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Tools for dynamic dosing with mrgsolve

Poster

Simulating Adaptive Dosing Regimens from PK and PKPD Models Using mrgsolve
15th American Conference on Pharmacometrics
Poster: W-007, Wednesday November 13, 2024
PDF: docs/poster.pdf

More info on evtools in the user guide.

Content in this repository

Platelet PKPD model code and outputs

  • Reference: Fukae M, Baron K, Tachibana M, Mondick J, Shimizu T. Population pharmacokinetics of total and unbound valemetostat and platelet dynamics in healthy volunteers and patients with non-Hodgkin lymphoma. CPT Pharmacometrics Syst Pharmacol. 2024; 13: 1641-1654. doi:10.1002/psp4.13201
  • Main PKPD model file contains both the valemetostat PK model and the platelet dynamic model
  • Code to implement platelet monitoring is a C++ header file that gets included into the PKPD model file
  • A simple demonstration of invoking the platelet model with no dose adjustments; generates poster Figure 2
  • The R code used to generate poster Figure 3

A vignette showing ten examples of dose regimen implementation inside your mrgsolve model

  • The vignette source code is here
  • The full source code for all the models can be found here