New term: Mediates binding to fibrinogen in another organism

[genegodbold]

Preferred term label

Mediates binding to fibrinogen in another organism

Textual definition

These gene products mediate attachment to fibrinogen in another organism.

Examples:

• ClfB , Bbp, Eap from Staphylococcus aureus
• DnaK from Mycoplasma pneumoniae: DnaK is a chaperone protein that is sometimes found on the bacterial surface of M. pneumoniae in association with the cell wall, perhaps complexed with the membrane-associated P1 adhesin. Recombinant DnaK can bind to human airway A549 cells and to human plasminogen and to the extracellular matrix proteins vitronectin, fibronectin, fibrinogen, lactoferrin and laminin [PMID28204467].
• EbpA from Enterococcus faecalis: EbpA forms the adhesive tip of the endocarditis and biofilm-associated pilus. These pili are important for binding to host extracellular matrix (ECM) proteins fibrinogen and collagen which is believed critical for the initial stages of colonization [PMID18462135][PMID21505082]. Ebp also play a role in biofilm formation and in animal models of endocarditis [PMID26015496].
• FbsA, PAM, Srr1, Srr2 from Streptococcus
• LigB; OmpL37 from Leptospira
• EcbA, PrpA, Scm from Enterococcus faecium
• SdrG from S. epidermidis: SdrG is an MSCRAMM family adhesin that binds host fibrinogen [PMID14567919].
• Many others...

Suggested parent term

PATHGO:0000038 (mediates adhesion in another organism)

Attribution

https://orcid.org/0000-0002-5702-4690