azithro.cpp

[PROB]
1: Zhao Q, Tensfeldt TG, Chandra R, Mould DR. Population pharmacokinetics of
azithromycin and chloroquine in healthy adults and paediatric malaria subjects
following oral administration of fixed-dose azithromycin and chloroquine
combination tablets. Malar J. 2014 Jan 29;13:36. doi: 10.1186/1475-2875-13-36.
PubMed PMID: 24472224; PubMed Central PMCID: PMC3909452.

https://malariajournal.biomedcentral.com/articles/10.1186/1475-2875-13-36

[SET] end=10*24, delta=0.1

[PARAM] @annotated
TVCL :   100 : Typical value of clearance (L/h)
TVV1 :   186 : Typical central volume of distribution (L)
TVQ2 :   180 : Typical intercomp clearance 1 (L/h)
TVV2 :  2890 : Typical peripheral volume of distribution 1 (L)
Q3   :  10.6 : Intercomp clearance 2 (L/h)
V3   :  2610 : Peripheral volume of distirbution 2 (L)
KA   : 0.259 : Absorption rate constant (1/h)
WT   :    70 : Patient weight (kg)

[CMT] @annotated
GUT  : Dosing compartment (mg)
CENT : Central comaprtment (mg)
PER2 : First peripheral compartment (mg)
PER3 : Second peripheral compartment (mg)
  
[OMEGA] @annotated @block
ETACL : 0.097969 : ETA on clearance
ETAV1 : 0.280000 1.2769 : ETA on V1


[MAIN]
double CL = TVCL*pow(WT/70.0,0.75)*exp(ETACL);
double V1 = TVV1*(WT/70)*exp(ETAV1);
double Q2 = TVQ2*pow(WT/70.0,0.75);
double V2 = TVV2*(WT/70.0);

[SIGMA] @annotated
RUV : 0 : Residual unexplained variability

[ODE]
dxdt_GUT  = -KA*GUT;
dxdt_CENT =  KA*GUT - (CL+Q2+Q3)*CENT/V1 + Q2*PER2/V2 + Q3*PER3/V3;
dxdt_PER2 =  Q2*(CENT/V1 - PER2/V2);
dxdt_PER3 =  Q3*(CENT/V1 - PER3/V3);

[TABLE]
capture CP = CENT/(V1/1000.0)*exp(RUV);