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Can't download jar for eQTL analyzer #660

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BennyStrobes opened this issue Jun 13, 2023 · 6 comments
Open

Can't download jar for eQTL analyzer #660

BennyStrobes opened this issue Jun 13, 2023 · 6 comments

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@BennyStrobes
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I am trying to download the latest build (jar) for the eqtl analyzer code (https://github.com/molgenis/systemsgenetics/wiki/Discovery-of-hidden-confounders-of-QTLs). But the link to the last build does not work. Any help would be greatly appreciated.

@PatrickDeelen
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Thank you for your interest. If you like I can provide a build. However, I would recommend having a look at our most recent and much more advanced effort to identify context dependent effects: https://www.biorxiv.org/content/10.1101/2022.07.28.501849v1

@BennyStrobes
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Hi,

I appreciate you sharing your newer work. Very interesting.

It would be great, though, if you could share the build for the older work.

Ben

@BennyStrobes
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Thanks Patrick. That worked for me. I get an error when I try to run the code on my data. I'm using the following command:
'java -Xmx80g -jar ${proxy_gene_jar_file} -i ${proxy_gene_input_data_dir} -o ${proxy_gene_interaction_eqtl_results_dir} -n 1 -pc 5 -ncn -nt "1"'

I get the following error message.
Screenshot 2023-06-14 at 3 05 08 PM

The data seems to load in fine as it has the correct number of samples, genes, and covariates. Any help would be greatly appreciated? Do you have a working data set/or toy data set that you know works with this code?

@BennyStrobes BennyStrobes reopened this Jun 14, 2023
@BennyStrobes
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Thanks Patrick. That worked for me. I get an error when I try to run the code on my data. I'm using the following command:
'java -Xmx80g -jar ${proxy_gene_jar_file} -i ${proxy_gene_input_data_dir} -o ${proxy_gene_interaction_eqtl_results_dir} -n 1 -pc 5 -ncn -nt "1"'

I get the following error message:
Screenshot 2023-06-14 at 3 05 08 PM

The data seems to load in fine as it has the correct number of samples, genes, and covariates. Any help would be greatly appreciated? Do you have a working data set/or toy data set that you know works with this code?

@PatrickDeelen
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We had a quick look but the old code proved to be a bit of challenge. We stopped using it because with Picalo we now have a much better tool to identify contexts and celltype dependent effects for eQTLs.

Regardless, I understand that you would like to us our published method instead of a preprint. We will have a closer look and hope to get back to you later this week.

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