2 100644 --- a/data_pub_submission/specific_details.md +++ b/data_pub_submission/specific_details.md @@ -4,12 +4,23 @@ order: 995 # Specific Assay/Data Element Details -The following documents provide specific submission details for each data type. Please see [Data Standards](https://data.humantumoratlas.org/standards) for an overview of HTAN Data Levels and Metadata Attributes for each data type. +Please see [Data Standards](https://data.humantumoratlas.org/standards) for an overview of HTAN Data Levels and Metadata Attributes for each data type. The following links provide specific submission details for each data type. -:warning: under development +!!! :warning: under development. +Please see Sequencing Data and Accessory Files below for example google docs with specific submission details. + +[Accessory Files](https://docs.google.com/document/d/1pCzpf1s7Oh91V9tIwTovvrQfBWRnUJHqe1XBz3K8NfM/edit?usp=sharing) -Clinical Data Biospecimen -Sequencing - * Bulk RNA-seq - * Bulk DNA-seq + +Clinical Data + +Imaging + +RPPR + +[Sequencing Data](https://docs.google.com/document/d/1IvK3LIFYqUcDb1YrBUFXvKZWmhdJl2m9Oa6LHDOPdcE/edit?usp=sharing) + +Spatial Transcriptomics + + From 160774d174bf713ad7e9876b5665de723aad47ec Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 23 Jan 2024 09:41:34 -0500 Subject: [PATCH 064/176] specific details updates (links added). --- data_pub_submission/specific_details.md | 1 + 1 file changed, 1 insertion(+) diff --git a/data_pub_submission/specific_details.md b/data_pub_submission/specific_details.md index f220f2f2..354f348f 100644 --- a/data_pub_submission/specific_details.md +++ b/data_pub_submission/specific_details.md @@ -8,6 +8,7 @@ Please see [Data Standards](https://data.humantumoratlas.org/standards) for an o !!! :warning: under development. Please see Sequencing Data and Accessory Files below for example google docs with specific submission details. +!!! [Accessory Files](https://docs.google.com/document/d/1pCzpf1s7Oh91V9tIwTovvrQfBWRnUJHqe1XBz3K8NfM/edit?usp=sharing) From 2aae64732e6c2236ebb03197f93079760b7532bb Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 23 Jan 2024 09:42:49 -0500 Subject: [PATCH 065/176] specific details updates (links added). --- data_pub_submission/specific_details.md | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/data_pub_submission/specific_details.md b/data_pub_submission/specific_details.md index 354f348f..345b043b 100644 --- a/data_pub_submission/specific_details.md +++ b/data_pub_submission/specific_details.md @@ -10,7 +10,7 @@ Please see [Data Standards](https://data.humantumoratlas.org/standards) for an o Please see Sequencing Data and Accessory Files below for example google docs with specific submission details. !!! -[Accessory Files](https://docs.google.com/document/d/1pCzpf1s7Oh91V9tIwTovvrQfBWRnUJHqe1XBz3K8NfM/edit?usp=sharing) +[Accessory Files](https://docs.google.com/document/d/1pCzpf1s7Oh91V9tIwTovvrQfBWRnUJHqe1XBz3K8NfM/edit?usp=sharing, target="_blank") Biospecimen @@ -20,7 +20,7 @@ Imaging RPPR -[Sequencing Data](https://docs.google.com/document/d/1IvK3LIFYqUcDb1YrBUFXvKZWmhdJl2m9Oa6LHDOPdcE/edit?usp=sharing) +[Sequencing Data](https://docs.google.com/document/d/1IvK3LIFYqUcDb1YrBUFXvKZWmhdJl2m9Oa6LHDOPdcE/edit?usp=sharing, target="_blank") Spatial Transcriptomics From 26b7753cc340d1e0daa7a3d27e0256a88d4f0625 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 23 Jan 2024 09:44:36 -0500 Subject: [PATCH 066/176] specific details updates (links added). --- data_pub_submission/specific_details.md | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/data_pub_submission/specific_details.md b/data_pub_submission/specific_details.md index 345b043b..7a5ae9d9 100644 --- a/data_pub_submission/specific_details.md +++ b/data_pub_submission/specific_details.md @@ -10,7 +10,7 @@ Please see [Data Standards](https://data.humantumoratlas.org/standards) for an o Please see Sequencing Data and Accessory Files below for example google docs with specific submission details. !!! -[Accessory Files](https://docs.google.com/document/d/1pCzpf1s7Oh91V9tIwTovvrQfBWRnUJHqe1XBz3K8NfM/edit?usp=sharing, target="_blank") +[Accessory Files](https://docs.google.com/document/d/1pCzpf1s7Oh91V9tIwTovvrQfBWRnUJHqe1XBz3K8NfM/edit?usp=sharing){target="_blank"} Biospecimen @@ -20,7 +20,7 @@ Imaging RPPR -[Sequencing Data](https://docs.google.com/document/d/1IvK3LIFYqUcDb1YrBUFXvKZWmhdJl2m9Oa6LHDOPdcE/edit?usp=sharing, target="_blank") +[Sequencing Data](https://docs.google.com/document/d/1IvK3LIFYqUcDb1YrBUFXvKZWmhdJl2m9Oa6LHDOPdcE/edit?usp=sharing){target="_blank"} Spatial Transcriptomics From 51f6e38359d25a34a8380d45be9847c66b10f4e2 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 23 Jan 2024 09:45:21 -0500 Subject: [PATCH 067/176] specific details updates (links added). --- data_pub_submission/specific_details.md | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/data_pub_submission/specific_details.md b/data_pub_submission/specific_details.md index 7a5ae9d9..def68ec0 100644 --- a/data_pub_submission/specific_details.md +++ b/data_pub_submission/specific_details.md @@ -10,7 +10,7 @@ Please see [Data Standards](https://data.humantumoratlas.org/standards) for an o Please see Sequencing Data and Accessory Files below for example google docs with specific submission details. !!! -[Accessory Files](https://docs.google.com/document/d/1pCzpf1s7Oh91V9tIwTovvrQfBWRnUJHqe1XBz3K8NfM/edit?usp=sharing){target="_blank"} +[Accessory Files](https://docs.google.com/document/d/1pCzpf1s7Oh91V9tIwTovvrQfBWRnUJHqe1XBz3K8NfM/edit?usp=sharing){:target="_blank"} Biospecimen @@ -20,7 +20,7 @@ Imaging RPPR -[Sequencing Data](https://docs.google.com/document/d/1IvK3LIFYqUcDb1YrBUFXvKZWmhdJl2m9Oa6LHDOPdcE/edit?usp=sharing){target="_blank"} +[Sequencing Data](https://docs.google.com/document/d/1IvK3LIFYqUcDb1YrBUFXvKZWmhdJl2m9Oa6LHDOPdcE/edit?usp=sharing){:target="_blank"} Spatial Transcriptomics From a004bb588cd3216d0247b914c01ee896259601c7 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 23 Jan 2024 09:45:49 -0500 Subject: [PATCH 068/176] specific details updates (links added). --- data_pub_submission/specific_details.md | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/data_pub_submission/specific_details.md b/data_pub_submission/specific_details.md index def68ec0..354f348f 100644 --- a/data_pub_submission/specific_details.md +++ b/data_pub_submission/specific_details.md @@ -10,7 +10,7 @@ Please see [Data Standards](https://data.humantumoratlas.org/standards) for an o Please see Sequencing Data and Accessory Files below for example google docs with specific submission details. !!! -[Accessory Files](https://docs.google.com/document/d/1pCzpf1s7Oh91V9tIwTovvrQfBWRnUJHqe1XBz3K8NfM/edit?usp=sharing){:target="_blank"} +[Accessory Files](https://docs.google.com/document/d/1pCzpf1s7Oh91V9tIwTovvrQfBWRnUJHqe1XBz3K8NfM/edit?usp=sharing) Biospecimen @@ -20,7 +20,7 @@ Imaging RPPR -[Sequencing Data](https://docs.google.com/document/d/1IvK3LIFYqUcDb1YrBUFXvKZWmhdJl2m9Oa6LHDOPdcE/edit?usp=sharing){:target="_blank"} +[Sequencing Data](https://docs.google.com/document/d/1IvK3LIFYqUcDb1YrBUFXvKZWmhdJl2m9Oa6LHDOPdcE/edit?usp=sharing) Spatial Transcriptomics From ec969bbe3af8132cf77815dc5f087b4866892b2b Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 23 Jan 2024 09:49:13 -0500 Subject: [PATCH 069/176] specific details updates (links added). --- data_pub_submission/specific_details.md | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/data_pub_submission/specific_details.md b/data_pub_submission/specific_details.md index 354f348f..d91d312c 100644 --- a/data_pub_submission/specific_details.md +++ b/data_pub_submission/specific_details.md @@ -10,7 +10,7 @@ Please see [Data Standards](https://data.humantumoratlas.org/standards) for an o Please see Sequencing Data and Accessory Files below for example google docs with specific submission details. !!! -[Accessory Files](https://docs.google.com/document/d/1pCzpf1s7Oh91V9tIwTovvrQfBWRnUJHqe1XBz3K8NfM/edit?usp=sharing) +[!ref Accessory Files](https://docs.google.com/document/d/1pCzpf1s7Oh91V9tIwTovvrQfBWRnUJHqe1XBz3K8NfM/edit?usp=sharing) Biospecimen @@ -20,7 +20,7 @@ Imaging RPPR -[Sequencing Data](https://docs.google.com/document/d/1IvK3LIFYqUcDb1YrBUFXvKZWmhdJl2m9Oa6LHDOPdcE/edit?usp=sharing) +[!ref Sequencing Data](https://docs.google.com/document/d/1IvK3LIFYqUcDb1YrBUFXvKZWmhdJl2m9Oa6LHDOPdcE/edit?usp=sharing) Spatial Transcriptomics From c6a18564c3ec17d8862edb5c74ca892450533fb3 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 23 Jan 2024 09:50:41 -0500 Subject: [PATCH 070/176] specific details updates (links added). --- data_pub_submission/specific_details.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data_pub_submission/specific_details.md b/data_pub_submission/specific_details.md index d91d312c..2e0a6e23 100644 --- a/data_pub_submission/specific_details.md +++ b/data_pub_submission/specific_details.md @@ -6,7 +6,7 @@ order: 995 Please see [Data Standards](https://data.humantumoratlas.org/standards) for an overview of HTAN Data Levels and Metadata Attributes for each data type. The following links provide specific submission details for each data type. -!!! :warning: under development. +!!! :construction: under development. Please see Sequencing Data and Accessory Files below for example google docs with specific submission details. !!! From 55d02fd4f7ce8d11c4e99d922720e07167fb8b82 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 23 Jan 2024 09:52:59 -0500 Subject: [PATCH 071/176] specific details updates (links added). --- data_pub_submission/specific_details.md | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/data_pub_submission/specific_details.md b/data_pub_submission/specific_details.md index 2e0a6e23..38664b66 100644 --- a/data_pub_submission/specific_details.md +++ b/data_pub_submission/specific_details.md @@ -10,7 +10,7 @@ Please see [Data Standards](https://data.humantumoratlas.org/standards) for an o Please see Sequencing Data and Accessory Files below for example google docs with specific submission details. !!! -[!ref Accessory Files](https://docs.google.com/document/d/1pCzpf1s7Oh91V9tIwTovvrQfBWRnUJHqe1XBz3K8NfM/edit?usp=sharing) +[!ref target="blank" text="Accessory Files"](https://docs.google.com/document/d/1pCzpf1s7Oh91V9tIwTovvrQfBWRnUJHqe1XBz3K8NfM/edit?usp=sharing) Biospecimen @@ -20,7 +20,7 @@ Imaging RPPR -[!ref Sequencing Data](https://docs.google.com/document/d/1IvK3LIFYqUcDb1YrBUFXvKZWmhdJl2m9Oa6LHDOPdcE/edit?usp=sharing) +[target="blank" text="Sequencing Data"](https://docs.google.com/document/d/1IvK3LIFYqUcDb1YrBUFXvKZWmhdJl2m9Oa6LHDOPdcE/edit?usp=sharing) Spatial Transcriptomics From 31d754df522709e671d2a78ba73cc34d065c53d4 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 23 Jan 2024 09:53:51 -0500 Subject: [PATCH 072/176] specific details updates (links added). --- data_pub_submission/specific_details.md | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/data_pub_submission/specific_details.md b/data_pub_submission/specific_details.md index 38664b66..cd0e1006 100644 --- a/data_pub_submission/specific_details.md +++ b/data_pub_submission/specific_details.md @@ -6,8 +6,8 @@ order: 995 Please see [Data Standards](https://data.humantumoratlas.org/standards) for an overview of HTAN Data Levels and Metadata Attributes for each data type. The following links provide specific submission details for each data type. -!!! :construction: under development. -Please see Sequencing Data and Accessory Files below for example google docs with specific submission details. +!!! under development. +:construction: Please see Sequencing Data and Accessory Files below for example google docs with specific submission details. !!! [!ref target="blank" text="Accessory Files"](https://docs.google.com/document/d/1pCzpf1s7Oh91V9tIwTovvrQfBWRnUJHqe1XBz3K8NfM/edit?usp=sharing) From aee9658155907518b90efc0909dd3078312454b4 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 23 Jan 2024 09:54:43 -0500 Subject: [PATCH 073/176] specific details updates (links added). --- data_pub_submission/specific_details.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data_pub_submission/specific_details.md b/data_pub_submission/specific_details.md index cd0e1006..ea6a6413 100644 --- a/data_pub_submission/specific_details.md +++ b/data_pub_submission/specific_details.md @@ -20,7 +20,7 @@ Imaging RPPR -[target="blank" text="Sequencing Data"](https://docs.google.com/document/d/1IvK3LIFYqUcDb1YrBUFXvKZWmhdJl2m9Oa6LHDOPdcE/edit?usp=sharing) +[!ref target="blank" text="Sequencing Data"](https://docs.google.com/document/d/1IvK3LIFYqUcDb1YrBUFXvKZWmhdJl2m9Oa6LHDOPdcE/edit?usp=sharing) Spatial Transcriptomics From 03c4b30c75cb06332c2b1bd117962e8899522d11 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 23 Jan 2024 10:02:09 -0500 Subject: [PATCH 074/176] specific details updates (links added). --- data_pub_submission/specific_details.md | 2 ++ 1 file changed, 2 insertions(+) diff --git a/data_pub_submission/specific_details.md b/data_pub_submission/specific_details.md index ea6a6413..0dfc12ac 100644 --- a/data_pub_submission/specific_details.md +++ b/data_pub_submission/specific_details.md @@ -8,6 +8,8 @@ Please see [Data Standards](https://data.humantumoratlas.org/standards) for an o !!! under development. :construction: Please see Sequencing Data and Accessory Files below for example google docs with specific submission details. + +:eyes: Note this page demonstrates a different way to embed links where the url is included and links open in a separate tab. !!! [!ref target="blank" text="Accessory Files"](https://docs.google.com/document/d/1pCzpf1s7Oh91V9tIwTovvrQfBWRnUJHqe1XBz3K8NfM/edit?usp=sharing) From 94e9d7ec59813d2975456087bf51d3c0a6050d80 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 23 Jan 2024 10:06:34 -0500 Subject: [PATCH 075/176] marking missing 3rd update on main readme. --- readme.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/readme.md b/readme.md index 3f5cc6c0..c839ed75 100644 --- a/readme.md +++ b/readme.md @@ -12,7 +12,7 @@ The manual can be found at https://docs.humantumoratlas.org/. | Date | Comment | |------------|--------------------------| -| | Third version of manual | +| :exclamation::exclamation: | Third version of manual | | 2023-06-01 | Second version of manual | | 2022-09-28 | First version of manual | From 4af3537a2e52f7aee378d86e47a8d6348fc36b64 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 23 Jan 2024 10:12:15 -0500 Subject: [PATCH 076/176] warnign re: centers table needs update --- overview/centers.md | 4 ++++ 1 file changed, 4 insertions(+) diff --git a/overview/centers.md b/overview/centers.md index 601948eb..48dbc606 100644 --- a/overview/centers.md +++ b/overview/centers.md @@ -6,6 +6,10 @@ order: 999 The HTAN Network consists of ten research centers, and two pilot projects. We also run multiple trans-network projects, referred to as TNPs. Each research center or TNP Project is identified with a unique HTAN prefix. +!!! Need to update table to include additional TNPs; Eventually need to update with new centers +:exclamation::exclamation: +!!! + | Prefix | Contact Institution or Project Name | Atlas Type | Area of Focus | | ------ | --------------------------------------- | ---------------- | --------------------------------- | | HTA1 | Human Tumor Atlas Pilot Project (HTAPP) | Tumor Atlas | Pilot Project | From b6cbdfc46c0ccda98ed468f7109ba2b30e54d23a Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 23 Jan 2024 10:16:18 -0500 Subject: [PATCH 077/176] added changes summary to main readme. --- readme.md | 10 +++++----- 1 file changed, 5 insertions(+), 5 deletions(-) diff --git a/readme.md b/readme.md index c839ed75..c6f9fdd6 100644 --- a/readme.md +++ b/readme.md @@ -10,9 +10,9 @@ The manual can be found at https://docs.humantumoratlas.org/. ## Content Updates -| Date | Comment | -|------------|--------------------------| -| :exclamation::exclamation: | Third version of manual | -| 2023-06-01 | Second version of manual | -| 2022-09-28 | First version of manual | +| Date | Comment | Changes summary | +|------------|--------------------------|-----------------| +| :exclamation::exclamation: | Third version of manual | Simplified Data Model section, added Data Submission and Additional Info Sections | +| 2023-06-01 | Second version of manual | | +| 2022-09-28 | First version of manual | | From 1d2805988a27963472fa0101e98da055cae56e3e Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 23 Jan 2024 10:17:24 -0500 Subject: [PATCH 078/176] added changes summary to main readme. --- readme.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/readme.md b/readme.md index c6f9fdd6..d23a8bb2 100644 --- a/readme.md +++ b/readme.md @@ -12,7 +12,7 @@ The manual can be found at https://docs.humantumoratlas.org/. | Date | Comment | Changes summary | |------------|--------------------------|-----------------| -| :exclamation::exclamation: | Third version of manual | Simplified Data Model section, added Data Submission and Additional Info Sections | +| :exclamation::exclamation: | Third version of manual | Simplified Data Model section: added "Data Publication Submissions" and "Additional Information" Sections | | 2023-06-01 | Second version of manual | | | 2022-09-28 | First version of manual | | From 2c7ecd2b587b636a925357474a7651516a6375b7 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 23 Jan 2024 10:18:11 -0500 Subject: [PATCH 079/176] minor punctuation chg. --- readme.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/readme.md b/readme.md index d23a8bb2..92c2d2c9 100644 --- a/readme.md +++ b/readme.md @@ -12,7 +12,7 @@ The manual can be found at https://docs.humantumoratlas.org/. | Date | Comment | Changes summary | |------------|--------------------------|-----------------| -| :exclamation::exclamation: | Third version of manual | Simplified Data Model section: added "Data Publication Submissions" and "Additional Information" Sections | +| :exclamation::exclamation: | Third version of manual | Simplified Data Model section; added "Data Publication Submissions" and "Additional Information" Sections | | 2023-06-01 | Second version of manual | | | 2022-09-28 | First version of manual | | From 196b7ebab1ebc2b2d0efc5fb20d45e3fc03611ae Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 23 Jan 2024 10:19:02 -0500 Subject: [PATCH 080/176] Minor edits main readme. --- readme.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/readme.md b/readme.md index 92c2d2c9..9a6b681d 100644 --- a/readme.md +++ b/readme.md @@ -13,6 +13,6 @@ The manual can be found at https://docs.humantumoratlas.org/. | Date | Comment | Changes summary | |------------|--------------------------|-----------------| | :exclamation::exclamation: | Third version of manual | Simplified Data Model section; added "Data Publication Submissions" and "Additional Information" Sections | -| 2023-06-01 | Second version of manual | | +| 2023-06-01 | Second version of manual | Content Updates | | 2022-09-28 | First version of manual | | From 5f47f76d0efbdcf8e54b1915a6fb22b13fea9384 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 23 Jan 2024 10:22:16 -0500 Subject: [PATCH 081/176] Minor edits main readme. --- readme.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/readme.md b/readme.md index 9a6b681d..9018c210 100644 --- a/readme.md +++ b/readme.md @@ -13,6 +13,6 @@ The manual can be found at https://docs.humantumoratlas.org/. | Date | Comment | Changes summary | |------------|--------------------------|-----------------| | :exclamation::exclamation: | Third version of manual | Simplified Data Model section; added "Data Publication Submissions" and "Additional Information" Sections | -| 2023-06-01 | Second version of manual | Content Updates | +| 2023-06-01 | Second version of manual | | | 2022-09-28 | First version of manual | | From 7e464acf14e2b0042d87d81724c6c23518372f63 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Thu, 1 Feb 2024 09:56:19 -0500 Subject: [PATCH 082/176] adding suggested chgs to open access intro. --- open_access/introduction.md | 6 +++++- 1 file changed, 5 insertions(+), 1 deletion(-) diff --git a/open_access/introduction.md b/open_access/introduction.md index 2e4b944b..78160f4d 100644 --- a/open_access/introduction.md +++ b/open_access/introduction.md @@ -7,5 +7,9 @@ order: 1000 Open access HTAN data is available via: - The HTAN Data Portal -- NCI Image Data Commons (IDC) +- NCI Image Data Commons (IDC) :exclamation: change this to CDC? - Google BigQuery +:exclamation: add CellxGene? + +!!! Would add a brief overview of when to go where. eg. access x in Data Portal....if you want to XXX go to CellxGene....if you want to XXX go to BigQuery...etc +!!! From 0a7fb2f55ee039a7547a50e7140242b752b58453 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 2 Feb 2024 11:33:50 -0500 Subject: [PATCH 083/176] changing info for new centers -- remove accessing data from para 2. --- data_pub_submission/Information_New_Centers.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data_pub_submission/Information_New_Centers.md b/data_pub_submission/Information_New_Centers.md index 9f4629fb..6f7c6d9d 100644 --- a/data_pub_submission/Information_New_Centers.md +++ b/data_pub_submission/Information_New_Centers.md @@ -8,7 +8,7 @@ Welcome to the HTAN Network! Documents provided on the HTAN [resources page](https://humantumoratlas.org/resources) detail requirements for publications, data sharing and data use. -All HTAN members must have an executed Human Tumor Atlas Network DMSA (Internal Data and Materials Sharing Agreement) [(HTAN DMSA)](https://docs.google.com/document/d/1RPFm9MBJv8DjZmYZyIv0jbjtNJ8fnwGjYDjlK4lL4nc/edit) with Sage Bionetworks prior to contributing or accessing data in the HTAN DCC. To initiate execution of the HTAN DMSA, contact Sage HTAN Governance (htan@sagebionetworks.jira.com). Please include the name and contact information of your HTAN PI and Institution Signatory to enable routing the HTAN DMSA for execution. +All HTAN members must have an executed Human Tumor Atlas Network DMSA (Internal Data and Materials Sharing Agreement) [(HTAN DMSA)](https://docs.google.com/document/d/1RPFm9MBJv8DjZmYZyIv0jbjtNJ8fnwGjYDjlK4lL4nc/edit) with Sage Bionetworks prior to contributing data to the HTAN DCC. To initiate execution of the HTAN DMSA, contact Sage HTAN Governance (htan@sagebionetworks.jira.com). Please include the name and contact information of your HTAN PI and Institution Signatory to enable routing the HTAN DMSA for execution. HTAN Centers are assigned a [data liaison](../data_pub_submission/Data_Liaisons.md) from the HTAN Data Coordinating Center [(DCC)](https://humantumoratlas.org/htan-dcc). Trans-Network Projects (TNPs) are also assigned liaisons. Your liaison will help guide you through setting up a new atlas or project, creating HTAN identifiers, filling out metadata sheets, and submitting data. Please keep your liaison informed of publications timelines and new data submissions. From 0f7360279b1c51a1e49b73888082fe3ed89344e8 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 2 Feb 2024 11:36:36 -0500 Subject: [PATCH 084/176] change to data sub overview, 'assay data files' --- data_pub_submission/overview.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data_pub_submission/overview.md b/data_pub_submission/overview.md index d42521ab..2fffcac1 100644 --- a/data_pub_submission/overview.md +++ b/data_pub_submission/overview.md @@ -8,7 +8,7 @@ Only HTAN Centers and Associate Members can submit data to the HTAN Network's re :exclamation: *Prior to submitting data, all data must be de-identified. Please see [Data Deidentification](../data_pub_submission/Data_Deidentification.md) for more information.* Data Submission involves two key steps: -1. Uploading data files to Synapse; and +1. Uploading assay data files to Synapse; and 2. Completing and validating manifests using the Data Curator App (DCA). HTAN-associated publications are also submitted by completing and validating a manifest using the DCA. From fa3cc7f45bf515a04d854c4cf2d0c88238c6f445 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 2 Feb 2024 11:44:40 -0500 Subject: [PATCH 085/176] change to data de-id -- NIH confid statement. --- data_pub_submission/Data_Deidentification.md | 4 +++- 1 file changed, 3 insertions(+), 1 deletion(-) diff --git a/data_pub_submission/Data_Deidentification.md b/data_pub_submission/Data_Deidentification.md index dc0a89af..49ee7e36 100644 --- a/data_pub_submission/Data_Deidentification.md +++ b/data_pub_submission/Data_Deidentification.md @@ -17,7 +17,9 @@ By signing the HTAN DMSA, HTAN members’ institutional signing officials and PI - all data are consistent with applicable U.S. laws, regulations, and its institutional policies; and -- that an IRB/Privacy Board or equivalent body has assured that submission and subsequent sharing of data are consistent with the Informed Consent of the Data Subject(s) from whom the data were obtained. In addition, the data will be protected by the NIH Certificate of Confidentiality. +- that an IRB/Privacy Board or equivalent body has assured that submission and subsequent sharing of data are consistent with the Informed Consent of the Data Subject(s) from whom the data were obtained. + +In addition, the data are protected by an NIH Certificate of Confidentiality. Prior to transferring data to the HTAN DCC, members are responsible for fully de-identifying the data being transferred. Full de-identification of data includes confirmation that data file names do not contain any information that could be used to re-identify that data subject. From a4cb77b42eb28ea6496247b18a1f08d793b433af Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 2 Feb 2024 12:05:04 -0500 Subject: [PATCH 086/176] Suggested changes to clin, bio, assay submission from Alex. --- data_pub_submission/clin_biospec_assay.md | 25 +++++++++-------------- 1 file changed, 10 insertions(+), 15 deletions(-) diff --git a/data_pub_submission/clin_biospec_assay.md b/data_pub_submission/clin_biospec_assay.md index ea4e0295..2494a429 100644 --- a/data_pub_submission/clin_biospec_assay.md +++ b/data_pub_submission/clin_biospec_assay.md @@ -5,7 +5,7 @@ order: 996 # Submitting Clinical, Biospecimen or Assay Data As stated in [Data and Publication Submission Overview](../data_pub_submission/overview.md), data submission involves two key steps: -1. Uploading data files to Synapse; and +1. Uploading assay data files to Synapse; and 2. Completing and validating manifests using the Data Curator App (DCA). This page provides more details regarding those steps. However, you will also need to understand the HTAN data model and specific requirements for your particular data type. For a general overview of the HTAN data model, please see [HTAN Data Model](../data_model.md). To understand specific requirements for your data type, please see [Data Standards](https://humantumoratlas.org/standards). @@ -15,14 +15,13 @@ HTAN uses the Synapse [Web Portal](https:/www.synapse.org) and [DCA](https://dca 1. [Have at least one user with Certified User status on Synapse.](#have-at-least-one-user-with-certified-user-status-on-synapse) 2. [Contact your Data Liaison to set up your project and cloud bucket.](#contact-your-data-liaison-to-set-up-your-project-and-cloud-bucket) 3. [Ensure the assay dataset conforms to the HTAN Data Model, uses HTAN Identifiers and does not contain Protected Health Information (PHI).](#ensure-the-dataset-conforms-to-the-htan-data-model-uses-htan-identifiers-and-does-not-contain-phi) -4. [Organize the data.](#organize-the-data) -5. [Upload your dataset to Synapse.](#upload-your-dataset-to-the-synapse-project) -6. [Validate and submit metadata using the DCA.](#validate-and-submit-metadata-using-synapses-data-curator-app-dca) +4. [Organize and upload your dataset to the Synapse Project](#organize-and-upload-your-dataset-to-the-synapse-project) +5. [Validate and submit metadata using the DCA.](#validate-and-submit-metadata-using-synapses-data-curator-app-dca) Please read the rest of this page for more information about each of these steps. ## Have at least one user with Certified User status on Synapse. -To upload files to Synapse, you need to be a [certified user](https://help.synapse.org/docs/Synapse-User-Account-Types.2007072795.html). Because Synapse stores data from human subjects research, Sage Bionetworks requires that you demonstrate understanding of and compliance with privacy and security issues. You can complete your certification by taking a short certification quiz. Please see the Synapse [certified user documentation](https://help.synapse.org/docs/Synapse-User-Account-Types.2007072795.html) for more inforamtion. +To upload files to Synapse, you need to be a [certified user](https://help.synapse.org/docs/Synapse-User-Account-Types.2007072795.html). Because Synapse stores data from human subjects research, Sage Bionetworks requires that you demonstrate understanding of and compliance with privacy and security issues. You can complete your certification by taking a short certification quiz. Please see the Synapse [certified user documentation](https://help.synapse.org/docs/Synapse-User-Account-Types.2007072795.html) for more information. ## Contact your Data Liaison to set up your project and cloud bucket. @@ -41,25 +40,21 @@ The HTAN Data Model is built upon data standards described on the [Data Standard A concrete way to understand the expectations for data submissions is to view the metadata templates for clinical, biospecimen and assay data available in Synapse's Data Curator App ([DCA](https://dca.app.sagebionetworks.org/)). For any given dataset, you may be submitting: -- clinical data metadata template(s) -- biospecimen metadata template(s) -- assay metadata template(s) +- clinical manifest(s), e.g. Demographics, Diagnosis +- biospecimen manifest(s) +- assay manifest(s), e.g. Bulk RNA-seq level 1 - assay data files The first three items will be validated and submitted using the Data Curator App. The last item, assay data files, only needs to be uploaded to the synapse project itself. -All data should be identified using HTAN identifiers. Please see the [HTAN Identifier SOP](https://docs.google.com/document/d/1podtPP8L1UNvVxx9_c_szlDcU1f8n7bige6XA_GoRVM/edit?usp=sharing) for detailed instructions regarding assigning HTAN Identifiers. +All data should be identified using HTAN identifiers. Please see the [HTAN Identifier](../data_model/identifiers.md) section of this manual for more information regarding HTAN identifiers. !!! *Please review your data to ensure that it does not contain PHI.* !!! -## Organize the data +## Organize and upload your dataset to the Synapse Project -Please organize your data in the following manner. - -:exclamation: :exclamation: Need more information here. (does HTAN use the flattened or hierarchy format?) - -## Upload your dataset to the Synapse Project. +Please organize your data using the flattened data layout described in Synapse's [Data Ingress Docs](https://dca-docs.scrollhelp.site/DCA/Working-version/HTAN/organize-your-data-upload#OrganizeyourDataUpload-FlattenedDataLayoutExample) Data files can be transferred using the Synapse User Interface (Synapse UI) or programmatically. Please see Synapse's [Data Ingress Docs](https://dca-docs.scrollhelp.site/DCA/Working-version/HTAN/uploading-data) for more information on how to upload files. From 72e145236ccde305c3240356354463064adc44b8 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 2 Feb 2024 15:04:19 -0500 Subject: [PATCH 087/176] updates to data liaisons (clarisse) --- data_pub_submission/Data_Liaisons.md | 7 ++++--- 1 file changed, 4 insertions(+), 3 deletions(-) diff --git a/data_pub_submission/Data_Liaisons.md b/data_pub_submission/Data_Liaisons.md index a7ed41d8..c3b99900 100644 --- a/data_pub_submission/Data_Liaisons.md +++ b/data_pub_submission/Data_Liaisons.md @@ -20,11 +20,12 @@ Here is the current list of centers, their atlases and DCC liaisons: | HTAN MSK | HTA8 | Ino de Bruijn | ebruiji@mskcc.org | | HTAN OHSU | HTA9 | Adam Taylor | adam.taylor@sagebase.org | | HTAN Stanford | HTA10 | Adam Taylor | adam.taylor@sagebase.org | -| HTAN Vanderbilt | HTA11 | Vesteinn Thorsson | thorsson@isbscience.org | -| HTAN WUSTL | HTA12 | Vesteinn Thorsson | thorsson@isbscience.org | +| HTAN Vanderbilt | HTA11 | Clarisse Lau | clau@systemsbiology.org | +| HTAN WUSTL | HTA12 | Clarisse Lau | clau@systemsbiology.org | | TNP SARDANA | HTA13 | Dave Gibbs | dgibbs@systemsbiology.org | | TNP TMA | HTA14 | Dave Gibbs | dgibbs@systemsbiology.org | -| TNP SRRS | HTA15 | Jennifer Altreuter | jennifer@ds.dfci.harvard.edu | +| TNP SRRS | HTA15 | Clarisse Lau | clau@systemsbiology.org | + | Jennifer Altreuter | jennifer@ds.dfci.harvard.edu | | TNP CASI | HTA16 | Jennifer Altreuter | jennifer@ds.dfci.harvard.edu | From d68365a9130a452d261af9e81bd24ed735a8c1a8 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 2 Feb 2024 15:05:32 -0500 Subject: [PATCH 088/176] updates to data liaisons (clarisse) --- data_pub_submission/Data_Liaisons.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data_pub_submission/Data_Liaisons.md b/data_pub_submission/Data_Liaisons.md index c3b99900..704832b1 100644 --- a/data_pub_submission/Data_Liaisons.md +++ b/data_pub_submission/Data_Liaisons.md @@ -25,7 +25,7 @@ Here is the current list of centers, their atlases and DCC liaisons: | TNP SARDANA | HTA13 | Dave Gibbs | dgibbs@systemsbiology.org | | TNP TMA | HTA14 | Dave Gibbs | dgibbs@systemsbiology.org | | TNP SRRS | HTA15 | Clarisse Lau | clau@systemsbiology.org | - | Jennifer Altreuter | jennifer@ds.dfci.harvard.edu | +|| | Jennifer Altreuter (snTNP) | jennifer@ds.dfci.harvard.edu | | TNP CASI | HTA16 | Jennifer Altreuter | jennifer@ds.dfci.harvard.edu | From 1b9123a9d559bc3218086293d05528bea07a1760 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 2 Feb 2024 15:07:51 -0500 Subject: [PATCH 089/176] updates to data liaisons (clarisse) --- data_pub_submission/Data_Liaisons.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data_pub_submission/Data_Liaisons.md b/data_pub_submission/Data_Liaisons.md index 704832b1..ceba9db0 100644 --- a/data_pub_submission/Data_Liaisons.md +++ b/data_pub_submission/Data_Liaisons.md @@ -25,7 +25,7 @@ Here is the current list of centers, their atlases and DCC liaisons: | TNP SARDANA | HTA13 | Dave Gibbs | dgibbs@systemsbiology.org | | TNP TMA | HTA14 | Dave Gibbs | dgibbs@systemsbiology.org | | TNP SRRS | HTA15 | Clarisse Lau | clau@systemsbiology.org | -|| | Jennifer Altreuter (snTNP) | jennifer@ds.dfci.harvard.edu | +|| | Jennifer Altreuter (snRNAseq) | jennifer@ds.dfci.harvard.edu | | TNP CASI | HTA16 | Jennifer Altreuter | jennifer@ds.dfci.harvard.edu | From 4d35d533f300cc1f9c869be3658ccf9e968bf879 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 2 Feb 2024 15:08:36 -0500 Subject: [PATCH 090/176] updates to data liaisons (clarisse) --- data_pub_submission/Data_Liaisons.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data_pub_submission/Data_Liaisons.md b/data_pub_submission/Data_Liaisons.md index ceba9db0..c985713a 100644 --- a/data_pub_submission/Data_Liaisons.md +++ b/data_pub_submission/Data_Liaisons.md @@ -25,7 +25,7 @@ Here is the current list of centers, their atlases and DCC liaisons: | TNP SARDANA | HTA13 | Dave Gibbs | dgibbs@systemsbiology.org | | TNP TMA | HTA14 | Dave Gibbs | dgibbs@systemsbiology.org | | TNP SRRS | HTA15 | Clarisse Lau | clau@systemsbiology.org | -|| | Jennifer Altreuter (snRNAseq) | jennifer@ds.dfci.harvard.edu | +|| HTA15 | Jennifer Altreuter (snRNAseq) | jennifer@ds.dfci.harvard.edu | | TNP CASI | HTA16 | Jennifer Altreuter | jennifer@ds.dfci.harvard.edu | From e41623fefb52d0d6050b7ec5116a12c9c4340380 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 2 Feb 2024 15:13:10 -0500 Subject: [PATCH 091/176] . --- data_pub_submission/Data_Liaisons.md | 5 +---- 1 file changed, 1 insertion(+), 4 deletions(-) diff --git a/data_pub_submission/Data_Liaisons.md b/data_pub_submission/Data_Liaisons.md index c985713a..368ca65a 100644 --- a/data_pub_submission/Data_Liaisons.md +++ b/data_pub_submission/Data_Liaisons.md @@ -26,7 +26,4 @@ Here is the current list of centers, their atlases and DCC liaisons: | TNP TMA | HTA14 | Dave Gibbs | dgibbs@systemsbiology.org | | TNP SRRS | HTA15 | Clarisse Lau | clau@systemsbiology.org | || HTA15 | Jennifer Altreuter (snRNAseq) | jennifer@ds.dfci.harvard.edu | -| TNP CASI | HTA16 | Jennifer Altreuter | jennifer@ds.dfci.harvard.edu | - - - +| TNP CASI | HTA16 | Jennifer Altreuter | jennifer@ds.dfci.harvard.edu | \ No newline at end of file From d821196a3a2b0f3991da0441759088898eaeeb89 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 2 Feb 2024 15:24:27 -0500 Subject: [PATCH 092/176] adding information regarding identifier special situations e.g. '0000' and 'ext' --- data_model/identifiers.md | 18 +++++++++++++++++- 1 file changed, 17 insertions(+), 1 deletion(-) diff --git a/data_model/identifiers.md b/data_model/identifiers.md index 3f93d79c..a7356d71 100644 --- a/data_model/identifiers.md +++ b/data_model/identifiers.md @@ -24,7 +24,7 @@ Derivative data includes anything derived from a research participant, including ::= _integer ``` -For example, if research participant 1 within the CHOP project (HTA4) shas provided three samples, you would have three HTAN IDs, such as: +For example, if research participant 1 within the CHOP project (HTA4) has provided three samples, you would have three HTAN IDs, such as: ``` HTA4_1_1 @@ -38,6 +38,22 @@ If a single data file is generated from one of those samples, that file could ha HTA4_1_42 ``` +If a single data file is derived from more than one participant, the file identifier may contain a wildcard string e.g. ‘0000’, after the HTAN center identifier. For example: + +``` +HTA4_0000_1 +HTA4_0000_2 +HTA4_0000_3 +``` + +If a data file is derived from an external control participant, the biospecimen and file identifiers will contain the string ‘EXT’ before the external control participant integer. For example: + +``` +HTA4_EXT1_1 +HTA4_EXT2_2 +HTA4_EXT3_3 +``` + More detailed information about HTAN Identifiers may be found in the [HTAN Identifiers SOP](https://docs.google.com/document/d/1podtPP8L1UNvVxx9_c_szlDcU1f8n7bige6XA_GoRVM/edit#heading=h.768a6pngjha3). Note that the explicit linking of participants to biospecimens to assays is not encoded in the HTAN Identifier. Rather, the linking is encoded in explicit metadata elements (see [Relationship Model](relationships.md)). From af8d46d143cf5b9366462399b142e6a3bab3bc73 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 2 Feb 2024 15:59:39 -0500 Subject: [PATCH 093/176] updated to open access intro. --- open_access/introduction.md | 12 +++++++----- 1 file changed, 7 insertions(+), 5 deletions(-) diff --git a/open_access/introduction.md b/open_access/introduction.md index 78160f4d..0c9fa3b8 100644 --- a/open_access/introduction.md +++ b/open_access/introduction.md @@ -4,12 +4,14 @@ order: 1000 # Open Access Data -Open access HTAN data is available via: +Open access HTAN data is available via the following services: + +- The HTAN Data Portal +- CellxGene +- The NCI Image Data Commons [(IDC)](https://portal.imaging.datacommons.cancer.gov/) +- Institute for Systems Biology Cancer Gateway in the Cloud [(ISB-CGC)](https://isb-cgc.appspot.com/) Google BigQuery + -- The HTAN Data Portal -- NCI Image Data Commons (IDC) :exclamation: change this to CDC? -- Google BigQuery -:exclamation: add CellxGene? !!! Would add a brief overview of when to go where. eg. access x in Data Portal....if you want to XXX go to CellxGene....if you want to XXX go to BigQuery...etc !!! From 10b289160a54e0572bcdc3c491d3cbb38adb8aa1 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 2 Feb 2024 16:37:27 -0500 Subject: [PATCH 094/176] Open Data Access Intro updates. --- open_access/introduction.md | 23 +++++++++++++++++------ 1 file changed, 17 insertions(+), 6 deletions(-) diff --git a/open_access/introduction.md b/open_access/introduction.md index 0c9fa3b8..b5c3fdf0 100644 --- a/open_access/introduction.md +++ b/open_access/introduction.md @@ -4,14 +4,25 @@ order: 1000 # Open Access Data -Open access HTAN data is available via the following services: +Open access HTAN data is available via the following services and tools: -- The HTAN Data Portal -- CellxGene +- The [HTAN Data Portal](https://data.humantumoratlas.org/explore) +- [Synapse](synapse.org) :exclamation: data portal has "Synapse" as data access -- where is the data for public users of synapse? +- [CellxGene](https://cellxgene.cziscience.com/) - The NCI Image Data Commons [(IDC)](https://portal.imaging.datacommons.cancer.gov/) -- Institute for Systems Biology Cancer Gateway in the Cloud [(ISB-CGC)](https://isb-cgc.appspot.com/) Google BigQuery +- Seven Bridges-Cancer Genomic Cloud [(SB-CGC)](https://cgc-accounts.sbgenomics.com/) +- Google BigQuery via the Institute for Systems Biology Cancer Gateway in the Cloud [(ISB-CGC)](https://isb-cgc.appspot.com/) +- [cBioPortal](https://www.cbioportal.org/) +The HTAN Data Portal provides an overview of all publicly released data and links to: +- CellxGene for visualization of single cell RNA-sequencing data +- Minerva rendered images and stories. +- Google BigQuery tables. +- cBioPortal +Open Access Images can be downloaded from SB-CGC. -!!! Would add a brief overview of when to go where. eg. access x in Data Portal....if you want to XXX go to CellxGene....if you want to XXX go to BigQuery...etc -!!! +Google BigQuery Access provides direct access to a subset of assay data (mainly level 4 files) on a cloud platform. The Google BigQuery tables provide an easy way to build cohorts using spcific data fields. + +!!! For more detailed information about the HTAN Portal, CellxGene, Visualizing Images, Accessing Images and/or Using Google BigQuery, please see the next sections of this manual. +!!! \ No newline at end of file From d228ef60790aede7d63f3211912585fa05a97e3f Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 2 Feb 2024 16:41:22 -0500 Subject: [PATCH 095/176] Open Data Access Intro updates. --- open_access/introduction.md | 14 +++++++------- 1 file changed, 7 insertions(+), 7 deletions(-) diff --git a/open_access/introduction.md b/open_access/introduction.md index b5c3fdf0..6c576232 100644 --- a/open_access/introduction.md +++ b/open_access/introduction.md @@ -6,13 +6,13 @@ order: 1000 Open access HTAN data is available via the following services and tools: -- The [HTAN Data Portal](https://data.humantumoratlas.org/explore) -- [Synapse](synapse.org) :exclamation: data portal has "Synapse" as data access -- where is the data for public users of synapse? -- [CellxGene](https://cellxgene.cziscience.com/) -- The NCI Image Data Commons [(IDC)](https://portal.imaging.datacommons.cancer.gov/) -- Seven Bridges-Cancer Genomic Cloud [(SB-CGC)](https://cgc-accounts.sbgenomics.com/) -- Google BigQuery via the Institute for Systems Biology Cancer Gateway in the Cloud [(ISB-CGC)](https://isb-cgc.appspot.com/) -- [cBioPortal](https://www.cbioportal.org/) +[!ref target="blank" text="HTAN Data Portal"](https://data.humantumoratlas.org/explore) +[!ref target="blank" text="Synapse"](https://synapse.org) :exclamation: data portal has "Synapse" as data access -- where is the data for public users of synapse? +[!ref target="blank" text="CellxGene"](https://cellxgene.cziscience.com/) +[!ref target="blank" text="The NCI Image Data Commons (IDC)"](https://portal.imaging.datacommons.cancer.gov/) +[!ref target="blank" text="Seven Bridges-Cancer Genomic Cloud (SB-CGC)"](https://cgc-accounts.sbgenomics.com/) +[!ref target="blank" text="Google BigQuery via the Institute for Systems Biology Cancer Gateway in the Cloud (ISB-CGC)"](https://isb-cgc.appspot.com/) +[!ref target="blank" text="cBioPortal"](https://www.cbioportal.org/) The HTAN Data Portal provides an overview of all publicly released data and links to: - CellxGene for visualization of single cell RNA-sequencing data From 5e6a4c9ddc36818bd35391b7f3dba8f693e6c33a Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 2 Feb 2024 16:42:15 -0500 Subject: [PATCH 096/176] Open Data Access Intro updates. --- open_access/introduction.md | 6 ++++++ 1 file changed, 6 insertions(+) diff --git a/open_access/introduction.md b/open_access/introduction.md index 6c576232..539f5622 100644 --- a/open_access/introduction.md +++ b/open_access/introduction.md @@ -7,11 +7,17 @@ order: 1000 Open access HTAN data is available via the following services and tools: [!ref target="blank" text="HTAN Data Portal"](https://data.humantumoratlas.org/explore) + [!ref target="blank" text="Synapse"](https://synapse.org) :exclamation: data portal has "Synapse" as data access -- where is the data for public users of synapse? + [!ref target="blank" text="CellxGene"](https://cellxgene.cziscience.com/) + [!ref target="blank" text="The NCI Image Data Commons (IDC)"](https://portal.imaging.datacommons.cancer.gov/) + [!ref target="blank" text="Seven Bridges-Cancer Genomic Cloud (SB-CGC)"](https://cgc-accounts.sbgenomics.com/) + [!ref target="blank" text="Google BigQuery via the Institute for Systems Biology Cancer Gateway in the Cloud (ISB-CGC)"](https://isb-cgc.appspot.com/) + [!ref target="blank" text="cBioPortal"](https://www.cbioportal.org/) The HTAN Data Portal provides an overview of all publicly released data and links to: From f358b723653b1418c8b7079abfaf5c1a06bcd8e0 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 2 Feb 2024 16:43:12 -0500 Subject: [PATCH 097/176] Open Data Access Intro updates. --- open_access/introduction.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/open_access/introduction.md b/open_access/introduction.md index 539f5622..4d7e89ac 100644 --- a/open_access/introduction.md +++ b/open_access/introduction.md @@ -16,7 +16,7 @@ Open access HTAN data is available via the following services and tools: [!ref target="blank" text="Seven Bridges-Cancer Genomic Cloud (SB-CGC)"](https://cgc-accounts.sbgenomics.com/) -[!ref target="blank" text="Google BigQuery via the Institute for Systems Biology Cancer Gateway in the Cloud (ISB-CGC)"](https://isb-cgc.appspot.com/) +[!ref target="blank" text="Google BigQuery"](https://isb-cgc.appspot.com/) [!ref target="blank" text="cBioPortal"](https://www.cbioportal.org/) From cb0223c1753b6eff1bca233de06576e728c35565 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 2 Feb 2024 16:43:40 -0500 Subject: [PATCH 098/176] Open Data Access Intro updates. --- open_access/introduction.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/open_access/introduction.md b/open_access/introduction.md index 4d7e89ac..80fe4974 100644 --- a/open_access/introduction.md +++ b/open_access/introduction.md @@ -8,7 +8,7 @@ Open access HTAN data is available via the following services and tools: [!ref target="blank" text="HTAN Data Portal"](https://data.humantumoratlas.org/explore) -[!ref target="blank" text="Synapse"](https://synapse.org) :exclamation: data portal has "Synapse" as data access -- where is the data for public users of synapse? +[!ref target="blank" text="Synapse?"](https://synapse.org) :exclamation: data portal has "Synapse" as data access -- where is the data for public users of synapse? [!ref target="blank" text="CellxGene"](https://cellxgene.cziscience.com/) From c9cb4127ced1935e5af3d2cfd48da1e3dde11481 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 2 Feb 2024 16:52:49 -0500 Subject: [PATCH 099/176] Open Data Access Intro updates. --- open_access/introduction.md | 6 +++--- 1 file changed, 3 insertions(+), 3 deletions(-) diff --git a/open_access/introduction.md b/open_access/introduction.md index 80fe4974..0a987801 100644 --- a/open_access/introduction.md +++ b/open_access/introduction.md @@ -26,9 +26,9 @@ The HTAN Data Portal provides an overview of all publicly released data and link - Google BigQuery tables. - cBioPortal -Open Access Images can be downloaded from SB-CGC. +Open Access Images can be accessed and downloaded from SB-CGC as well as the IDC. -Google BigQuery Access provides direct access to a subset of assay data (mainly level 4 files) on a cloud platform. The Google BigQuery tables provide an easy way to build cohorts using spcific data fields. +Google BigQuery Access provides direct access to a subset of assay data (mainly level 4 files) on a cloud platform. The Google BigQuery tables provide an easy way to build cohorts using specific data fields. HTAN also provides sample code for working with the data in Google BigQuery. -!!! For more detailed information about the HTAN Portal, CellxGene, Visualizing Images, Accessing Images and/or Using Google BigQuery, please see the next sections of this manual. +!!! For more detailed information about the HTAN Portal, CellxGene, Visualizing Images, Accessing Images via SB-CGC and/or Using Google BigQuery, please see the next sections of this manual. !!! \ No newline at end of file From 5b1b789b556a833d2f3000a343bc84af0daf9bac Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 2 Feb 2024 16:55:09 -0500 Subject: [PATCH 100/176] Open Data Access Intro updates. --- open_access/introduction.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/open_access/introduction.md b/open_access/introduction.md index 0a987801..fd05539e 100644 --- a/open_access/introduction.md +++ b/open_access/introduction.md @@ -20,7 +20,7 @@ Open access HTAN data is available via the following services and tools: [!ref target="blank" text="cBioPortal"](https://www.cbioportal.org/) -The HTAN Data Portal provides an overview of all publicly released data and links to: +The HTAN Data Portal provides an overview of all released data. The Portal also provides links to: - CellxGene for visualization of single cell RNA-sequencing data - Minerva rendered images and stories. - Google BigQuery tables. From bc00c90c771b46628e1121fa93f30473a0d0f563 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 2 Feb 2024 16:57:11 -0500 Subject: [PATCH 101/176] Open Data Access Intro updates. --- open_access/introduction.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/open_access/introduction.md b/open_access/introduction.md index fd05539e..c42cf4df 100644 --- a/open_access/introduction.md +++ b/open_access/introduction.md @@ -30,5 +30,5 @@ Open Access Images can be accessed and downloaded from SB-CGC as well as the IDC Google BigQuery Access provides direct access to a subset of assay data (mainly level 4 files) on a cloud platform. The Google BigQuery tables provide an easy way to build cohorts using specific data fields. HTAN also provides sample code for working with the data in Google BigQuery. -!!! For more detailed information about the HTAN Portal, CellxGene, Visualizing Images, Accessing Images via SB-CGC and/or Using Google BigQuery, please see the next sections of this manual. +!!! For more detailed information about the HTAN Portal, CellxGene, Minerva-rendered Images, Accessing Images via SB-CGC and/or Using Google BigQuery, please see the next sections of this manual. !!! \ No newline at end of file From e4636cea07f91eeab6649082e60056a196ca5c8a Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 2 Feb 2024 17:01:41 -0500 Subject: [PATCH 102/176] ques of how to org open access data --- open_access/introduction.md | 3 +++ 1 file changed, 3 insertions(+) diff --git a/open_access/introduction.md b/open_access/introduction.md index c42cf4df..7727a7e7 100644 --- a/open_access/introduction.md +++ b/open_access/introduction.md @@ -4,6 +4,9 @@ order: 1000 # Open Access Data +:exclamation: might be best to break this into with each data release... data in HTAN portal, sb-cgc, bigquery...others are subset if data? + + Open access HTAN data is available via the following services and tools: [!ref target="blank" text="HTAN Data Portal"](https://data.humantumoratlas.org/explore) From 6888738cd08d5bc1a93b01271e00dd5a58379ce3 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Mon, 5 Feb 2024 12:47:20 -0500 Subject: [PATCH 103/176] adding caution to use synapseclient >= 3.0.0. --- data_pub_submission/clin_biospec_assay.md | 4 +++- 1 file changed, 3 insertions(+), 1 deletion(-) diff --git a/data_pub_submission/clin_biospec_assay.md b/data_pub_submission/clin_biospec_assay.md index 2494a429..f711f623 100644 --- a/data_pub_submission/clin_biospec_assay.md +++ b/data_pub_submission/clin_biospec_assay.md @@ -56,7 +56,9 @@ All data should be identified using HTAN identifiers. Please see the [HTAN Ident Please organize your data using the flattened data layout described in Synapse's [Data Ingress Docs](https://dca-docs.scrollhelp.site/DCA/Working-version/HTAN/organize-your-data-upload#OrganizeyourDataUpload-FlattenedDataLayoutExample) -Data files can be transferred using the Synapse User Interface (Synapse UI) or programmatically. Please see Synapse's [Data Ingress Docs](https://dca-docs.scrollhelp.site/DCA/Working-version/HTAN/uploading-data) for more information on how to upload files. +Data files can be transferred using the Synapse User Interface (Synapse UI) or programmatically. Please see Synapse's [Data Ingress Docs](https://dca-docs.scrollhelp.site/DCA/Working-version/HTAN/uploading-data) for more information on how to upload files. + +!!! If you upload files to Synapse programmatically, please use synapseclient version 3.0.0 or higher. !!! ## Validate and submit metadata using Synapse's Data Curator App (DCA). From 880f3960de3d7737b994a3676995822bba0f6610 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Mon, 5 Feb 2024 12:48:45 -0500 Subject: [PATCH 104/176] adding caution to use synapseclient >= 3.0.0. --- data_pub_submission/clin_biospec_assay.md | 3 ++- 1 file changed, 2 insertions(+), 1 deletion(-) diff --git a/data_pub_submission/clin_biospec_assay.md b/data_pub_submission/clin_biospec_assay.md index f711f623..ff150efc 100644 --- a/data_pub_submission/clin_biospec_assay.md +++ b/data_pub_submission/clin_biospec_assay.md @@ -58,7 +58,8 @@ Please organize your data using the flattened data layout described in Synapse's Data files can be transferred using the Synapse User Interface (Synapse UI) or programmatically. Please see Synapse's [Data Ingress Docs](https://dca-docs.scrollhelp.site/DCA/Working-version/HTAN/uploading-data) for more information on how to upload files. -!!! If you upload files to Synapse programmatically, please use synapseclient version 3.0.0 or higher. !!! +!!! If you upload files to Synapse programmatically, please use synapseclient version 3.0.0 or higher. +!!! ## Validate and submit metadata using Synapse's Data Curator App (DCA). From dc1c1503f3657328e1b79d14b11e0243ad1ee8aa Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 6 Feb 2024 15:09:15 -0500 Subject: [PATCH 105/176] removing comment by synapse in open access intro. --- open_access/introduction.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/open_access/introduction.md b/open_access/introduction.md index 7727a7e7..709ff1cc 100644 --- a/open_access/introduction.md +++ b/open_access/introduction.md @@ -11,7 +11,7 @@ Open access HTAN data is available via the following services and tools: [!ref target="blank" text="HTAN Data Portal"](https://data.humantumoratlas.org/explore) -[!ref target="blank" text="Synapse?"](https://synapse.org) :exclamation: data portal has "Synapse" as data access -- where is the data for public users of synapse? +[!ref target="blank" text="Synapse?"](https://synapse.org) [!ref target="blank" text="CellxGene"](https://cellxgene.cziscience.com/) From 4841c214539c0c260ffb73a83bc3d78df8dc73c3 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 6 Feb 2024 15:35:16 -0500 Subject: [PATCH 106/176] chgs to open access intro...simplified structure. --- open_access/introduction.md | 30 ++++++------------------------ 1 file changed, 6 insertions(+), 24 deletions(-) diff --git a/open_access/introduction.md b/open_access/introduction.md index 709ff1cc..ec730705 100644 --- a/open_access/introduction.md +++ b/open_access/introduction.md @@ -4,32 +4,14 @@ order: 1000 # Open Access Data -:exclamation: might be best to break this into with each data release... data in HTAN portal, sb-cgc, bigquery...others are subset if data? - - -Open access HTAN data is available via the following services and tools: - -[!ref target="blank" text="HTAN Data Portal"](https://data.humantumoratlas.org/explore) - -[!ref target="blank" text="Synapse?"](https://synapse.org) - -[!ref target="blank" text="CellxGene"](https://cellxgene.cziscience.com/) - -[!ref target="blank" text="The NCI Image Data Commons (IDC)"](https://portal.imaging.datacommons.cancer.gov/) - -[!ref target="blank" text="Seven Bridges-Cancer Genomic Cloud (SB-CGC)"](https://cgc-accounts.sbgenomics.com/) - -[!ref target="blank" text="Google BigQuery"](https://isb-cgc.appspot.com/) - -[!ref target="blank" text="cBioPortal"](https://www.cbioportal.org/) - -The HTAN Data Portal provides an overview of all released data. The Portal also provides links to: -- CellxGene for visualization of single cell RNA-sequencing data -- Minerva rendered images and stories. -- Google BigQuery tables. +The HTAN Data Portal provides an overview of all released data. For Open Access data, the Portal also provides links to: +- downloadable files on Synapse; +- CellxGene for visualization of single cell RNA-sequencing data; +- Minerva rendered images and stories; +- Google BigQuery tables; and - cBioPortal -Open Access Images can be accessed and downloaded from SB-CGC as well as the IDC. +Open Access Images can be accessed and downloaded from the NCI's Image Data Commons [(IDC)](https://portal.imaging.datacommons.cancer.gov/) as well as Seven Bridges-Cancer Genomic Cloud [(SB-CGC)](https://cgc-accounts.sbgenomics.com/). Google BigQuery Access provides direct access to a subset of assay data (mainly level 4 files) on a cloud platform. The Google BigQuery tables provide an easy way to build cohorts using specific data fields. HTAN also provides sample code for working with the data in Google BigQuery. From 8fe9fdf9ae73aa300a2971d0dead65dee5d18eee Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 6 Feb 2024 15:40:04 -0500 Subject: [PATCH 107/176] chgs to open access intro...simplified structure. --- open_access/introduction.md | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/open_access/introduction.md b/open_access/introduction.md index ec730705..e5f4c3f9 100644 --- a/open_access/introduction.md +++ b/open_access/introduction.md @@ -4,12 +4,12 @@ order: 1000 # Open Access Data -The HTAN Data Portal provides an overview of all released data. For Open Access data, the Portal also provides links to: +The [HTAN Data Portal](https://humantumoratlas.org/explore) provides an overview of all released data. For Open Access data, the Portal also provides links to: - downloadable files on Synapse; - CellxGene for visualization of single cell RNA-sequencing data; - Minerva rendered images and stories; - Google BigQuery tables; and -- cBioPortal +- cBioPortal. Open Access Images can be accessed and downloaded from the NCI's Image Data Commons [(IDC)](https://portal.imaging.datacommons.cancer.gov/) as well as Seven Bridges-Cancer Genomic Cloud [(SB-CGC)](https://cgc-accounts.sbgenomics.com/). From 4f2424e4f262a12a9a11999899299186feed6c8e Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 6 Feb 2024 15:43:25 -0500 Subject: [PATCH 108/176] chgs to open access intro...simplified structure. --- open_access/introduction.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/open_access/introduction.md b/open_access/introduction.md index e5f4c3f9..d83a9b37 100644 --- a/open_access/introduction.md +++ b/open_access/introduction.md @@ -13,7 +13,7 @@ The [HTAN Data Portal](https://humantumoratlas.org/explore) provides an overview Open Access Images can be accessed and downloaded from the NCI's Image Data Commons [(IDC)](https://portal.imaging.datacommons.cancer.gov/) as well as Seven Bridges-Cancer Genomic Cloud [(SB-CGC)](https://cgc-accounts.sbgenomics.com/). -Google BigQuery Access provides direct access to a subset of assay data (mainly level 4 files) on a cloud platform. The Google BigQuery tables provide an easy way to build cohorts using specific data fields. HTAN also provides sample code for working with the data in Google BigQuery. +Google BigQuery tables provide direct access to a subset of assay data (mainly level 4 files) on a cloud platform. The Google BigQuery tables provide an easy way to build cohorts using specific data fields. HTAN also provides sample code for working with the data in Google BigQuery. !!! For more detailed information about the HTAN Portal, CellxGene, Minerva-rendered Images, Accessing Images via SB-CGC and/or Using Google BigQuery, please see the next sections of this manual. !!! \ No newline at end of file From 4cca25fe422bf593325d9c8de5534ec6c5e3780b Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Wed, 7 Feb 2024 14:16:04 -0500 Subject: [PATCH 109/176] adding TNPs to Htan centers page. --- overview/centers.md | 6 ++---- 1 file changed, 2 insertions(+), 4 deletions(-) diff --git a/overview/centers.md b/overview/centers.md index 48dbc606..9e1244b3 100644 --- a/overview/centers.md +++ b/overview/centers.md @@ -6,10 +6,6 @@ order: 999 The HTAN Network consists of ten research centers, and two pilot projects. We also run multiple trans-network projects, referred to as TNPs. Each research center or TNP Project is identified with a unique HTAN prefix. -!!! Need to update table to include additional TNPs; Eventually need to update with new centers -:exclamation::exclamation: -!!! - | Prefix | Contact Institution or Project Name | Atlas Type | Area of Focus | | ------ | --------------------------------------- | ---------------- | --------------------------------- | | HTA1 | Human Tumor Atlas Pilot Project (HTAPP) | Tumor Atlas | Pilot Project | @@ -26,5 +22,7 @@ The HTAN Network consists of ten research centers, and two pilot projects. We al | HTA12 | Washington University in St. Louis | Tumor Atlas | Multiple Cancer Types | | HTA13 | TNP: SARDANA | TNP Atlas | Technology Comparison | | HTA14 | TNP: Tissue MicroArray (TMA) | TNP Atlas | Technology Comparison | +| HTA15 | TNP: SRRS | TNP Atlas | Technology Comparison | +| HTA16 | TNP: CASI | TNP Atlas | Technology Comparison | For details on each center, please see: https://humantumoratlas.org/research-network. From 84326c5bc01db8e86b6ef5a66b5b16ce3b837144 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Wed, 7 Feb 2024 14:43:32 -0500 Subject: [PATCH 110/176] add TNP page to additional information. --- addtnl_info/tnps.md | 7 +++++++ 1 file changed, 7 insertions(+) create mode 100644 addtnl_info/tnps.md diff --git a/addtnl_info/tnps.md b/addtnl_info/tnps.md new file mode 100644 index 00000000..1020e91c --- /dev/null +++ b/addtnl_info/tnps.md @@ -0,0 +1,7 @@ +--- +order: 996 +--- + +# Trans-Network Projects (TNPs) +Trans-Network Projects are multi-center projects created to facilitate collaborative research, such as cross-testing of experimental and analytical protocols, exchange of personnel to disseminate SOPs, or pursuit of additional HTAN critical methods or technologies. Specific information about each TNP is available on [HTAN's Synapse Wiki page](https://www.synapse.org/#!Synapse:syn17022193/wiki/584990) for HTAN members. Please contact :exclamation: ________________ :exclamation: if you a member of HTAN and need access to the wiki. + From 9d00e712d2abb3e4beb22f75bc2375876927488f Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Mon, 12 Feb 2024 09:10:39 -0500 Subject: [PATCH 111/176] TNP page -- added table and caution. --- addtnl_info/tnps.md | 11 +++++++++++ 1 file changed, 11 insertions(+) diff --git a/addtnl_info/tnps.md b/addtnl_info/tnps.md index 1020e91c..822727e3 100644 --- a/addtnl_info/tnps.md +++ b/addtnl_info/tnps.md @@ -5,3 +5,14 @@ order: 996 # Trans-Network Projects (TNPs) Trans-Network Projects are multi-center projects created to facilitate collaborative research, such as cross-testing of experimental and analytical protocols, exchange of personnel to disseminate SOPs, or pursuit of additional HTAN critical methods or technologies. Specific information about each TNP is available on [HTAN's Synapse Wiki page](https://www.synapse.org/#!Synapse:syn17022193/wiki/584990) for HTAN members. Please contact :exclamation: ________________ :exclamation: if you a member of HTAN and need access to the wiki. +Current Trans-Network Projects + +| Code | Name | Description | +---------------------------- +| HTA13 | TNP SARDANA | :exclamation: information needed | +| HTA14 | TNP TMA | :exclamation: information needed | +| HTA15 | TNP SRRS | :exclamation: information needed | +| HTA16 | TNP CASI | :exclamation: information needed | + +!!! Note: Samples used for TNPs may be derivatives of samples from pre-cancer or cancer atlases. For this reason, data from these projects should not be considered additional samples when re-using HTAN data !!! + From df7d20182fda917c55f82696b4cf5b754f9ae90f Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Mon, 12 Feb 2024 09:49:19 -0500 Subject: [PATCH 112/176] TNP page -- added table and caution. --- addtnl_info/tnps.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/addtnl_info/tnps.md b/addtnl_info/tnps.md index 822727e3..b6c7ebd0 100644 --- a/addtnl_info/tnps.md +++ b/addtnl_info/tnps.md @@ -8,7 +8,7 @@ Trans-Network Projects are multi-center projects created to facilitate collabora Current Trans-Network Projects | Code | Name | Description | ----------------------------- +|------|------|-------------| | HTA13 | TNP SARDANA | :exclamation: information needed | | HTA14 | TNP TMA | :exclamation: information needed | | HTA15 | TNP SRRS | :exclamation: information needed | From 48fbc643fff76ea284da7b12ac7634773a4f4b8d Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Mon, 12 Feb 2024 09:50:14 -0500 Subject: [PATCH 113/176] TNP page -- added table and caution. --- addtnl_info/tnps.md | 3 ++- 1 file changed, 2 insertions(+), 1 deletion(-) diff --git a/addtnl_info/tnps.md b/addtnl_info/tnps.md index b6c7ebd0..9e6870c9 100644 --- a/addtnl_info/tnps.md +++ b/addtnl_info/tnps.md @@ -14,5 +14,6 @@ Current Trans-Network Projects | HTA15 | TNP SRRS | :exclamation: information needed | | HTA16 | TNP CASI | :exclamation: information needed | -!!! Note: Samples used for TNPs may be derivatives of samples from pre-cancer or cancer atlases. For this reason, data from these projects should not be considered additional samples when re-using HTAN data !!! +!!! Note: Samples used for TNPs may be derivatives of samples from pre-cancer or cancer atlases. For this reason, data from these projects should not be considered additional samples when re-using HTAN data +!!! From bbe3a5423f2ce19f15e1af2a880818f6c621f40e Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Wed, 14 Feb 2024 09:30:38 -0500 Subject: [PATCH 114/176] adding information about submitting a data de-id plan. --- data_pub_submission/Data_Deidentification.md | 2 ++ data_pub_submission/Information_New_Centers.md | 2 +- 2 files changed, 3 insertions(+), 1 deletion(-) diff --git a/data_pub_submission/Data_Deidentification.md b/data_pub_submission/Data_Deidentification.md index 49ee7e36..de6b1def 100644 --- a/data_pub_submission/Data_Deidentification.md +++ b/data_pub_submission/Data_Deidentification.md @@ -21,6 +21,8 @@ By signing the HTAN DMSA, HTAN members’ institutional signing officials and PI In addition, the data are protected by an NIH Certificate of Confidentiality. +New HTAN Centers should develop and submit a De-identification Plan using the [HTAN Atlas De-Identification Plan Template](https://docs.google.com/document/d/1jFXYVMhLEGVcMNBh3L-U1rr4B-KLG7gK-ETc1SzMHhs/edit?usp=sharing). + Prior to transferring data to the HTAN DCC, members are responsible for fully de-identifying the data being transferred. Full de-identification of data includes confirmation that data file names do not contain any information that could be used to re-identify that data subject. diff --git a/data_pub_submission/Information_New_Centers.md b/data_pub_submission/Information_New_Centers.md index 6f7c6d9d..613310c1 100644 --- a/data_pub_submission/Information_New_Centers.md +++ b/data_pub_submission/Information_New_Centers.md @@ -12,6 +12,6 @@ All HTAN members must have an executed Human Tumor Atlas Network DMSA (Internal HTAN Centers are assigned a [data liaison](../data_pub_submission/Data_Liaisons.md) from the HTAN Data Coordinating Center [(DCC)](https://humantumoratlas.org/htan-dcc). Trans-Network Projects (TNPs) are also assigned liaisons. Your liaison will help guide you through setting up a new atlas or project, creating HTAN identifiers, filling out metadata sheets, and submitting data. Please keep your liaison informed of publications timelines and new data submissions. -Please see the appropriate page of this manual for additional details about HTAN center responsibilities for data de-identification and specific instructions regarding how to submit data. Clinical, biospecimen, and assay data submitted to the DCC are distributed to repositories based on access levels. Information regarding how data are accessed by external users is described more in [other parts of this manual](../overview/data_levels.md). +Please see the appropriate page of this manual for additional details about HTAN center responsibilities for data de-identification, including submitting a data de-identification plan, and specific instructions regarding how to submit data. Clinical, biospecimen, and assay data submitted to the DCC are distributed to repositories based on access levels. Information regarding how data are accessed by external users is described more in [other parts of this manual](../overview/data_levels.md). In order to support the FAIR (Findability, Accessibility, Interoperability, and Reusability) principles for scientific data production, the DCC has developed a [data model](../data_model/) based on established standards in the scientific research community. The HTAN Data Model is expected to evolve with advances in science. This evolution is a community-driven, peer-reviewed process, where members of a working group will first assess established community data standards and create a request for comment (RFC) document soliciting community feedback. The RFC process is described in more detail in later pages of this manual. We look forward to working with you and learning from your expertise as we improve upon our current model. From 0ecbb18a90418920edb8ace7c3cc8108319940bc Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Wed, 21 Feb 2024 12:48:53 -0500 Subject: [PATCH 115/176] testing email string in tool and protocol page. --- addtnl_info/tool_protocol.md | 6 +++++- 1 file changed, 5 insertions(+), 1 deletion(-) diff --git a/addtnl_info/tool_protocol.md b/addtnl_info/tool_protocol.md index f0ac8f04..4bc61786 100644 --- a/addtnl_info/tool_protocol.md +++ b/addtnl_info/tool_protocol.md @@ -4,7 +4,11 @@ order: 1000 # Tool and Protocol Curation -Computational tools developed or used to support HTAN research projects can be added to the HTAN tool catalog by filling out the tool curation form available on [HTAN's Synapse Wiki page](https://www.synapse.org/#!Synapse:syn17022193/wiki/584990). Please contact :exclamation: ________________ :exclamation: if you a member of HTAN and need access to the wiki. +Computational tools developed or used to support HTAN research projects can be added to the HTAN tool catalog by filling out the tool curation form available on [HTAN's Synapse Wiki page](https://www.synapse.org/#!Synapse:syn17022193/wiki/584990). Please contact + +email: htandcc@ds.dfci.harvard.edu + +if you a member of HTAN and need access to the wiki. :exclamation: Need information regarding how protols are developed/shared. From b05891686e73c9c1f626e5f6737c24f21473e315 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Wed, 21 Feb 2024 12:52:26 -0500 Subject: [PATCH 116/176] testing email string in tool and protocol page. --- addtnl_info/tool_protocol.md | 10 ++++++++-- 1 file changed, 8 insertions(+), 2 deletions(-) diff --git a/addtnl_info/tool_protocol.md b/addtnl_info/tool_protocol.md index 4bc61786..dc3fcdbd 100644 --- a/addtnl_info/tool_protocol.md +++ b/addtnl_info/tool_protocol.md @@ -4,11 +4,17 @@ order: 1000 # Tool and Protocol Curation -Computational tools developed or used to support HTAN research projects can be added to the HTAN tool catalog by filling out the tool curation form available on [HTAN's Synapse Wiki page](https://www.synapse.org/#!Synapse:syn17022193/wiki/584990). Please contact +Computational tools developed or used to support HTAN research projects can be added to the HTAN tool catalog by filling out the tool curation form available on [HTAN's Synapse Wiki page](https://www.synapse.org/#!Synapse:syn17022193/wiki/584990). + + +Information regarding how protocols are developed/shared is also available on [HTAN's Synapse Wiki page](https://www.synapse.org/#!Synapse:syn17022193/wiki/584990). + + +!!! The HTAN Synapse Wiki page is an internal resource for HTAN members. Please contact email: htandcc@ds.dfci.harvard.edu if you a member of HTAN and need access to the wiki. +!!! -:exclamation: Need information regarding how protols are developed/shared. From 731cf3446fb8b05ef6d269a0d75297b12489a386 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Wed, 21 Feb 2024 12:54:10 -0500 Subject: [PATCH 117/176] testing email string in tool and protocol page. --- addtnl_info/tool_protocol.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/addtnl_info/tool_protocol.md b/addtnl_info/tool_protocol.md index dc3fcdbd..b5e9a195 100644 --- a/addtnl_info/tool_protocol.md +++ b/addtnl_info/tool_protocol.md @@ -10,7 +10,7 @@ Computational tools developed or used to support HTAN research projects can be a Information regarding how protocols are developed/shared is also available on [HTAN's Synapse Wiki page](https://www.synapse.org/#!Synapse:syn17022193/wiki/584990). -!!! The HTAN Synapse Wiki page is an internal resource for HTAN members. Please contact +!!! The HTAN Synapse Wiki page is restricted to HTAN members. Please contact email: htandcc@ds.dfci.harvard.edu From eb298bf25e75ba4c680eaec90a8a1c7713133a00 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Wed, 21 Feb 2024 14:37:43 -0500 Subject: [PATCH 118/176] testing email string in tool and protocol page. --- addtnl_info/tool_protocol.md | 4 +++- 1 file changed, 3 insertions(+), 1 deletion(-) diff --git a/addtnl_info/tool_protocol.md b/addtnl_info/tool_protocol.md index b5e9a195..b45b12e6 100644 --- a/addtnl_info/tool_protocol.md +++ b/addtnl_info/tool_protocol.md @@ -10,7 +10,9 @@ Computational tools developed or used to support HTAN research projects can be a Information regarding how protocols are developed/shared is also available on [HTAN's Synapse Wiki page](https://www.synapse.org/#!Synapse:syn17022193/wiki/584990). -!!! The HTAN Synapse Wiki page is restricted to HTAN members. Please contact +!!! Note + +The HTAN Synapse Wiki page is restricted to HTAN members. Please contact email: htandcc@ds.dfci.harvard.edu From 7776230a4281e740d937f24b2d97c6295adea15a Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Wed, 21 Feb 2024 14:54:01 -0500 Subject: [PATCH 119/176] testing email string in tool and protocol page. --- addtnl_info/tool_protocol.md | 6 +----- 1 file changed, 1 insertion(+), 5 deletions(-) diff --git a/addtnl_info/tool_protocol.md b/addtnl_info/tool_protocol.md index b45b12e6..8cded11b 100644 --- a/addtnl_info/tool_protocol.md +++ b/addtnl_info/tool_protocol.md @@ -12,11 +12,7 @@ Information regarding how protocols are developed/shared is also available on [H !!! Note -The HTAN Synapse Wiki page is restricted to HTAN members. Please contact - -email: htandcc@ds.dfci.harvard.edu - -if you a member of HTAN and need access to the wiki. +The HTAN Synapse Wiki page is restricted to HTAN members. Please contact htandcc@ds.dfci.harvard.edu if you a member of HTAN and need access to the wiki. !!! From 8f98ff280388f4354e0f203d948743bfd9b66021 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Wed, 21 Feb 2024 14:54:32 -0500 Subject: [PATCH 120/176] testing email string in tool and protocol page. --- addtnl_info/tool_protocol.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/addtnl_info/tool_protocol.md b/addtnl_info/tool_protocol.md index 8cded11b..3d605cf1 100644 --- a/addtnl_info/tool_protocol.md +++ b/addtnl_info/tool_protocol.md @@ -12,7 +12,7 @@ Information regarding how protocols are developed/shared is also available on [H !!! Note -The HTAN Synapse Wiki page is restricted to HTAN members. Please contact htandcc@ds.dfci.harvard.edu if you a member of HTAN and need access to the wiki. +The HTAN Synapse Wiki page is restricted to HTAN members. Please contact htandcc@ds.dfci.harvard.edu if you are a member of HTAN and need access to the wiki. !!! From 4457bb384fa4511beeb986571729e8ae2ca52de8 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Wed, 21 Feb 2024 14:57:20 -0500 Subject: [PATCH 121/176] Adding contact email for synapse wiki access to relevant additional info pages. --- addtnl_info/WG_internal.md | 7 ++++++- addtnl_info/tnps.md | 8 +++++++- 2 files changed, 13 insertions(+), 2 deletions(-) diff --git a/addtnl_info/WG_internal.md b/addtnl_info/WG_internal.md index 1935ec4a..4e921123 100644 --- a/addtnl_info/WG_internal.md +++ b/addtnl_info/WG_internal.md @@ -4,4 +4,9 @@ order: 998 # Working Groups and Internal Communications -Information regarding Network Working Groups and Internal Communications can be found on [HTAN's Synapse Wiki page](https://www.synapse.org/#!Synapse:syn17022193/wiki/584990). Access to the HTAN Wiki is restricted to HTAN Members. Please contact :exclamation: ________________ :exclamation: if you a member of HTAN and need access to the wiki. \ No newline at end of file +Information regarding Network Working Groups and Internal Communications can be found on [HTAN's Synapse Wiki page](https://www.synapse.org/#!Synapse:syn17022193/wiki/584990). Access to the HTAN Wiki is restricted to HTAN Members. + +!!! Note + +The HTAN Synapse Wiki page is restricted to HTAN members. Please contact htandcc@ds.dfci.harvard.edu if you are a member of HTAN and need access to the wiki. +!!! diff --git a/addtnl_info/tnps.md b/addtnl_info/tnps.md index 9e6870c9..7d4dc1dd 100644 --- a/addtnl_info/tnps.md +++ b/addtnl_info/tnps.md @@ -3,7 +3,13 @@ order: 996 --- # Trans-Network Projects (TNPs) -Trans-Network Projects are multi-center projects created to facilitate collaborative research, such as cross-testing of experimental and analytical protocols, exchange of personnel to disseminate SOPs, or pursuit of additional HTAN critical methods or technologies. Specific information about each TNP is available on [HTAN's Synapse Wiki page](https://www.synapse.org/#!Synapse:syn17022193/wiki/584990) for HTAN members. Please contact :exclamation: ________________ :exclamation: if you a member of HTAN and need access to the wiki. +Trans-Network Projects are multi-center projects created to facilitate collaborative research, such as cross-testing of experimental and analytical protocols, exchange of personnel to disseminate SOPs, or pursuit of additional HTAN critical methods or technologies. Specific information about each TNP is available on [HTAN's Synapse Wiki page](https://www.synapse.org/#!Synapse:syn17022193/wiki/584990) for HTAN members. + +!!! Note + +The HTAN Synapse Wiki page is restricted to HTAN members. Please contact htandcc@ds.dfci.harvard.edu if you are a member of HTAN and need access to the wiki. +!!! + Current Trans-Network Projects From f693b30916f315d211addc678361a485fb0575d5 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Wed, 21 Feb 2024 15:21:45 -0500 Subject: [PATCH 122/176] Changed 4th bullet phrasing as per Lisa Pasquale's recommendation. --- data_pub_submission/Data_Deidentification.md | 4 +--- 1 file changed, 1 insertion(+), 3 deletions(-) diff --git a/data_pub_submission/Data_Deidentification.md b/data_pub_submission/Data_Deidentification.md index de6b1def..8d7bfcd9 100644 --- a/data_pub_submission/Data_Deidentification.md +++ b/data_pub_submission/Data_Deidentification.md @@ -17,9 +17,7 @@ By signing the HTAN DMSA, HTAN members’ institutional signing officials and PI - all data are consistent with applicable U.S. laws, regulations, and its institutional policies; and -- that an IRB/Privacy Board or equivalent body has assured that submission and subsequent sharing of data are consistent with the Informed Consent of the Data Subject(s) from whom the data were obtained. - -In addition, the data are protected by an NIH Certificate of Confidentiality. +- an IRB/Privacy Board or equivalent body has assured that submission and subsequent sharing of data are consistent with the Informed Consent of the Data Subject(s) from whom the data were obtained. In addition, the data are protected by an NIH Certificate of Confidentiality. New HTAN Centers should develop and submit a De-identification Plan using the [HTAN Atlas De-Identification Plan Template](https://docs.google.com/document/d/1jFXYVMhLEGVcMNBh3L-U1rr4B-KLG7gK-ETc1SzMHhs/edit?usp=sharing). From 8eef4125f29e404963cf332d8cd49595e4a16908 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Wed, 21 Feb 2024 15:32:10 -0500 Subject: [PATCH 123/176] UPdates to Info for New Centers based on feedback from Ashley Clayton. --- data_pub_submission/Information_New_Centers.md | 10 +++++----- 1 file changed, 5 insertions(+), 5 deletions(-) diff --git a/data_pub_submission/Information_New_Centers.md b/data_pub_submission/Information_New_Centers.md index 613310c1..6410d60f 100644 --- a/data_pub_submission/Information_New_Centers.md +++ b/data_pub_submission/Information_New_Centers.md @@ -4,14 +4,14 @@ order: 999 # Information for New HTAN Centers -Welcome to the HTAN Network! +Welcome to the Human Tumor Atlas Network! -Documents provided on the HTAN [resources page](https://humantumoratlas.org/resources) detail requirements for publications, data sharing and data use. +The [Resources page](https://humantumoratlas.org/resources) of the HTAN Data Portal provides documentation and applicable policies detailing the requirements for publications, data sharing, and data use. -All HTAN members must have an executed Human Tumor Atlas Network DMSA (Internal Data and Materials Sharing Agreement) [(HTAN DMSA)](https://docs.google.com/document/d/1RPFm9MBJv8DjZmYZyIv0jbjtNJ8fnwGjYDjlK4lL4nc/edit) with Sage Bionetworks prior to contributing data to the HTAN DCC. To initiate execution of the HTAN DMSA, contact Sage HTAN Governance (htan@sagebionetworks.jira.com). Please include the name and contact information of your HTAN PI and Institution Signatory to enable routing the HTAN DMSA for execution. +All HTAN members must have an executed Human Tumor Atlas Network DMSA (Internal Data and Materials Sharing Agreement) [(HTAN DMSA)](https://docs.google.com/document/d/1RPFm9MBJv8DjZmYZyIv0jbjtNJ8fnwGjYDjlK4lL4nc/edit) with Sage Bionetworks prior to contributing data to the HTAN Data Coordinating Center [(DCC)](https://humantumoratlas.org/htan-dcc). To initiate execution of the HTAN DMSA, contact Sage HTAN Governance (htan@sagebionetworks.jira.com). Please include the name and contact information of your HTAN PI and Institution Signatory to enable routing the HTAN DMSA for execution. -HTAN Centers are assigned a [data liaison](../data_pub_submission/Data_Liaisons.md) from the HTAN Data Coordinating Center [(DCC)](https://humantumoratlas.org/htan-dcc). Trans-Network Projects (TNPs) are also assigned liaisons. Your liaison will help guide you through setting up a new atlas or project, creating HTAN identifiers, filling out metadata sheets, and submitting data. Please keep your liaison informed of publications timelines and new data submissions. +HTAN Centers are assigned a [data liaison](../data_pub_submission/Data_Liaisons.md) from the [(DCC)](https://humantumoratlas.org/htan-dcc). Trans-Network Projects (TNPs) are also assigned liaisons. Your liaison will help guide you through setting up a new atlas or project, creating HTAN identifiers, filling out metadata sheets, and submitting data. Please keep your liaison informed of publications timelines and new data submissions. Please see the appropriate page of this manual for additional details about HTAN center responsibilities for data de-identification, including submitting a data de-identification plan, and specific instructions regarding how to submit data. Clinical, biospecimen, and assay data submitted to the DCC are distributed to repositories based on access levels. Information regarding how data are accessed by external users is described more in [other parts of this manual](../overview/data_levels.md). -In order to support the FAIR (Findability, Accessibility, Interoperability, and Reusability) principles for scientific data production, the DCC has developed a [data model](../data_model/) based on established standards in the scientific research community. The HTAN Data Model is expected to evolve with advances in science. This evolution is a community-driven, peer-reviewed process, where members of a working group will first assess established community data standards and create a request for comment (RFC) document soliciting community feedback. The RFC process is described in more detail in later pages of this manual. We look forward to working with you and learning from your expertise as we improve upon our current model. +In order to support the FAIR (Findability, Accessibility, Interoperability, and Reusability) principles for scientific data production, the DCC has developed a [data model](../data_model/) based on established standards in the scientific research community. The HTAN Data Model is expected to evolve with advances in science. This evolution is a community-driven, peer-reviewed process, where members of a working group will first assess established community data standards and create a request for comment (RFC) document soliciting community feedback. The RFC process is described in more detail in later pages of this manual. We look forward to working with you and learning from your expertise as we improve upon our current model. \ No newline at end of file From 4ae6b27cacef8b0e314aa1bb7fd69388cdc95597 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Wed, 21 Feb 2024 15:55:24 -0500 Subject: [PATCH 124/176] Adding changes suggested by Ashley Clayton. --- data_pub_submission/clin_biospec_assay.md | 14 +++++++------- 1 file changed, 7 insertions(+), 7 deletions(-) diff --git a/data_pub_submission/clin_biospec_assay.md b/data_pub_submission/clin_biospec_assay.md index ff150efc..66978a1c 100644 --- a/data_pub_submission/clin_biospec_assay.md +++ b/data_pub_submission/clin_biospec_assay.md @@ -6,11 +6,11 @@ order: 996 As stated in [Data and Publication Submission Overview](../data_pub_submission/overview.md), data submission involves two key steps: 1. Uploading assay data files to Synapse; and -2. Completing and validating manifests using the Data Curator App (DCA). +2. Completing and validating metadata using the Data Curator App (DCA). -This page provides more details regarding those steps. However, you will also need to understand the HTAN data model and specific requirements for your particular data type. For a general overview of the HTAN data model, please see [HTAN Data Model](../data_model.md). To understand specific requirements for your data type, please see [Data Standards](https://humantumoratlas.org/standards). +This page provides more details regarding those steps. However, you will also need to understand the HTAN data model and specific requirements for your particular data type. For a general overview of the HTAN data model, please see [HTAN Data Model](../data_model/overview.md). To understand specific requirements for your data type, please see [Data Standards](https://humantumoratlas.org/standards). -HTAN uses the Synapse [Web Portal](https:/www.synapse.org) and [DCA](https://dca.app.sagebionetworks.org/) to manage clinical, biospecimen and assay data submissions (dataset ingress). In order to submit data, your center should: +HTAN uses the Synapse [Portal](https://www.synapse.org) and [DCA](https://dca.app.sagebionetworks.org/), developed and maintained by [Sage Bionetworks](https://sagebionetworks.org/), to manage clinical, biospecimen and assay data submissions (dataset ingress). In order to submit data, your center should: 1. [Have at least one user with Certified User status on Synapse.](#have-at-least-one-user-with-certified-user-status-on-synapse) 2. [Contact your Data Liaison to set up your project and cloud bucket.](#contact-your-data-liaison-to-set-up-your-project-and-cloud-bucket) @@ -21,12 +21,12 @@ HTAN uses the Synapse [Web Portal](https:/www.synapse.org) and [DCA](https://dca Please read the rest of this page for more information about each of these steps. ## Have at least one user with Certified User status on Synapse. -To upload files to Synapse, you need to be a [certified user](https://help.synapse.org/docs/Synapse-User-Account-Types.2007072795.html). Because Synapse stores data from human subjects research, Sage Bionetworks requires that you demonstrate understanding of and compliance with privacy and security issues. You can complete your certification by taking a short certification quiz. Please see the Synapse [certified user documentation](https://help.synapse.org/docs/Synapse-User-Account-Types.2007072795.html) for more information. +To upload files to the Synapse Platform, you need to be a [Synapse Certified User](https://help.synapse.org/docs/Synapse-User-Account-Types.2007072795.html). Because Synapse stores data from human subjects research, Sage Bionetworks requires that you demonstrate understanding of and compliance with privacy and security issues. You can complete your certification by taking a short certification quiz. Please see the Synapse [Certified User Documentation](https://help.synapse.org/docs/Synapse-User-Account-Types.2007072795.html) for more information. ## Contact your Data Liaison to set up your project and cloud bucket. When you are ready to upload data, please contact your [data liaison](../data_pub_submission/Data_Liaisons.md). Your data liaison will need to know: -1. Your center +1. Your centers 2. Who on your team will be doing the data upload. 3. The synapse usernames for team members identified in #2. @@ -38,14 +38,14 @@ With the above information, the DCC will initialize your Synapse project for met The HTAN Data Model is built upon data standards described on the [Data Standards](https://data.humantumoratlas.org/standards) page. All HTAN Centers are required to encode their clinical, biospecimen and assay data and metadata using the HTAN Data Model. If you have a new data type which is not currently represented in the HTAN Data Model, please contact your data liaison. -A concrete way to understand the expectations for data submissions is to view the metadata templates for clinical, biospecimen and assay data available in Synapse's Data Curator App ([DCA](https://dca.app.sagebionetworks.org/)). For any given dataset, you may be submitting: +A concrete way to understand the expectations for data submissions is to view the metadata templates for clinical, biospecimen and assay data available in the ([DCA](https://dca.app.sagebionetworks.org/)). For any given dataset, you may be submitting: - clinical manifest(s), e.g. Demographics, Diagnosis - biospecimen manifest(s) - assay manifest(s), e.g. Bulk RNA-seq level 1 - assay data files -The first three items will be validated and submitted using the Data Curator App. The last item, assay data files, only needs to be uploaded to the synapse project itself. +The first three items will be validated and submitted using the DCA. The last item, assay data files, only needs to be uploaded to the synapse project itself. All data should be identified using HTAN identifiers. Please see the [HTAN Identifier](../data_model/identifiers.md) section of this manual for more information regarding HTAN identifiers. From 58e3be6624ff5b19a3ae6c55b4bc82968439f969 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Wed, 21 Feb 2024 16:04:40 -0500 Subject: [PATCH 125/176] Added HTAN Dashboard link to the data and pub Overview page. --- data_pub_submission/overview.md | 4 +++- 1 file changed, 3 insertions(+), 1 deletion(-) diff --git a/data_pub_submission/overview.md b/data_pub_submission/overview.md index 2fffcac1..45477df2 100644 --- a/data_pub_submission/overview.md +++ b/data_pub_submission/overview.md @@ -13,4 +13,6 @@ Data Submission involves two key steps: HTAN-associated publications are also submitted by completing and validating a manifest using the DCA. -Specific details regarding data submission and the DCA are included in later sections of this manual. Please contact your [Data Liaison](../data_pub_submission/Data_Liaisons.md) if you have any questions or issues. Please also keep your data liaison informed of any data or publication submissions. \ No newline at end of file +Specific details regarding data submission and the DCA are included in later sections of this manual. Please contact your [Data Liaison](../data_pub_submission/Data_Liaisons.md) if you have any questions or issues. Please also keep your data liaison informed of any data or publication submissions. + +The current status of data uploads (refreshed every 4 hours) is available on the [HTAN Dashboard](http://hdash.website-us-east-1.linodeobjects.com/index.html). \ No newline at end of file From 125f038e717e6db82b22b5fdc33ab0b72646cc8c Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Wed, 21 Feb 2024 16:09:07 -0500 Subject: [PATCH 126/176] minor grammatical correction. --- data_pub_submission/overview.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data_pub_submission/overview.md b/data_pub_submission/overview.md index 45477df2..392820ef 100644 --- a/data_pub_submission/overview.md +++ b/data_pub_submission/overview.md @@ -5,7 +5,7 @@ order: 1000 # Data and Publication Submission Overview Only HTAN Centers and Associate Members can submit data to the HTAN Network's repositories. The Data Submission Section of this Manual is intended as a guide for HTAN Centers and Associate Members. -:exclamation: *Prior to submitting data, all data must be de-identified. Please see [Data Deidentification](../data_pub_submission/Data_Deidentification.md) for more information.* +:exclamation: *Prior to submitting data, all data must be de-identified. Please see [Data De-identification](../data_pub_submission/Data_Deidentification.md) for more information.* Data Submission involves two key steps: 1. Uploading assay data files to Synapse; and From 05e57e3aaaf6a78f0801b1378c53bbfea7984632 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Mon, 26 Feb 2024 09:04:56 -0500 Subject: [PATCH 127/176] fixing ino's email address --- data_pub_submission/Data_Liaisons.md | 6 +++--- 1 file changed, 3 insertions(+), 3 deletions(-) diff --git a/data_pub_submission/Data_Liaisons.md b/data_pub_submission/Data_Liaisons.md index 368ca65a..09130bfe 100644 --- a/data_pub_submission/Data_Liaisons.md +++ b/data_pub_submission/Data_Liaisons.md @@ -13,11 +13,11 @@ Here is the current list of centers, their atlases and DCC liaisons: | PILOT - HTAPP | HTA1 | Vesteinn Thorsson | thorsson@isbscience.org | | PILOT - PCAPP | HTA2 | Ethan Cerami | cerami@ds.dfci.harvard.edu | | HTAN BU | HTA3 | Jennifer Altreuter | jennifer@ds.dfci.harvard.edu | -| HTAN CHOP | HTA4 | Ino de Bruijn | ebruiji@mskcc.org | +| HTAN CHOP | HTA4 | Ino de Bruijn | debruiji@mskcc.org | | HTAN DFCI | HTA5 | Jennifer Altreuter | jennifer@ds.dfci.harvard.edu | -| HTAN Duke | HTA6 | Ino de Bruijn | ebruiji@mskcc.org | +| HTAN Duke | HTA6 | Ino de Bruijn | debruiji@mskcc.org | | HTAN HMS | HTA7 | Adam Taylor | adam.taylor@sagebase.org | -| HTAN MSK | HTA8 | Ino de Bruijn | ebruiji@mskcc.org | +| HTAN MSK | HTA8 | Ino de Bruijn | debruiji@mskcc.org | | HTAN OHSU | HTA9 | Adam Taylor | adam.taylor@sagebase.org | | HTAN Stanford | HTA10 | Adam Taylor | adam.taylor@sagebase.org | | HTAN Vanderbilt | HTA11 | Clarisse Lau | clau@systemsbiology.org | From 5e36ffc5f3bab2f0b8f740b60f2b2795fb1c23b8 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Mon, 26 Feb 2024 10:04:26 -0500 Subject: [PATCH 128/176] new intro paragraph frm clarisse for data release. --- addtnl_info/data_release.md | 4 +++- 1 file changed, 3 insertions(+), 1 deletion(-) diff --git a/addtnl_info/data_release.md b/addtnl_info/data_release.md index 2f745c67..ea54ab48 100644 --- a/addtnl_info/data_release.md +++ b/addtnl_info/data_release.md @@ -4,4 +4,6 @@ order: 999 # Data Release -HTAN releases data at regular intervals. HTAN Centers are notified of the data submission deadline for an upcoming data release. After that deadline, the data release itself involves a number of data processing and verification steps. Please see [HTAN Data Release Process](https://docs.google.com/document/d/15xvIbfyQmgbMD_uB2e0SwPFw67_AePB5YspF4dsilCA/edit#heading=h.tddsmkcn4p1p) for more information regarding the data release process. \ No newline at end of file +The DCC prepares major data releases every 4-6 months. HTAN Centers are notified of the data submission deadline for an upcoming data release. After that deadline, the pre-release process involves a number of data processing and metadata verification steps. Data is released via the HTAN Data Portal, and then disseminated to various Cancer Data Research Commons (CRDC) nodes including Cancer Data Service (CDS) and the Institute for Systems Biology Cancer Gateway in the Cloud (ISB-CGC) to enable download of controlled-access data and long-term cloud access + +Please see [HTAN Data Release Process](https://docs.google.com/document/d/15xvIbfyQmgbMD_uB2e0SwPFw67_AePB5YspF4dsilCA/edit#heading=h.tddsmkcn4p1p) for more information regarding the data release process. \ No newline at end of file From e6c403c1f3669252319ffbeebbe4c1af9e0af475 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Mon, 26 Feb 2024 10:59:44 -0500 Subject: [PATCH 129/176] . --- .DS_Store | Bin 8196 -> 8196 bytes data_pub_submission/clin_biospec_assay.md | 2 +- data_pub_submission/specific_details.md | 2 +- 3 files changed, 2 insertions(+), 2 deletions(-) diff --git a/.DS_Store b/.DS_Store index e8551c28b8cfc384df3c93416cd0bd7bde99370a..a49065faac67cbea8836bebca0185ed69ea9b761 100644 GIT binary patch delta 166 zcmZp1XmOa}FUrQiz`)4BAi%&7&rrZn%8&%4i#HZdW1rZ-yP2JXg+m*pLYN_iA(5d3 zh>=u*Rp&BfG86-0CPO|$-efU>1~zje3mpa1$#Vo8jfvD&7F?8`~Nf$MCW O*(JWQY`!VX&I|xeiY0RZ delta 65 zcmZp1XmOa}FUrEez`)4BAiz*ukd%|31mx{VD%e;!jeTMR?`C!m77j+1%?5(k**2D| UFm7g-_{OqXQS2Gx#&ShQ05P%>Qvd(} diff --git a/data_pub_submission/clin_biospec_assay.md b/data_pub_submission/clin_biospec_assay.md index 66978a1c..2e9e0038 100644 --- a/data_pub_submission/clin_biospec_assay.md +++ b/data_pub_submission/clin_biospec_assay.md @@ -1,5 +1,5 @@ --- -order: 996 +order: 995 --- # Submitting Clinical, Biospecimen or Assay Data diff --git a/data_pub_submission/specific_details.md b/data_pub_submission/specific_details.md index 0dfc12ac..d445485c 100644 --- a/data_pub_submission/specific_details.md +++ b/data_pub_submission/specific_details.md @@ -1,5 +1,5 @@ --- -order: 995 +order: 994 --- # Specific Assay/Data Element Details From 0bef42ca0940e23ceee3f4038030a4bc0806d81b Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Mon, 26 Feb 2024 11:00:06 -0500 Subject: [PATCH 130/176] . --- data_pub_submission/clin_biospec_assay.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data_pub_submission/clin_biospec_assay.md b/data_pub_submission/clin_biospec_assay.md index 2e9e0038..66978a1c 100644 --- a/data_pub_submission/clin_biospec_assay.md +++ b/data_pub_submission/clin_biospec_assay.md @@ -1,5 +1,5 @@ --- -order: 995 +order: 996 --- # Submitting Clinical, Biospecimen or Assay Data From 0709eafc5d55ae365a106c7e0aa6d0299d9667ec Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Mon, 26 Feb 2024 11:38:50 -0500 Subject: [PATCH 131/176] adding diagram to the clin, biosp, assay page. --- .DS_Store | Bin 8196 -> 8196 bytes data_pub_submission/clin_biospec_assay.md | 4 +++- img/Data_submission.png | Bin 0 -> 55876 bytes 3 files changed, 3 insertions(+), 1 deletion(-) create mode 100644 img/Data_submission.png diff --git a/.DS_Store b/.DS_Store index a49065faac67cbea8836bebca0185ed69ea9b761..6ca3155e041c2288470d09a1a46aa328cc268ce5 100644 GIT binary patch delta 20 bcmZp1XmQxEO@P_b#B}mrL6^;c1=#rkPdNu4 delta 23 ecmZp1XmQxEO@PhZ$U;ZKbn*c~$IX8Q*!clp$_JtV diff --git a/data_pub_submission/clin_biospec_assay.md b/data_pub_submission/clin_biospec_assay.md index 66978a1c..df3ff7f5 100644 --- a/data_pub_submission/clin_biospec_assay.md +++ b/data_pub_submission/clin_biospec_assay.md @@ -4,11 +4,13 @@ order: 996 # Submitting Clinical, Biospecimen or Assay Data +![HTAN Data Submission Process](../img/Data_submission.png) + As stated in [Data and Publication Submission Overview](../data_pub_submission/overview.md), data submission involves two key steps: 1. Uploading assay data files to Synapse; and 2. Completing and validating metadata using the Data Curator App (DCA). -This page provides more details regarding those steps. However, you will also need to understand the HTAN data model and specific requirements for your particular data type. For a general overview of the HTAN data model, please see [HTAN Data Model](../data_model/overview.md). To understand specific requirements for your data type, please see [Data Standards](https://humantumoratlas.org/standards). +This page provides details regarding those steps. However, you will also need to understand the HTAN data model and specific requirements for your particular data type. For a general overview of the HTAN data model, please see [HTAN Data Model](../data_model/overview.md). To understand specific requirements for your data type, please see [Data Standards](https://humantumoratlas.org/standards). HTAN uses the Synapse [Portal](https://www.synapse.org) and [DCA](https://dca.app.sagebionetworks.org/), developed and maintained by [Sage Bionetworks](https://sagebionetworks.org/), to manage clinical, biospecimen and assay data submissions (dataset ingress). 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zwaY&K!;eZLe!Ug{f5KY`iDI7W_>5W^V8+bjTJa}>6ckk$^lqp+<|2J1ebBF){ From 342f6607d04ff555352f1f0e229e76c683e691fa Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Mon, 26 Feb 2024 11:43:04 -0500 Subject: [PATCH 133/176] Adding data submission graphic --- data_pub_submission/clin_biospec_assay.md | 8 +++++--- 1 file changed, 5 insertions(+), 3 deletions(-) diff --git a/data_pub_submission/clin_biospec_assay.md b/data_pub_submission/clin_biospec_assay.md index df3ff7f5..2b424847 100644 --- a/data_pub_submission/clin_biospec_assay.md +++ b/data_pub_submission/clin_biospec_assay.md @@ -4,13 +4,15 @@ order: 996 # Submitting Clinical, Biospecimen or Assay Data -![HTAN Data Submission Process](../img/Data_submission.png) - As stated in [Data and Publication Submission Overview](../data_pub_submission/overview.md), data submission involves two key steps: 1. Uploading assay data files to Synapse; and 2. Completing and validating metadata using the Data Curator App (DCA). -This page provides details regarding those steps. However, you will also need to understand the HTAN data model and specific requirements for your particular data type. For a general overview of the HTAN data model, please see [HTAN Data Model](../data_model/overview.md). To understand specific requirements for your data type, please see [Data Standards](https://humantumoratlas.org/standards). +This page provides details regarding those steps. + +![HTAN Data Submission Process](../img/Data_submission.png) + +To submit data, you will also need to understand the HTAN data model and specific requirements for your particular data type. For a general overview of the HTAN data model, please see [HTAN Data Model](../data_model/overview.md). To understand specific requirements for your data type, please see [Data Standards](https://humantumoratlas.org/standards). HTAN uses the Synapse [Portal](https://www.synapse.org) and [DCA](https://dca.app.sagebionetworks.org/), developed and maintained by [Sage Bionetworks](https://sagebionetworks.org/), to manage clinical, biospecimen and assay data submissions (dataset ingress). In order to submit data, your center should: From 231f326e35d43c6d0dfb00621213b1ddcf35b81d Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Mon, 26 Feb 2024 14:41:04 -0500 Subject: [PATCH 134/176] Add dta release diagram. --- addtnl_info/data_release.md | 7 +++++-- img/Data_release.png | Bin 0 -> 53802 bytes 2 files changed, 5 insertions(+), 2 deletions(-) create mode 100644 img/Data_release.png diff --git a/addtnl_info/data_release.md b/addtnl_info/data_release.md index ea54ab48..8d4d492b 100644 --- a/addtnl_info/data_release.md +++ b/addtnl_info/data_release.md @@ -4,6 +4,9 @@ order: 999 # Data Release -The DCC prepares major data releases every 4-6 months. HTAN Centers are notified of the data submission deadline for an upcoming data release. After that deadline, the pre-release process involves a number of data processing and metadata verification steps. Data is released via the HTAN Data Portal, and then disseminated to various Cancer Data Research Commons (CRDC) nodes including Cancer Data Service (CDS) and the Institute for Systems Biology Cancer Gateway in the Cloud (ISB-CGC) to enable download of controlled-access data and long-term cloud access +The Data Coordinating Center (DCC) prepares major data releases every 4-6 months. HTAN Centers are notified of the data submission deadline for an upcoming data release. After that deadline, the pre-release process involves a number of data processing and metadata verification steps. Data is released via the HTAN Data Portal, and then disseminated to various Cancer Data Research Commons (CRDC) nodes including Cancer Data Service (CDS) and the Institute for Systems Biology Cancer Gateway in the Cloud (ISB-CGC) to enable download of controlled-access data and long-term cloud access + +![The HTAN Data Release Process](../img/Data_release.png) + +Please see [HTAN Data Release Process](https://docs.google.com/document/d/15xvIbfyQmgbMD_uB2e0SwPFw67_AePB5YspF4dsilCA/edit#heading=h.tddsmkcn4p1p) for more information regarding the data release process. -Please see [HTAN Data Release Process](https://docs.google.com/document/d/15xvIbfyQmgbMD_uB2e0SwPFw67_AePB5YspF4dsilCA/edit#heading=h.tddsmkcn4p1p) for more information regarding the data release process. \ No newline at end of file diff --git a/img/Data_release.png b/img/Data_release.png new file mode 100644 index 0000000000000000000000000000000000000000..3f8b4e7ad6cbbb887f2116940b5d9fa054936e05 GIT binary patch literal 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Note: Samples used for TNPs may be derivatives of samples from pre-cancer or cancer atlases. For this reason, data from these projects should not be considered additional samples when re-using HTAN data -!!! +| HTA13 | TNP SARDANA | The **S**h**a**red **R**epositories, **D**ata, **An**alysis and **A**ccess TNP focuses on optimizing the repeatability, interpretability and accessibility of HTAN characterization methods and the data they generate. | +| HTA14 | TNP TMA | The **T**issue **M**icro**A**rray TNP extends the TNP SARDANA characterization and analytics methodologies for evaluation and validation to a large array of breast tumor TMA samples that provide a broad spectrum of disease state and subtype. | +| HTA15 | TNP SRRS | The **S**tandardized **R**epository of **R**eference **S**pecimens TNP's mission is to assemble an extensive catalogue of cases from premalignant lesions, pre- and post-treatment tumor tissue and metastatic tumor tissue for protocol optimization and validation. | +| HTA16 | TNP CASI | The goal of the **C**ell **A**nnotations and **S**ignatures **I**nitiative TNP is to provide robust and accurate tools for cell type annotation from single-cell data. | From 20def142994f968cdc931a4ae5e9e0a1a5bc5fe7 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 27 Feb 2024 10:48:29 -0500 Subject: [PATCH 142/176] minor edits to tnp table. --- addtnl_info/tnps.md | 5 ++--- 1 file changed, 2 insertions(+), 3 deletions(-) diff --git a/addtnl_info/tnps.md b/addtnl_info/tnps.md index 05c9211d..2bc1bf0d 100644 --- a/addtnl_info/tnps.md +++ b/addtnl_info/tnps.md @@ -16,7 +16,6 @@ Current Trans-Network Projects | Code | Name | Description | |------|------|-------------| | HTA13 | TNP SARDANA | The **S**h**a**red **R**epositories, **D**ata, **An**alysis and **A**ccess TNP focuses on optimizing the repeatability, interpretability and accessibility of HTAN characterization methods and the data they generate. | -| HTA14 | TNP TMA | The **T**issue **M**icro**A**rray TNP extends the TNP SARDANA characterization and analytics methodologies for evaluation and validation to a large array of breast tumor TMA samples that provide a broad spectrum of disease state and subtype. | +| HTA14 | TNP TMA | The **T**issue **M**icro**A**rray TNP extends the TNP SARDANA characterization and analytics methodologies for evaluation and validation to a large array of breast tumor TMA samples that provide a broad spectrum of disease states and subtypes. | | HTA15 | TNP SRRS | The **S**tandardized **R**epository of **R**eference **S**pecimens TNP's mission is to assemble an extensive catalogue of cases from premalignant lesions, pre- and post-treatment tumor tissue and metastatic tumor tissue for protocol optimization and validation. | -| HTA16 | TNP CASI | The goal of the **C**ell **A**nnotations and **S**ignatures **I**nitiative TNP is to provide robust and accurate tools for cell type annotation from single-cell data. | - +| HTA16 | TNP CASI | The goal of the **C**ell **A**nnotations and **S**ignatures **I**nitiative TNP is to provide robust and accurate tools for cell type annotation from single-cell data. | \ No newline at end of file From e7f5381ea28ecf4db4241ebeafb418c30f8026ba Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 27 Feb 2024 15:57:49 -0500 Subject: [PATCH 143/176] minor edit open access intro --- open_access/introduction.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/open_access/introduction.md b/open_access/introduction.md index d83a9b37..8f07601f 100644 --- a/open_access/introduction.md +++ b/open_access/introduction.md @@ -15,5 +15,5 @@ Open Access Images can be accessed and downloaded from the NCI's Image Data Comm Google BigQuery tables provide direct access to a subset of assay data (mainly level 4 files) on a cloud platform. The Google BigQuery tables provide an easy way to build cohorts using specific data fields. HTAN also provides sample code for working with the data in Google BigQuery. -!!! For more detailed information about the HTAN Portal, CellxGene, Minerva-rendered Images, Accessing Images via SB-CGC and/or Using Google BigQuery, please see the next sections of this manual. +!!! 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zbh-;#_Ntqg^h#tP(a7ija&@rZKnCK>nu$VrYDr?{-BDP<1a`68)5g+x57Y`A#@7Ac zvt44?WXmuZ!pe@;+@piekNp^cb#MS&L6-AQxpl1%X`-+*X^S3fX+W~9>PiC81kbB1 z3++yBHvA`!>f#6WJ*C24gn+puS{bH64)Hl0#;?JoY_k=cH1S`s@Wc zL2X%U(8ja^1oP$ITd&h1ng?|3&gyIu3a$;`4xt@g#AfKvG{??`IlHX=_)vgdOfG|B z{F(NFxh>u?gYnEQs}Z9>t7Z@u7auCjfZF!J1i}5TuJ3OED!wULqRMG3V-2gcv;pwJ zP-IF2dOV> z8o-W^<-WX>eWE&_EX&{h=*bD|^UO6?Xx#;PD0se>Wkl-b(t%a)0@m) a=b Date: Tue, 27 Feb 2024 16:11:54 -0500 Subject: [PATCH 146/176] Change to data_release.svg to be compatible with browser dark mode --- addtnl_info/data_release.md | 2 +- img/Data_release.png | Bin 56013 -> 0 bytes img/Data_release.svg | 1 + 3 files changed, 2 insertions(+), 1 deletion(-) delete mode 100644 img/Data_release.png create mode 100644 img/Data_release.svg diff --git a/addtnl_info/data_release.md b/addtnl_info/data_release.md index 8d4d492b..468c0512 100644 --- a/addtnl_info/data_release.md +++ b/addtnl_info/data_release.md @@ -6,7 +6,7 @@ order: 999 The Data Coordinating Center (DCC) prepares major data releases every 4-6 months. HTAN Centers are notified of the data submission deadline for an upcoming data release. After that deadline, the pre-release process involves a number of data processing and metadata verification steps. Data is released via the HTAN Data Portal, and then disseminated to various Cancer Data Research Commons (CRDC) nodes including Cancer Data Service (CDS) and the Institute for Systems Biology Cancer Gateway in the Cloud (ISB-CGC) to enable download of controlled-access data and long-term cloud access -![The HTAN Data Release Process](../img/Data_release.png) +![The HTAN Data Release Process](../img/Data_release.svg) Please see [HTAN Data Release Process](https://docs.google.com/document/d/15xvIbfyQmgbMD_uB2e0SwPFw67_AePB5YspF4dsilCA/edit#heading=h.tddsmkcn4p1p) for more information regarding the data release process. diff --git a/img/Data_release.png b/img/Data_release.png deleted file mode 100644 index d5712553f12deba5a04325736cf37b4bb0410b34..0000000000000000000000000000000000000000 GIT binary patch literal 0 HcmV?d00001 literal 56013 zcmcG#WmH^C*ENa-3Em_jxHTFqxNGC?1hzKnD$;#v6Bs;0YR>MuG-{I|O(7 z_IaLj&imdU_m1z+*MIgHJ$CJ?TC3KonzQDDXsRpVKP7*Pf`WptqzKYRK|zC}prGzz 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b/data_pub_submission/clin_biospec_assay.md index 2b424847..f4cb7348 100644 --- a/data_pub_submission/clin_biospec_assay.md +++ b/data_pub_submission/clin_biospec_assay.md @@ -10,7 +10,7 @@ As stated in [Data and Publication Submission Overview](../data_pub_submission/o This page provides details regarding those steps. -![HTAN Data Submission Process](../img/Data_submission.png) +![HTAN Data Submission Process](../img/Data_submission.svg) To submit data, you will also need to understand the HTAN data model and specific requirements for your particular data type. For a general overview of the HTAN data model, please see [HTAN Data Model](../data_model/overview.md). To understand specific requirements for your data type, please see [Data Standards](https://humantumoratlas.org/standards). diff --git a/img/Data_submission.png b/img/Data_submission.png deleted file mode 100644 index b5baf934127a457d0aec79fd6369a6322f5bd2a8..0000000000000000000000000000000000000000 GIT binary patch literal 0 HcmV?d00001 literal 65302 zcmd>lWm{ZLv}NN-fZ(pdo#5^k+^w< zr)>qXtA{?1W2Q;NHbs{1NxS2x_uFo6^~=X2=Ym|LUx8Wvzx&YPsAJY?T>Z*T!irR8 zSDhRZwbgWqHDSjeqxDar(`J<{dHir$+&@CckCIUtp34~~iUa~_{wq0b%dLT*@dgcj zC?QwVEE+3vjX8*|V8W-|^bAtfW5p!tY~+%!yNC3fja zw_a3}R1@Rej!K_aefh(amc>Wg!{;vpH&vDDLT88O$YlP{WqvcMBm|J7jQRAKkIXh* zvGdE>q4l%AhY)r{M4?I&v3{R>vvSo+e(me^=LXm#TX4TywoHJ}lnpBt-Tbght!&c` zrbH#(LD9hJ1|u{`CdKHm%?KL(scmc1RkYR3)n>2bI#{RFj^Ntj_*v-M-p6fBRz5co z$ttGteuXol*4ae|`+inF)k0_G_H;e*Xg4WMH`};RQ2o|st>q7jyA^R`hcw5jn7Yp> zWTZN8RaUaw4(33hXjv%*QmyD3aPUW=7i2O>MLWsY>Brh?xA(HsFtg^|AIEia%DWec zQR(xdi@Bds?0dQPYD!A(d-q6ibm&UXK3U&iDt!<1IvmRYrvHXjw!KFv@TTLN 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b/img/Data_submission.svg @@ -0,0 +1 @@ + \ No newline at end of file From 42885573012d13a02a080f8659b627c632b793df Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 27 Feb 2024 16:22:16 -0500 Subject: [PATCH 148/176] fixed minor error on data_release.svg --- img/Data_release.svg | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/img/Data_release.svg b/img/Data_release.svg index 469c9159..6e5b616e 100644 --- a/img/Data_release.svg +++ b/img/Data_release.svg @@ -1 +1 @@ - \ No newline at end of file + \ No newline at end of file From f8153c90e80910fb4cd45e107a40326d27ead6b6 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 27 Feb 2024 17:18:12 -0500 Subject: [PATCH 149/176] Adding What is metadata? --- data_pub_submission/Information_New_Centers.md | 2 +- data_pub_submission/clin_biospec_assay.md | 6 +++--- data_pub_submission/metadata.md | 15 +++++++++++++++ data_pub_submission/publications.md | 2 +- data_pub_submission/specific_details.md | 2 +- 5 files changed, 21 insertions(+), 6 deletions(-) create mode 100644 data_pub_submission/metadata.md diff --git a/data_pub_submission/Information_New_Centers.md b/data_pub_submission/Information_New_Centers.md index 6410d60f..0705e3b8 100644 --- a/data_pub_submission/Information_New_Centers.md +++ b/data_pub_submission/Information_New_Centers.md @@ -10,7 +10,7 @@ The [Resources page](https://humantumoratlas.org/resources) of the HTAN Data Por All HTAN members must have an executed Human Tumor Atlas Network DMSA (Internal Data and Materials Sharing Agreement) [(HTAN DMSA)](https://docs.google.com/document/d/1RPFm9MBJv8DjZmYZyIv0jbjtNJ8fnwGjYDjlK4lL4nc/edit) with Sage Bionetworks prior to contributing data to the HTAN Data Coordinating Center [(DCC)](https://humantumoratlas.org/htan-dcc). To initiate execution of the HTAN DMSA, contact Sage HTAN Governance (htan@sagebionetworks.jira.com). Please include the name and contact information of your HTAN PI and Institution Signatory to enable routing the HTAN DMSA for execution. -HTAN Centers are assigned a [data liaison](../data_pub_submission/Data_Liaisons.md) from the [(DCC)](https://humantumoratlas.org/htan-dcc). Trans-Network Projects (TNPs) are also assigned liaisons. Your liaison will help guide you through setting up a new atlas or project, creating HTAN identifiers, filling out metadata sheets, and submitting data. Please keep your liaison informed of publications timelines and new data submissions. +HTAN Centers are assigned a [data liaison](../data_pub_submission/Data_Liaisons.md) from the [(DCC)](https://humantumoratlas.org/htan-dcc). Trans-Network Projects (TNPs) are also assigned liaisons. Your liaison will help guide you through setting up a new atlas or project, creating HTAN identifiers, and submitting metadata and data files. Please keep your liaison informed of publications timelines and new data submissions. Please see the appropriate page of this manual for additional details about HTAN center responsibilities for data de-identification, including submitting a data de-identification plan, and specific instructions regarding how to submit data. Clinical, biospecimen, and assay data submitted to the DCC are distributed to repositories based on access levels. Information regarding how data are accessed by external users is described more in [other parts of this manual](../overview/data_levels.md). diff --git a/data_pub_submission/clin_biospec_assay.md b/data_pub_submission/clin_biospec_assay.md index f4cb7348..1a98a3e9 100644 --- a/data_pub_submission/clin_biospec_assay.md +++ b/data_pub_submission/clin_biospec_assay.md @@ -1,8 +1,8 @@ --- -order: 996 +order: 995 --- -# Submitting Clinical, Biospecimen or Assay Data +# Submitting Assay Data and Metadata As stated in [Data and Publication Submission Overview](../data_pub_submission/overview.md), data submission involves two key steps: 1. Uploading assay data files to Synapse; and @@ -42,7 +42,7 @@ With the above information, the DCC will initialize your Synapse project for met The HTAN Data Model is built upon data standards described on the [Data Standards](https://data.humantumoratlas.org/standards) page. All HTAN Centers are required to encode their clinical, biospecimen and assay data and metadata using the HTAN Data Model. If you have a new data type which is not currently represented in the HTAN Data Model, please contact your data liaison. -A concrete way to understand the expectations for data submissions is to view the metadata templates for clinical, biospecimen and assay data available in the ([DCA](https://dca.app.sagebionetworks.org/)). For any given dataset, you may be submitting: +A concrete way to understand the expectations for data submissions is to view the metadata templates (manifests) for clinical, biospecimen and assay data available in the ([DCA](https://dca.app.sagebionetworks.org/)). For any given dataset, you may be submitting: - clinical manifest(s), e.g. Demographics, Diagnosis - biospecimen manifest(s) diff --git a/data_pub_submission/metadata.md b/data_pub_submission/metadata.md new file mode 100644 index 00000000..edc2031b --- /dev/null +++ b/data_pub_submission/metadata.md @@ -0,0 +1,15 @@ +--- +order: 996 +--- + +# What is Metadata? + +Metadata traditionally means data *about* data. Metadata enables both data searchability and interpretability. Examples include sample and case identifiers, biospecimen information (e.g. tumor type), patient information (e.g. demographics) and assay-specific information (e.g. experiment protocol, assay reagents or assay technology). + +HTAN's [Data Model](../data_model/overview.md) is a framework for collecting and storing metadata. The Data Model in turn supports effective searching for data on [HTAN's Data Portal](https://humantumoratlas.org/explore). + +Metadata is submitted to HTAN via the Synapse Data Curator App [DCA](https://dca.app.sagebionetworks.org/), developed and maintained by [Sage Bionetworks](https://sagebionetworks.org/). The DCA performs several automated validation checks to make sure the metadata complies with the HTAN Data Model. Please see [Submitting Data Files and Metadata](../data_pub_submission/clin_biospec_assay.md) for more information about the DCA. + +!!! Terminology Alert +The term "manifests" refers to the spreadsheets used to submit metadata. "Metadata templates" are available via the DCA. These are manifests which can be filled out, validated and submitted using the DCA's web interface. +!!! \ No newline at end of file diff --git a/data_pub_submission/publications.md b/data_pub_submission/publications.md index 36b77e53..fa2b02b6 100644 --- a/data_pub_submission/publications.md +++ b/data_pub_submission/publications.md @@ -1,5 +1,5 @@ --- -order: 994 +order: 992 --- # Submitting Publications diff --git a/data_pub_submission/specific_details.md b/data_pub_submission/specific_details.md index d445485c..0a426614 100644 --- a/data_pub_submission/specific_details.md +++ b/data_pub_submission/specific_details.md @@ -1,5 +1,5 @@ --- -order: 994 +order: 993 --- # Specific Assay/Data Element Details From 8b04c60384bacdb4e74e4a429a14374ba7348e57 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 27 Feb 2024 17:40:38 -0500 Subject: [PATCH 150/176] adding graphic to what is metadata --- data_pub_submission/metadata.md | 4 +++- img/metadata.svg | 1 + 2 files changed, 4 insertions(+), 1 deletion(-) create mode 100644 img/metadata.svg diff --git a/data_pub_submission/metadata.md b/data_pub_submission/metadata.md index edc2031b..97fa7bee 100644 --- a/data_pub_submission/metadata.md +++ b/data_pub_submission/metadata.md @@ -4,7 +4,9 @@ order: 996 # What is Metadata? -Metadata traditionally means data *about* data. Metadata enables both data searchability and interpretability. Examples include sample and case identifiers, biospecimen information (e.g. tumor type), patient information (e.g. demographics) and assay-specific information (e.g. experiment protocol, assay reagents or assay technology). +Metadata traditionally means data *about* data. Metadata enables both data searchability and interpretability. Examples include sample and case identifiers, biospecimen information (e.g. tumor type), patient information (e.g. demographics) and assay-specific information (e.g. experiment protocol, assay reagents or assay technology). + +![Example HTAN Metadata vs Assay Data](../img/metadata.svg) HTAN's [Data Model](../data_model/overview.md) is a framework for collecting and storing metadata. The Data Model in turn supports effective searching for data on [HTAN's Data Portal](https://humantumoratlas.org/explore). diff --git a/img/metadata.svg b/img/metadata.svg new file mode 100644 index 00000000..1958eb55 --- /dev/null +++ b/img/metadata.svg @@ -0,0 +1 @@ + \ No newline at end of file From 0288cad03b09f643b5f5e42bd28f9fbcd556e007 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 27 Feb 2024 17:42:41 -0500 Subject: [PATCH 151/176] correction to metadata.svg --- img/metadata.svg | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/img/metadata.svg b/img/metadata.svg index 1958eb55..de7fb0a1 100644 --- a/img/metadata.svg +++ b/img/metadata.svg @@ -1 +1 @@ - \ No newline at end of file + \ No newline at end of file From 51e5b5ff5cfda9027217fba82d38c603863384f5 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 27 Feb 2024 17:44:46 -0500 Subject: [PATCH 152/176] minor grammar edit --- data_pub_submission/metadata.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data_pub_submission/metadata.md b/data_pub_submission/metadata.md index 97fa7bee..ff2b6885 100644 --- a/data_pub_submission/metadata.md +++ b/data_pub_submission/metadata.md @@ -10,7 +10,7 @@ Metadata traditionally means data *about* data. Metadata enables both data sear HTAN's [Data Model](../data_model/overview.md) is a framework for collecting and storing metadata. The Data Model in turn supports effective searching for data on [HTAN's Data Portal](https://humantumoratlas.org/explore). -Metadata is submitted to HTAN via the Synapse Data Curator App [DCA](https://dca.app.sagebionetworks.org/), developed and maintained by [Sage Bionetworks](https://sagebionetworks.org/). The DCA performs several automated validation checks to make sure the metadata complies with the HTAN Data Model. Please see [Submitting Data Files and Metadata](../data_pub_submission/clin_biospec_assay.md) for more information about the DCA. +Metadata is submitted to HTAN via the Synapse Data Curator App [(DCA)](https://dca.app.sagebionetworks.org/), developed and maintained by [Sage Bionetworks](https://sagebionetworks.org/). The DCA performs several automated validation checks to make sure the metadata complies with the HTAN Data Model. Please see [Submitting Data Files and Metadata](../data_pub_submission/clin_biospec_assay.md) for more information about the DCA. !!! Terminology Alert The term "manifests" refers to the spreadsheets used to submit metadata. "Metadata templates" are available via the DCA. These are manifests which can be filled out, validated and submitted using the DCA's web interface. From 7fc1a5b363e50cbb038ec5a3ff1aacc247732bb4 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 27 Feb 2024 17:49:43 -0500 Subject: [PATCH 153/176] minor edits to what is metadata --- data_pub_submission/metadata.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data_pub_submission/metadata.md b/data_pub_submission/metadata.md index ff2b6885..41facba0 100644 --- a/data_pub_submission/metadata.md +++ b/data_pub_submission/metadata.md @@ -4,7 +4,7 @@ order: 996 # What is Metadata? -Metadata traditionally means data *about* data. Metadata enables both data searchability and interpretability. Examples include sample and case identifiers, biospecimen information (e.g. tumor type), patient information (e.g. demographics) and assay-specific information (e.g. experiment protocol, assay reagents or assay technology). +Metadata means data *about* data. Metadata enables both data searchability and interpretability. For HTAN, this includes sample and case identifiers, patient information (e.g. demographics), biospecimen information (e.g. tumor type), and assay-specific information (e.g. experiment protocol, assay reagents or assay technology). ![Example HTAN Metadata vs Assay Data](../img/metadata.svg) From dacd4c0f934cbcff00aa78d7dcd506e7324fd047 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 27 Feb 2024 17:53:49 -0500 Subject: [PATCH 154/176] make metadata.svg larger --- img/metadata.svg | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/img/metadata.svg b/img/metadata.svg index de7fb0a1..82eee891 100644 --- a/img/metadata.svg +++ b/img/metadata.svg @@ -1 +1 @@ - \ No newline at end of file + \ No newline at end of file From 2ed0068f0f46fd640aa73f021730019c3f215bcc Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Thu, 29 Feb 2024 15:12:20 -0500 Subject: [PATCH 155/176] chg to data_relase image, 12 wks to CDS --- img/Data_release.svg | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/img/Data_release.svg b/img/Data_release.svg index 6e5b616e..67878ebc 100644 --- a/img/Data_release.svg +++ b/img/Data_release.svg @@ -1 +1 @@ - \ No newline at end of file + \ No newline at end of file From 37d68d1c0678ce80f3aabbd9475b71e9fd047b3b Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 1 Mar 2024 17:06:02 -0500 Subject: [PATCH 156/176] Adding figure to data and publication submission. --- data_pub_submission/overview.md | 2 ++ img/Data_Pub_Overview.svg | 1 + 2 files changed, 3 insertions(+) create mode 100644 img/Data_Pub_Overview.svg diff --git a/data_pub_submission/overview.md b/data_pub_submission/overview.md index 392820ef..1774dd46 100644 --- a/data_pub_submission/overview.md +++ b/data_pub_submission/overview.md @@ -13,6 +13,8 @@ Data Submission involves two key steps: HTAN-associated publications are also submitted by completing and validating a manifest using the DCA. +![Data and Publication Submission Overview](../img/Data_Pub_Overview.svg) + Specific details regarding data submission and the DCA are included in later sections of this manual. Please contact your [Data Liaison](../data_pub_submission/Data_Liaisons.md) if you have any questions or issues. Please also keep your data liaison informed of any data or publication submissions. The current status of data uploads (refreshed every 4 hours) is available on the [HTAN Dashboard](http://hdash.website-us-east-1.linodeobjects.com/index.html). \ No newline at end of file diff --git a/img/Data_Pub_Overview.svg b/img/Data_Pub_Overview.svg new file mode 100644 index 00000000..d6bfb046 --- /dev/null +++ b/img/Data_Pub_Overview.svg @@ -0,0 +1 @@ + \ No newline at end of file From 53d1aebb099986e7d98a6e70dbcb6d94ccc67b9a Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 12 Mar 2024 14:30:39 -0400 Subject: [PATCH 157/176] Adding place holder for eventual data standards migration to the manual. --- data_model/data_standards.md | 11 +++++++++++ 1 file changed, 11 insertions(+) create mode 100644 data_model/data_standards.md diff --git a/data_model/data_standards.md b/data_model/data_standards.md new file mode 100644 index 00000000..cf3077b0 --- /dev/null +++ b/data_model/data_standards.md @@ -0,0 +1,11 @@ +--- +order: 997 +--- + +# Data Standards + +This page is a place holder for data standards page/set of data standards pages similar to [MC2 Center Data Model](https://mc2-center.github.io/data-models/). The HTAN version of the MCS tables will include additional columns such as "required_if_component" and "required_if_value". See [data-models issue#354](https://github.com/ncihtan/data-models/issues/354) for more information. + +!!! Note +Once these pages are added, the [Data Standards](https://humantumoratlas.org/standards) page will be removed from the data portal. All links to "Data Standards" throughout this manual will need to be updated. +!!! \ No newline at end of file From 8efc98862cc39c4f8410e0c40d8f1871a11ba737 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 12 Mar 2024 14:35:21 -0400 Subject: [PATCH 158/176] Adding Adam's Imaging Data Document to the specific assay page. --- data_model/data_standards.md | 2 +- data_pub_submission/specific_details.md | 8 +++----- 2 files changed, 4 insertions(+), 6 deletions(-) diff --git a/data_model/data_standards.md b/data_model/data_standards.md index cf3077b0..1abb41e1 100644 --- a/data_model/data_standards.md +++ b/data_model/data_standards.md @@ -4,7 +4,7 @@ order: 997 # Data Standards -This page is a place holder for data standards page/set of data standards pages similar to [MC2 Center Data Model](https://mc2-center.github.io/data-models/). The HTAN version of the MCS tables will include additional columns such as "required_if_component" and "required_if_value". See [data-models issue#354](https://github.com/ncihtan/data-models/issues/354) for more information. +This page is a place holder for data standards page/set of data standards pages similar to [MC2 Center Data Model](https://mc2-center.github.io/data-models/). The HTAN version of the MC2 tables will include additional columns such as "required_if_component" and "required_if_value". See [data-models issue#354](https://github.com/ncihtan/data-models/issues/354) for more information. !!! Note Once these pages are added, the [Data Standards](https://humantumoratlas.org/standards) page will be removed from the data portal. All links to "Data Standards" throughout this manual will need to be updated. diff --git a/data_pub_submission/specific_details.md b/data_pub_submission/specific_details.md index 0a426614..7d57be4a 100644 --- a/data_pub_submission/specific_details.md +++ b/data_pub_submission/specific_details.md @@ -8,21 +8,19 @@ Please see [Data Standards](https://data.humantumoratlas.org/standards) for an o !!! under development. :construction: Please see Sequencing Data and Accessory Files below for example google docs with specific submission details. - -:eyes: Note this page demonstrates a different way to embed links where the url is included and links open in a separate tab. !!! -[!ref target="blank" text="Accessory Files"](https://docs.google.com/document/d/1pCzpf1s7Oh91V9tIwTovvrQfBWRnUJHqe1XBz3K8NfM/edit?usp=sharing) +[Accessory Files](https://docs.google.com/document/d/1pCzpf1s7Oh91V9tIwTovvrQfBWRnUJHqe1XBz3K8NfM/edit?usp=sharing) Biospecimen Clinical Data -Imaging +[Imaging](https://docs.google.com/document/d/1iNicigsSytekEQLkmeNJd2NOJ9VTKzBDfYj3BmvGcro/edit#heading=h.b6j67xcu50c2) RPPR -[!ref target="blank" text="Sequencing Data"](https://docs.google.com/document/d/1IvK3LIFYqUcDb1YrBUFXvKZWmhdJl2m9Oa6LHDOPdcE/edit?usp=sharing) +[equencing Data](https://docs.google.com/document/d/1IvK3LIFYqUcDb1YrBUFXvKZWmhdJl2m9Oa6LHDOPdcE/edit?usp=sharing) Spatial Transcriptomics From c52f5714e4ef80492e779bdd04c3dcddf8137ff3 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Tue, 12 Mar 2024 14:37:39 -0400 Subject: [PATCH 159/176] minor grammar edits --- data_model/data_standards.md | 2 +- data_pub_submission/specific_details.md | 2 +- 2 files changed, 2 insertions(+), 2 deletions(-) diff --git a/data_model/data_standards.md b/data_model/data_standards.md index 1abb41e1..9f19d960 100644 --- a/data_model/data_standards.md +++ b/data_model/data_standards.md @@ -4,7 +4,7 @@ order: 997 # Data Standards -This page is a place holder for data standards page/set of data standards pages similar to [MC2 Center Data Model](https://mc2-center.github.io/data-models/). The HTAN version of the MC2 tables will include additional columns such as "required_if_component" and "required_if_value". See [data-models issue#354](https://github.com/ncihtan/data-models/issues/354) for more information. +This page is a place holder for a data standards page/set of data standards pages similar to [MC2 Center Data Model](https://mc2-center.github.io/data-models/). The HTAN version of the MC2 tables will include additional columns such as "required_if_component" and "required_if_value". See [data-models issue#354](https://github.com/ncihtan/data-models/issues/354) for more information. !!! Note Once these pages are added, the [Data Standards](https://humantumoratlas.org/standards) page will be removed from the data portal. All links to "Data Standards" throughout this manual will need to be updated. diff --git a/data_pub_submission/specific_details.md b/data_pub_submission/specific_details.md index 7d57be4a..e510039b 100644 --- a/data_pub_submission/specific_details.md +++ b/data_pub_submission/specific_details.md @@ -20,7 +20,7 @@ Clinical Data RPPR -[equencing Data](https://docs.google.com/document/d/1IvK3LIFYqUcDb1YrBUFXvKZWmhdJl2m9Oa6LHDOPdcE/edit?usp=sharing) +[Sequencing Data](https://docs.google.com/document/d/1IvK3LIFYqUcDb1YrBUFXvKZWmhdJl2m9Oa6LHDOPdcE/edit?usp=sharing) Spatial Transcriptomics From 811f9ae8caaf392536d5920c81ebe754b7907567 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Mon, 25 Mar 2024 11:31:11 -0400 Subject: [PATCH 160/176] chg to overview to remove publications info. --- .../Data_Deidentification.md | 0 {data_pub_submission => data_submission}/Data_Liaisons.md | 0 .../Information_New_Centers.md | 0 .../clin_biospec_assay.md | 0 {data_pub_submission => data_submission}/index.yml | 0 {data_pub_submission => data_submission}/metadata.md | 0 {data_pub_submission => data_submission}/overview.md | 6 ++---- {data_pub_submission => data_submission}/publications.md | 0 .../specific_details.md | 0 9 files changed, 2 insertions(+), 4 deletions(-) rename {data_pub_submission => data_submission}/Data_Deidentification.md (100%) rename {data_pub_submission => data_submission}/Data_Liaisons.md (100%) rename {data_pub_submission => data_submission}/Information_New_Centers.md (100%) rename {data_pub_submission => data_submission}/clin_biospec_assay.md (100%) rename {data_pub_submission => data_submission}/index.yml (100%) rename {data_pub_submission => data_submission}/metadata.md (100%) rename {data_pub_submission => data_submission}/overview.md (84%) rename {data_pub_submission => data_submission}/publications.md (100%) rename {data_pub_submission => data_submission}/specific_details.md (100%) diff --git a/data_pub_submission/Data_Deidentification.md b/data_submission/Data_Deidentification.md similarity index 100% rename from data_pub_submission/Data_Deidentification.md rename to data_submission/Data_Deidentification.md diff --git a/data_pub_submission/Data_Liaisons.md b/data_submission/Data_Liaisons.md similarity index 100% rename from data_pub_submission/Data_Liaisons.md rename to data_submission/Data_Liaisons.md diff --git a/data_pub_submission/Information_New_Centers.md b/data_submission/Information_New_Centers.md similarity index 100% rename from data_pub_submission/Information_New_Centers.md rename to data_submission/Information_New_Centers.md diff --git a/data_pub_submission/clin_biospec_assay.md b/data_submission/clin_biospec_assay.md similarity index 100% rename from data_pub_submission/clin_biospec_assay.md rename to data_submission/clin_biospec_assay.md diff --git a/data_pub_submission/index.yml b/data_submission/index.yml similarity index 100% rename from data_pub_submission/index.yml rename to data_submission/index.yml diff --git a/data_pub_submission/metadata.md b/data_submission/metadata.md similarity index 100% rename from data_pub_submission/metadata.md rename to data_submission/metadata.md diff --git a/data_pub_submission/overview.md b/data_submission/overview.md similarity index 84% rename from data_pub_submission/overview.md rename to data_submission/overview.md index 1774dd46..0d6e1f8b 100644 --- a/data_pub_submission/overview.md +++ b/data_submission/overview.md @@ -2,7 +2,7 @@ order: 1000 --- -# Data and Publication Submission Overview +# Data Submission Overview Only HTAN Centers and Associate Members can submit data to the HTAN Network's repositories. The Data Submission Section of this Manual is intended as a guide for HTAN Centers and Associate Members. :exclamation: *Prior to submitting data, all data must be de-identified. Please see [Data De-identification](../data_pub_submission/Data_Deidentification.md) for more information.* @@ -11,10 +11,8 @@ Data Submission involves two key steps: 1. Uploading assay data files to Synapse; and 2. Completing and validating manifests using the Data Curator App (DCA). -HTAN-associated publications are also submitted by completing and validating a manifest using the DCA. - ![Data and Publication Submission Overview](../img/Data_Pub_Overview.svg) -Specific details regarding data submission and the DCA are included in later sections of this manual. Please contact your [Data Liaison](../data_pub_submission/Data_Liaisons.md) if you have any questions or issues. Please also keep your data liaison informed of any data or publication submissions. +Specific details regarding data submission and the DCA are included in later sections of this manual. Please contact your [Data Liaison](../data_pub_submission/Data_Liaisons.md) if you have any questions or issues. Please also keep your data liaison informed of any data submissions. The current status of data uploads (refreshed every 4 hours) is available on the [HTAN Dashboard](http://hdash.website-us-east-1.linodeobjects.com/index.html). \ No newline at end of file diff --git a/data_pub_submission/publications.md b/data_submission/publications.md similarity index 100% rename from data_pub_submission/publications.md rename to data_submission/publications.md diff --git a/data_pub_submission/specific_details.md b/data_submission/specific_details.md similarity index 100% rename from data_pub_submission/specific_details.md rename to data_submission/specific_details.md From ab50c4056f60f822b58775765a93341acde299d9 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Mon, 25 Mar 2024 11:34:11 -0400 Subject: [PATCH 161/176] Modified Data Submit overview svg --- .DS_Store | Bin 10244 -> 8196 bytes data_submission/overview.md | 2 +- img/Data_Submit_Overview.svg | 1 + 3 files changed, 2 insertions(+), 1 deletion(-) create mode 100644 img/Data_Submit_Overview.svg diff --git a/.DS_Store b/.DS_Store index ba216ab66907c659e2e57f8360e9be9f64872859..a7022222d730546ddf11272023aeee6cd3d3db52 100644 GIT binary patch delta 112 zcmZn(XmOBWU|?W$DortDU;r^WfEYvza8E20o2aMA$hI+HH$NlWW*z}{#>wVF9c<>N zItnHhlMf0yY-SZ!V-sWsss;iHZXn?b(zvnkJM(0Il|T+gh;a;)<9TLmRuN-i1^`RF B6Nmr+ delta 217 zcmZp1XbF&DU|?W$DortDU{C-uIe-{M3-C-V6q~50$jGrVU^hP_$7UV@c1Cq!h7^WG zh7ur-XDDDOWk>?j#b7#@Arr_d29o&R diff --git a/data_submission/overview.md b/data_submission/overview.md index 0d6e1f8b..91287fab 100644 --- a/data_submission/overview.md +++ b/data_submission/overview.md @@ -11,7 +11,7 @@ Data Submission involves two key steps: 1. Uploading assay data files to Synapse; and 2. Completing and validating manifests using the Data Curator App (DCA). -![Data and Publication Submission Overview](../img/Data_Pub_Overview.svg) +![Data and Publication Submission Overview](../img/Data_Submit_Overview.svg) Specific details regarding data submission and the DCA are included in later sections of this manual. Please contact your [Data Liaison](../data_pub_submission/Data_Liaisons.md) if you have any questions or issues. Please also keep your data liaison informed of any data submissions. diff --git a/img/Data_Submit_Overview.svg b/img/Data_Submit_Overview.svg new file mode 100644 index 00000000..39d5aedf --- /dev/null +++ b/img/Data_Submit_Overview.svg @@ -0,0 +1 @@ + \ No newline at end of file From 6f77511588d3258bc00112b273cca57169dec083 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Mon, 25 Mar 2024 11:45:57 -0400 Subject: [PATCH 162/176] moving publications info to addnt'l info, adding alex's contact info. --- addtnl_info/RFC.md | 2 +- addtnl_info/WG_internal.md | 2 +- addtnl_info/data_release.md | 2 +- addtnl_info/publications.md | 12 ++++++++++++ addtnl_info/tnps.md | 2 +- data_submission/publications.md | 14 -------------- 6 files changed, 16 insertions(+), 18 deletions(-) create mode 100644 addtnl_info/publications.md delete mode 100644 data_submission/publications.md diff --git a/addtnl_info/RFC.md b/addtnl_info/RFC.md index f50cd2eb..1bade23f 100644 --- a/addtnl_info/RFC.md +++ b/addtnl_info/RFC.md @@ -1,5 +1,5 @@ --- -order: 997 +order: 996 --- # The RFC Process and Data Model Changes diff --git a/addtnl_info/WG_internal.md b/addtnl_info/WG_internal.md index 4e921123..1f688a7f 100644 --- a/addtnl_info/WG_internal.md +++ b/addtnl_info/WG_internal.md @@ -1,5 +1,5 @@ --- -order: 998 +order: 997 --- # Working Groups and Internal Communications diff --git a/addtnl_info/data_release.md b/addtnl_info/data_release.md index 468c0512..5571d8e2 100644 --- a/addtnl_info/data_release.md +++ b/addtnl_info/data_release.md @@ -1,5 +1,5 @@ --- -order: 999 +order: 998 --- # Data Release diff --git a/addtnl_info/publications.md b/addtnl_info/publications.md new file mode 100644 index 00000000..8645eabb --- /dev/null +++ b/addtnl_info/publications.md @@ -0,0 +1,12 @@ +--- +order: 999 +--- + +# Submitting Publications + +To facilitate data sharing and adherence to FAIR (Findability, Accessibility, Interoperability, and Reusability) principles, the HTAN portal provides links to specimen files used in publications. Currently, the HTAN Data Coordinating Center (DCC) faciliates this linking once provided the appropriate information by HTAN Centers. To submit publication information, HTAN Center's should contact Alex Lash at alexl@ds.dfci.harvard.edu. + +!!! *In order to support data sharing and public data access, publications should either:* +* *use HTAN identifiers; or* +* *provide a lookup table in the publication to map publication identifiers to HTAN identifiers.* +!!! diff --git a/addtnl_info/tnps.md b/addtnl_info/tnps.md index 2bc1bf0d..82eb2f59 100644 --- a/addtnl_info/tnps.md +++ b/addtnl_info/tnps.md @@ -1,5 +1,5 @@ --- -order: 996 +order: 995 --- # Trans-Network Projects (TNPs) diff --git a/data_submission/publications.md b/data_submission/publications.md deleted file mode 100644 index fa2b02b6..00000000 --- a/data_submission/publications.md +++ /dev/null @@ -1,14 +0,0 @@ ---- -order: 992 ---- - -# Submitting Publications - -Publications are submitted to HTAN via the publications metadata template on Synapse Data Curator App ([DCA](https://dca.app.sagebionetworks.org/)). To access the DCA, you must be a Synapse [certified user](https://help.synapse.org/docs/Synapse-User-Account-Types.2007072795.html). - -The metadata template will facilitate linking a HTAN publication to the specimen and assay files used in the publication. - -!!! *In order to support data sharing and public data access, publications should either:* -* *use HTAN identifiers; or* -* *provide a lookup table in the publication to map publication identifiers to HTAN identifiers.* -!!! From 967ad08c8edbabc3b7e26747d8950a4b4961d1f9 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Mon, 25 Mar 2024 11:48:45 -0400 Subject: [PATCH 163/176] moving publications info to addnt'l info, adding alex's contact info. --- data_submission/index.yml | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data_submission/index.yml b/data_submission/index.yml index e001e21b..fe11ae5d 100644 --- a/data_submission/index.yml +++ b/data_submission/index.yml @@ -1,2 +1,2 @@ -label: Data and Publication Submissions +label: Submitting Data order: 996 From 64d19c326d5d8fb54a2ba962bd92b5e9dc0eafbb Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Mon, 25 Mar 2024 11:49:43 -0400 Subject: [PATCH 164/176] minor text changes --- data_submission/overview.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data_submission/overview.md b/data_submission/overview.md index 91287fab..2107d1b8 100644 --- a/data_submission/overview.md +++ b/data_submission/overview.md @@ -11,7 +11,7 @@ Data Submission involves two key steps: 1. Uploading assay data files to Synapse; and 2. Completing and validating manifests using the Data Curator App (DCA). -![Data and Publication Submission Overview](../img/Data_Submit_Overview.svg) +![Data Submission Overview](../img/Data_Submit_Overview.svg) Specific details regarding data submission and the DCA are included in later sections of this manual. Please contact your [Data Liaison](../data_pub_submission/Data_Liaisons.md) if you have any questions or issues. Please also keep your data liaison informed of any data submissions. From 6330260f9565c309e357c3e2cf2cf2177f902f1d Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Wed, 27 Mar 2024 12:05:13 -0400 Subject: [PATCH 165/176] fixing data submission links --- data_submission/Information_New_Centers.md | 2 +- data_submission/clin_biospec_assay.md | 4 ++-- data_submission/metadata.md | 2 +- data_submission/overview.md | 4 ++-- 4 files changed, 6 insertions(+), 6 deletions(-) diff --git a/data_submission/Information_New_Centers.md b/data_submission/Information_New_Centers.md index 0705e3b8..235bcb93 100644 --- a/data_submission/Information_New_Centers.md +++ b/data_submission/Information_New_Centers.md @@ -10,7 +10,7 @@ The [Resources page](https://humantumoratlas.org/resources) of the HTAN Data Por All HTAN members must have an executed Human Tumor Atlas Network DMSA (Internal Data and Materials Sharing Agreement) [(HTAN DMSA)](https://docs.google.com/document/d/1RPFm9MBJv8DjZmYZyIv0jbjtNJ8fnwGjYDjlK4lL4nc/edit) with Sage Bionetworks prior to contributing data to the HTAN Data Coordinating Center [(DCC)](https://humantumoratlas.org/htan-dcc). To initiate execution of the HTAN DMSA, contact Sage HTAN Governance (htan@sagebionetworks.jira.com). Please include the name and contact information of your HTAN PI and Institution Signatory to enable routing the HTAN DMSA for execution. -HTAN Centers are assigned a [data liaison](../data_pub_submission/Data_Liaisons.md) from the [(DCC)](https://humantumoratlas.org/htan-dcc). Trans-Network Projects (TNPs) are also assigned liaisons. Your liaison will help guide you through setting up a new atlas or project, creating HTAN identifiers, and submitting metadata and data files. Please keep your liaison informed of publications timelines and new data submissions. +HTAN Centers are assigned a [data liaison](../data_submission/Data_Liaisons.md) from the [(DCC)](https://humantumoratlas.org/htan-dcc). Trans-Network Projects (TNPs) are also assigned liaisons. Your liaison will help guide you through setting up a new atlas or project, creating HTAN identifiers, and submitting metadata and data files. Please keep your liaison informed of publications timelines and new data submissions. Please see the appropriate page of this manual for additional details about HTAN center responsibilities for data de-identification, including submitting a data de-identification plan, and specific instructions regarding how to submit data. Clinical, biospecimen, and assay data submitted to the DCC are distributed to repositories based on access levels. Information regarding how data are accessed by external users is described more in [other parts of this manual](../overview/data_levels.md). diff --git a/data_submission/clin_biospec_assay.md b/data_submission/clin_biospec_assay.md index 1a98a3e9..69142e76 100644 --- a/data_submission/clin_biospec_assay.md +++ b/data_submission/clin_biospec_assay.md @@ -4,7 +4,7 @@ order: 995 # Submitting Assay Data and Metadata -As stated in [Data and Publication Submission Overview](../data_pub_submission/overview.md), data submission involves two key steps: +As stated in [Data and Publication Submission Overview](../data_submission/overview.md), data submission involves two key steps: 1. Uploading assay data files to Synapse; and 2. Completing and validating metadata using the Data Curator App (DCA). @@ -29,7 +29,7 @@ To upload files to the Synapse Platform, you need to be a [Synapse Certified Use ## Contact your Data Liaison to set up your project and cloud bucket. -When you are ready to upload data, please contact your [data liaison](../data_pub_submission/Data_Liaisons.md). Your data liaison will need to know: +When you are ready to upload data, please contact your [data liaison](../data_submission/Data_Liaisons.md). Your data liaison will need to know: 1. Your centers 2. Who on your team will be doing the data upload. 3. The synapse usernames for team members identified in #2. diff --git a/data_submission/metadata.md b/data_submission/metadata.md index 41facba0..159ef728 100644 --- a/data_submission/metadata.md +++ b/data_submission/metadata.md @@ -10,7 +10,7 @@ Metadata means data *about* data. Metadata enables both data searchability and HTAN's [Data Model](../data_model/overview.md) is a framework for collecting and storing metadata. The Data Model in turn supports effective searching for data on [HTAN's Data Portal](https://humantumoratlas.org/explore). -Metadata is submitted to HTAN via the Synapse Data Curator App [(DCA)](https://dca.app.sagebionetworks.org/), developed and maintained by [Sage Bionetworks](https://sagebionetworks.org/). The DCA performs several automated validation checks to make sure the metadata complies with the HTAN Data Model. Please see [Submitting Data Files and Metadata](../data_pub_submission/clin_biospec_assay.md) for more information about the DCA. +Metadata is submitted to HTAN via the Synapse Data Curator App [(DCA)](https://dca.app.sagebionetworks.org/), developed and maintained by [Sage Bionetworks](https://sagebionetworks.org/). The DCA performs several automated validation checks to make sure the metadata complies with the HTAN Data Model. Please see [Submitting Data Files and Metadata](../data_submission/clin_biospec_assay.md) for more information about the DCA. !!! Terminology Alert The term "manifests" refers to the spreadsheets used to submit metadata. "Metadata templates" are available via the DCA. These are manifests which can be filled out, validated and submitted using the DCA's web interface. diff --git a/data_submission/overview.md b/data_submission/overview.md index 2107d1b8..86a53ffc 100644 --- a/data_submission/overview.md +++ b/data_submission/overview.md @@ -5,7 +5,7 @@ order: 1000 # Data Submission Overview Only HTAN Centers and Associate Members can submit data to the HTAN Network's repositories. The Data Submission Section of this Manual is intended as a guide for HTAN Centers and Associate Members. -:exclamation: *Prior to submitting data, all data must be de-identified. Please see [Data De-identification](../data_pub_submission/Data_Deidentification.md) for more information.* +:exclamation: *Prior to submitting data, all data must be de-identified. Please see [Data De-identification](../data_submission/Data_Deidentification.md) for more information.* Data Submission involves two key steps: 1. Uploading assay data files to Synapse; and @@ -13,6 +13,6 @@ Data Submission involves two key steps: ![Data Submission Overview](../img/Data_Submit_Overview.svg) -Specific details regarding data submission and the DCA are included in later sections of this manual. Please contact your [Data Liaison](../data_pub_submission/Data_Liaisons.md) if you have any questions or issues. Please also keep your data liaison informed of any data submissions. +Specific details regarding data submission and the DCA are included in later sections of this manual. Please contact your [Data Liaison](../data_submission/Data_Liaisons.md) if you have any questions or issues. Please also keep your data liaison informed of any data submissions. The current status of data uploads (refreshed every 4 hours) is available on the [HTAN Dashboard](http://hdash.website-us-east-1.linodeobjects.com/index.html). \ No newline at end of file From beeeaef6aadcde4153e2f30ac38460f82a91eaf3 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Wed, 27 Mar 2024 15:35:42 -0400 Subject: [PATCH 166/176] final edits for potential merge to main 4/1/2024 --- data_model/data_standards.md | 2 +- data_submission/specific_details.md | 6 +++--- readme.md | 4 +++- 3 files changed, 7 insertions(+), 5 deletions(-) diff --git a/data_model/data_standards.md b/data_model/data_standards.md index 9f19d960..1c1ef570 100644 --- a/data_model/data_standards.md +++ b/data_model/data_standards.md @@ -4,7 +4,7 @@ order: 997 # Data Standards -This page is a place holder for a data standards page/set of data standards pages similar to [MC2 Center Data Model](https://mc2-center.github.io/data-models/). The HTAN version of the MC2 tables will include additional columns such as "required_if_component" and "required_if_value". See [data-models issue#354](https://github.com/ncihtan/data-models/issues/354) for more information. +This page is a place holder for a data standards page/set of data standards pages similar to [MC2 Center Data Model](https://mc2-center.github.io/data-models/). The HTAN version of the MC2 tables will include additional columns such as "required_if_component" and "required_if_value". Until the new pages are constructed, please see the information on the [Data Standards](https://humantumoratlas.org/standards) page of the HTAN Data Portal. !!! Note Once these pages are added, the [Data Standards](https://humantumoratlas.org/standards) page will be removed from the data portal. All links to "Data Standards" throughout this manual will need to be updated. diff --git a/data_submission/specific_details.md b/data_submission/specific_details.md index e510039b..b3858428 100644 --- a/data_submission/specific_details.md +++ b/data_submission/specific_details.md @@ -7,10 +7,10 @@ order: 993 Please see [Data Standards](https://data.humantumoratlas.org/standards) for an overview of HTAN Data Levels and Metadata Attributes for each data type. The following links provide specific submission details for each data type. !!! under development. -:construction: Please see Sequencing Data and Accessory Files below for example google docs with specific submission details. +:construction: Currently this page contains additional information regarding Imaging data. The Data Coordinating Center (DCC) plans to develop additional documents which will be linked from this page at a later time. !!! -[Accessory Files](https://docs.google.com/document/d/1pCzpf1s7Oh91V9tIwTovvrQfBWRnUJHqe1XBz3K8NfM/edit?usp=sharing) +Accessory Files Biospecimen @@ -20,7 +20,7 @@ Clinical Data RPPR -[Sequencing Data](https://docs.google.com/document/d/1IvK3LIFYqUcDb1YrBUFXvKZWmhdJl2m9Oa6LHDOPdcE/edit?usp=sharing) +Sequencing Data Spatial Transcriptomics diff --git a/readme.md b/readme.md index 9018c210..a3729ede 100644 --- a/readme.md +++ b/readme.md @@ -8,11 +8,13 @@ Written by the HTAN Data Coordinating Center (DCC), with contributions from Adam The manual can be found at https://docs.humantumoratlas.org/. +If you have feedback for this manual, including broken links or incorrect information, please submit a ticket to the [HTAN Help Desk](https://sagebionetworks.jira.com/servicedesk/customer/portal/1) + ## Content Updates | Date | Comment | Changes summary | |------------|--------------------------|-----------------| -| :exclamation::exclamation: | Third version of manual | Simplified Data Model section; added "Data Publication Submissions" and "Additional Information" Sections | +| 2024-04-01 | Third version of manual | Simplified Data Model section; added "Submitting Data" and "Additional Information" Sections | | 2023-06-01 | Second version of manual | | | 2022-09-28 | First version of manual | | From e5c47d9820153b7c9e844dfa0398bcade244de46 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Wed, 27 Mar 2024 15:38:19 -0400 Subject: [PATCH 167/176] add jen as author --- readme.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/readme.md b/readme.md index a3729ede..29c3b36b 100644 --- a/readme.md +++ b/readme.md @@ -1,6 +1,6 @@ # The HTAN Manual -Written by the HTAN Data Coordinating Center (DCC), with contributions from Adam Taylor, Clarisse Lau, Vésteinn Thorsson, Ino de Bruijn, David Gibbs, Ethan Cerami and Alex Lash. +Written by the HTAN Data Coordinating Center (DCC), with contributions from Adam Taylor, Clarisse Lau, Vésteinn Thorsson, Ino de Bruijn, David Gibbs, Ethan Cerami, Alex Lash and Jen Altreuter. ## About this Manual From d0abf5d9b6742f4de67fbb6cbcd770ef423f3291 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Wed, 27 Mar 2024 15:39:44 -0400 Subject: [PATCH 168/176] changed PCAPP liaison to jen. --- data_submission/Data_Liaisons.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/data_submission/Data_Liaisons.md b/data_submission/Data_Liaisons.md index 09130bfe..ee495707 100644 --- a/data_submission/Data_Liaisons.md +++ b/data_submission/Data_Liaisons.md @@ -11,7 +11,7 @@ Here is the current list of centers, their atlases and DCC liaisons: | Atlas | Atlas ID | Liaison | Email | |-------|----------|---------|-------| | PILOT - HTAPP | HTA1 | Vesteinn Thorsson | thorsson@isbscience.org | -| PILOT - PCAPP | HTA2 | Ethan Cerami | cerami@ds.dfci.harvard.edu | +| PILOT - PCAPP | HTA2 | Jennifer Altreuter | jennifer@ds.dfci.harvard.edu | | HTAN BU | HTA3 | Jennifer Altreuter | jennifer@ds.dfci.harvard.edu | | HTAN CHOP | HTA4 | Ino de Bruijn | debruiji@mskcc.org | | HTAN DFCI | HTA5 | Jennifer Altreuter | jennifer@ds.dfci.harvard.edu | From 9daed0552231e436ac825974d85bdeb00d279096 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Wed, 27 Mar 2024 16:03:31 -0400 Subject: [PATCH 169/176] remove some of the data model change language from the RFC page. --- addtnl_info/RFC.md | 12 ++---------- data_submission/clin_biospec_assay.md | 2 +- data_submission/metadata.md | 2 +- data_submission/specific_details.md | 2 +- 4 files changed, 5 insertions(+), 13 deletions(-) diff --git a/addtnl_info/RFC.md b/addtnl_info/RFC.md index 1bade23f..35e95918 100644 --- a/addtnl_info/RFC.md +++ b/addtnl_info/RFC.md @@ -18,22 +18,14 @@ The links to specific RFC documents within the RFC Overview do **not** represent !!! ## Data Model Changes -New assays or data types do not always require data model changes and an RFC. - -The following generally do not require a change to the Data Model: - -- New assays which are specific to only one center or will only be used in a limited capacity. These can often be accommodated as “Other Assay”. -- Additional free text metadata fields. Additional columns can be added to your copy of the metadata template if they do not require validation by the Data Curator App. - -The following require changes to the Data Model and would need to undergo the Request for Comments (RFC) process: +The following are requests which require changes to the Data Model and may result in the initiation of a RFC: - New assay types which are expected to be used frequently by multiple centers. - New metadata templates or additional required metadata fields which should be validated. -Please contact your [data liaison](../data_pub_submission/Data_Liaisons.md) for help determining whether a Data Model change is needed and how to make a Data Model change request. +Please contact your [data liaison](../data_pub_submission/Data_Liaisons.md) for help determining whether a Data Model change is needed and how to make a Data Model change request. ## RFC Process - Once a new assay type or a set of needed Data Model changes are identified, the following steps are taken: 1. **A working group is organized** by the Data Coordinating Center (DCC). As a part of this process, the following people are also designated: diff --git a/data_submission/clin_biospec_assay.md b/data_submission/clin_biospec_assay.md index 69142e76..a2b16153 100644 --- a/data_submission/clin_biospec_assay.md +++ b/data_submission/clin_biospec_assay.md @@ -4,7 +4,7 @@ order: 995 # Submitting Assay Data and Metadata -As stated in [Data and Publication Submission Overview](../data_submission/overview.md), data submission involves two key steps: +As stated in [Data Submission Overview](../data_submission/overview.md), data submission involves two key steps: 1. Uploading assay data files to Synapse; and 2. Completing and validating metadata using the Data Curator App (DCA). diff --git a/data_submission/metadata.md b/data_submission/metadata.md index 159ef728..cd6cd3c7 100644 --- a/data_submission/metadata.md +++ b/data_submission/metadata.md @@ -10,7 +10,7 @@ Metadata means data *about* data. Metadata enables both data searchability and HTAN's [Data Model](../data_model/overview.md) is a framework for collecting and storing metadata. The Data Model in turn supports effective searching for data on [HTAN's Data Portal](https://humantumoratlas.org/explore). -Metadata is submitted to HTAN via the Synapse Data Curator App [(DCA)](https://dca.app.sagebionetworks.org/), developed and maintained by [Sage Bionetworks](https://sagebionetworks.org/). The DCA performs several automated validation checks to make sure the metadata complies with the HTAN Data Model. Please see [Submitting Data Files and Metadata](../data_submission/clin_biospec_assay.md) for more information about the DCA. +Metadata is submitted to HTAN via the Synapse Data Curator App [(DCA)](https://dca.app.sagebionetworks.org/), developed and maintained by [Sage Bionetworks](https://sagebionetworks.org/). The DCA performs several automated validation checks to make sure the metadata complies with the HTAN Data Model. Please see [Submitting Assay Data and Metadata](../data_submission/clin_biospec_assay.md) for more information about the DCA. !!! Terminology Alert The term "manifests" refers to the spreadsheets used to submit metadata. "Metadata templates" are available via the DCA. These are manifests which can be filled out, validated and submitted using the DCA's web interface. diff --git a/data_submission/specific_details.md b/data_submission/specific_details.md index b3858428..c1433d8a 100644 --- a/data_submission/specific_details.md +++ b/data_submission/specific_details.md @@ -7,7 +7,7 @@ order: 993 Please see [Data Standards](https://data.humantumoratlas.org/standards) for an overview of HTAN Data Levels and Metadata Attributes for each data type. The following links provide specific submission details for each data type. !!! under development. -:construction: Currently this page contains additional information regarding Imaging data. The Data Coordinating Center (DCC) plans to develop additional documents which will be linked from this page at a later time. +:construction: Currently this page contains additional information for Imaging data. The Data Coordinating Center (DCC) plans to develop additional documents which will be linked from this page at a later time. !!! Accessory Files From 10fa20fd176f430901cb3af2f1b76666d4e61975 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Wed, 27 Mar 2024 16:04:52 -0400 Subject: [PATCH 170/176] Minor grammar edits, TNP page. --- addtnl_info/tnps.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/addtnl_info/tnps.md b/addtnl_info/tnps.md index 82eb2f59..00d08e81 100644 --- a/addtnl_info/tnps.md +++ b/addtnl_info/tnps.md @@ -3,7 +3,7 @@ order: 995 --- # Trans-Network Projects (TNPs) -Trans-Network Projects are multi-center projects created to facilitate collaborative research, such as cross-testing of experimental and analytical protocols, exchange of personnel to disseminate SOPs, or pursuit of additional HTAN critical methods or technologies. Specific information about each TNP is available on [HTAN's Synapse Wiki page](https://www.synapse.org/#!Synapse:syn17022193/wiki/584990) for HTAN members. +Trans-Network Projects are multi-center projects created to facilitate collaborative research. Examples include cross-testing experimental and analytical protocols, exchange of personnel to disseminate SOPs or pursuit of additional HTAN critical methods or technologies. Specific information about each TNP is available on [HTAN's Synapse Wiki page](https://www.synapse.org/#!Synapse:syn17022193/wiki/584990) for HTAN members. !!! Note From 0e35e675e271744f36fd3c0c75c3a82d6d1b3cba Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Wed, 27 Mar 2024 16:06:43 -0400 Subject: [PATCH 171/176] fix link, RFC page. --- addtnl_info/RFC.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/addtnl_info/RFC.md b/addtnl_info/RFC.md index 35e95918..0f9fe371 100644 --- a/addtnl_info/RFC.md +++ b/addtnl_info/RFC.md @@ -23,7 +23,7 @@ The following are requests which require changes to the Data Model and may resul - New assay types which are expected to be used frequently by multiple centers. - New metadata templates or additional required metadata fields which should be validated. -Please contact your [data liaison](../data_pub_submission/Data_Liaisons.md) for help determining whether a Data Model change is needed and how to make a Data Model change request. +Please contact your [data liaison](../data_submission/Data_Liaisons.md) for help determining whether a Data Model change is needed and how to make a Data Model change request. ## RFC Process Once a new assay type or a set of needed Data Model changes are identified, the following steps are taken: From 49693fd7125f5bc3f22598856b950460dfaba9bb Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Wed, 27 Mar 2024 16:09:40 -0400 Subject: [PATCH 172/176] missing period --- readme.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/readme.md b/readme.md index 29c3b36b..483b80ab 100644 --- a/readme.md +++ b/readme.md @@ -8,7 +8,7 @@ Written by the HTAN Data Coordinating Center (DCC), with contributions from Adam The manual can be found at https://docs.humantumoratlas.org/. -If you have feedback for this manual, including broken links or incorrect information, please submit a ticket to the [HTAN Help Desk](https://sagebionetworks.jira.com/servicedesk/customer/portal/1) +If you have feedback for this manual, including broken links or incorrect information, please submit a ticket to the [HTAN Help Desk](https://sagebionetworks.jira.com/servicedesk/customer/portal/1). ## Content Updates From ac17f636a479840423688ddb76557c44ee7795db Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 29 Mar 2024 12:48:47 -0400 Subject: [PATCH 173/176] changing contact on main readme --- readme.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/readme.md b/readme.md index 483b80ab..b75c58db 100644 --- a/readme.md +++ b/readme.md @@ -4,7 +4,7 @@ Written by the HTAN Data Coordinating Center (DCC), with contributions from Adam ## About this Manual -**The HTAN Manual** provides an overview of Human Tumor Atlas Network (HTAN) data, including the various levels of data access. If you have any questions regarding the manual or HTAN data, please contact us at: htan@googlegroups.com. +**The HTAN Manual** provides an overview of Human Tumor Atlas Network (HTAN) data, including the various levels of data access. If you have any questions regarding the manual or HTAN data, please contact us: [HTAN Help Desk](https://sagebionetworks.jira.com/servicedesk/customer/portal/1). The manual can be found at https://docs.humantumoratlas.org/. From aa93bb164acfc17341565decfdf7db247ca5c251 Mon Sep 17 00:00:00 2001 From: Jennifer Altreuter Date: Fri, 29 Mar 2024 15:17:37 -0400 Subject: [PATCH 174/176] Additional edits from Alex. --- access_controlled/introduction.md | 2 +- data_model/identifiers.md | 3 +++ open_access/introduction.md | 4 +--- overview/centers.md | 2 +- overview/introduction.md | 2 +- 5 files changed, 7 insertions(+), 6 deletions(-) diff --git a/access_controlled/introduction.md b/access_controlled/introduction.md index 41144ff1..a1827f3b 100644 --- a/access_controlled/introduction.md +++ b/access_controlled/introduction.md @@ -4,4 +4,4 @@ order: 1000 # Access-Controlled Data -Access-controlled HTAN data requires dbGaP access approval for study [phs002371](https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs002371.v3.p1), and is currently only available via the National Cancer Institute's Cancer Data Services (CDS). +Access-controlled HTAN data requires dbGaP access approval for study [phs002371](https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs002371.v3.p1), and is currently only available via the [National Cancer Institute's Cancer Data Services (CDS)](https://dataservice.datacommons.cancer.gov/#/home). diff --git a/data_model/identifiers.md b/data_model/identifiers.md index a7356d71..e0e5b2ef 100644 --- a/data_model/identifiers.md +++ b/data_model/identifiers.md @@ -31,6 +31,7 @@ HTA4_1_1 HTA4_1_3 HTA4_1_8 ``` +## Special Identifiers If a single data file is generated from one of those samples, that file could have an HTAN ID such as: @@ -56,4 +57,6 @@ HTA4_EXT3_3 More detailed information about HTAN Identifiers may be found in the [HTAN Identifiers SOP](https://docs.google.com/document/d/1podtPP8L1UNvVxx9_c_szlDcU1f8n7bige6XA_GoRVM/edit#heading=h.768a6pngjha3). +## ID to ID linkages + Note that the explicit linking of participants to biospecimens to assays is not encoded in the HTAN Identifier. Rather, the linking is encoded in explicit metadata elements (see [Relationship Model](relationships.md)). diff --git a/open_access/introduction.md b/open_access/introduction.md index 8f07601f..75e7f9dd 100644 --- a/open_access/introduction.md +++ b/open_access/introduction.md @@ -6,13 +6,11 @@ order: 1000 The [HTAN Data Portal](https://humantumoratlas.org/explore) provides an overview of all released data. For Open Access data, the Portal also provides links to: - downloadable files on Synapse; -- CellxGene for visualization of single cell RNA-sequencing data; +- CellxGene and Xena for visualization of single cell RNA-sequencing data; - Minerva rendered images and stories; - Google BigQuery tables; and - cBioPortal. -Open Access Images can be accessed and downloaded from the NCI's Image Data Commons [(IDC)](https://portal.imaging.datacommons.cancer.gov/) as well as Seven Bridges-Cancer Genomic Cloud [(SB-CGC)](https://cgc-accounts.sbgenomics.com/). - Google BigQuery tables provide direct access to a subset of assay data (mainly level 4 files) on a cloud platform. The Google BigQuery tables provide an easy way to build cohorts using specific data fields. HTAN also provides sample code for working with the data in Google BigQuery. !!! For more detailed information about the HTAN Portal, CellxGene, Minerva-rendered Images, accessing Images via SB-CGC and/or Using Google BigQuery, please see the next sections of this manual. diff --git a/overview/centers.md b/overview/centers.md index 9e1244b3..c3bc3082 100644 --- a/overview/centers.md +++ b/overview/centers.md @@ -4,7 +4,7 @@ order: 999 # HTAN Centers -The HTAN Network consists of ten research centers, and two pilot projects. We also run multiple trans-network projects, referred to as TNPs. Each research center or TNP Project is identified with a unique HTAN prefix. +HTAN currently consists of ten research centers, and two pilot projects. There are also multiple trans-network projects, referred to as TNPs. Each research center or TNP Project is identified with a unique HTAN prefix. | Prefix | Contact Institution or Project Name | Atlas Type | Area of Focus | | ------ | --------------------------------------- | ---------------- | --------------------------------- | diff --git a/overview/introduction.md b/overview/introduction.md index 7f6dba1e..cc778cf5 100644 --- a/overview/introduction.md +++ b/overview/introduction.md @@ -6,7 +6,7 @@ order: 1000 The **Human Tumor Atlas Network (HTAN)** is a National Cancer Institute-funded Cancer Moonshot initiative focused on studying the **transitions of human cancers** as they evolve from **precancerous lesions to advanced disease**. -The network consists of **ten research centers** and a **Data Coordinating Center (DCC)**. Five of the research centers are focused on developing **pre-cancer atlases**, and the remaining five centers are focused on developing **tumor atlases**. We also have two pilot projects, one focused on pre-cancer atlases, and one focused on tumor atlases. +In the current phase of HTAN (phase 1), the network consists of **ten research centers** and a **Data Coordinating Center (DCC)**. Five of the research centers are focused on developing **pre-cancer atlases**, and the remaining five centers are focused on developing **tumor atlases**. We also have two pilot projects, one focused on pre-cancer atlases, and one focused on tumor atlases. Each research center is responsible for gathering and processing samples, and running their own experimental assays. Assays vary by center, but most centers have a strong focus on **single cell RNA-Seq** and a wide range of **multiplex imaging modalities**. From efe3145b85a4cf4dbfde446e4373dcded20deeb2 Mon Sep 17 00:00:00 2001 From: jen-dfci <77687519+jen-dfci@users.noreply.github.com> Date: Mon, 1 Apr 2024 15:54:59 -0400 Subject: [PATCH 175/176] Update RFC.md Changed working to "HTAN members should contact their data liaison..." --- addtnl_info/RFC.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/addtnl_info/RFC.md b/addtnl_info/RFC.md index 0f9fe371..f5fac306 100644 --- a/addtnl_info/RFC.md +++ b/addtnl_info/RFC.md @@ -23,7 +23,7 @@ The following are requests which require changes to the Data Model and may resul - New assay types which are expected to be used frequently by multiple centers. - New metadata templates or additional required metadata fields which should be validated. -Please contact your [data liaison](../data_submission/Data_Liaisons.md) for help determining whether a Data Model change is needed and how to make a Data Model change request. +HTAN members should contact their [data liaison](../data_submission/Data_Liaisons.md) for help determining whether a Data Model change is needed and how to make a Data Model change request. ## RFC Process Once a new assay type or a set of needed Data Model changes are identified, the following steps are taken: From 9bea96bc51143f7967de249c26b104896925f048 Mon Sep 17 00:00:00 2001 From: jen-dfci <77687519+jen-dfci@users.noreply.github.com> Date: Mon, 1 Apr 2024 16:07:16 -0400 Subject: [PATCH 176/176] Update publications.md updating language re: HTAN identifiers in publications --- addtnl_info/publications.md | 6 +++--- 1 file changed, 3 insertions(+), 3 deletions(-) diff --git a/addtnl_info/publications.md b/addtnl_info/publications.md index 8645eabb..f3b038ae 100644 --- a/addtnl_info/publications.md +++ b/addtnl_info/publications.md @@ -6,7 +6,7 @@ order: 999 To facilitate data sharing and adherence to FAIR (Findability, Accessibility, Interoperability, and Reusability) principles, the HTAN portal provides links to specimen files used in publications. Currently, the HTAN Data Coordinating Center (DCC) faciliates this linking once provided the appropriate information by HTAN Centers. To submit publication information, HTAN Center's should contact Alex Lash at alexl@ds.dfci.harvard.edu. -!!! *In order to support data sharing and public data access, publications should either:* -* *use HTAN identifiers; or* -* *provide a lookup table in the publication to map publication identifiers to HTAN identifiers.* +!!! *In order to support data sharing and public data access, the DCC encourages authors using HTAN data to either:* +* *use HTAN identifiers in their publication; or* +* *provide a lookup table in the publication to map publication identifiers to HTAN identifiers.* !!!

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