NTR - metabolism: [U6 snRNA (guanine-N(2))-methyltransferase activity]

[lbreuza]

Please provide as much information as you can:

• Suggested term label:
  U6 snRNA (guanine-N(2))-methyltransferase activity

• ChEBI ID and label of the substance:
  Please ensure that the ChEBI ID corresponds to the physiological form (pH7.3) of the compound. In the ChEBI entry, pH7.3 compounds have a 'UniProt synonym', as in the example for mycophenolate

• Definition (free text)
  Catalysis of the reaction: guanosine in U6 snRNA + S-adenosyl-L-methionine = H+ + N(2)-methylguanosine in U6 snRNA + S-adenosyl-L-homocysteine.

• Reference, in format PMID:#######
  PMID:37283053

• Gene product name and ID to be annotated to this term
  THUMPD2 UniProtKB/Q9BTF0

• Parent term(s)
  GO:0106346 snRNA methyltransferase activity

• Synonym(s) (please specify, EXACT, BROAD, NARROW or RELATED)
  BROAD: U6 snRNA (guanine)-N(2))-methyltransferase activity

• Children terms (if applicable) Should any existing terms that should be moved underneath this new proposed term?

• Cross-references
  Rhea pending

• Any other information

---

• FOR ONTOLOGY EDITOR

• Logical definition

• • substance metabolic process:
    'metabolic process'
    and ('has primary input or output' some [substance]
• • substance biosynthetic process:
    'biosynthetic process'
    and ('has primary output' some [substance].
• • substance catabolic process:
    'catabolic process'
    and ('has primary output' some [substance]

• Standard synonyms

• • substance metabolic process:
• • • EXACT: substance metabolism
• • substance biosynthetic process:
• • • EXACT: substance anabolism
• • • EXACT: substance biosynthesis
• • • EXACT: substance formation
• • • EXACT: substance synthesis
• • substance catabolic process:
• • • EXACT: substance breakdown
• • • EXACT: substance catabolism
• • • EXACT: substance degradation

[pgaudet]

@lbreuza I presume you dont have the RHEA ID yet ? Please add it to the ticket when it becomes available (it just needs to be created, doesn't need to be public yet).

Thanks, Pascale

[lbreuza]

[like] Lionel Breuza reacted to your message:

…

________________________________ From: pgaudet ***@***.***> Sent: Thursday, December 19, 2024 3:02:33 PM To: geneontology/go-ontology ***@***.***> Cc: Lionel Breuza ***@***.***>; Mention ***@***.***> Subject: Re: [geneontology/go-ontology] NTR - metabolism: [U6 snRNA (guanine-N(2))-methyltransferase activity] (Issue #29482) @lbreuza<https://github.com/lbreuza> I presume you dont have the RHEA ID yet ? Please add it to the ticket when it becomes available (it just needs to be created, doesn't need to be public yet). Thanks, Pascale — Reply to this email directly, view it on GitHub<#29482 (comment)>, or unsubscribe<https://github.com/notifications/unsubscribe-auth/ADMGFHGRQIK52ST3UUSDNYL2GLNYTAVCNFSM6AAAAABT5BY35OVHI2DSMVQWIX3LMV43OSLTON2WKQ3PNVWWK3TUHMZDKNJUGQ4DCMJZGY>. You are receiving this because you were mentioned.Message ID: ***@***.***>

[lbreuza]

Will do. thanks

…

________________________________ From: pgaudet ***@***.***> Sent: Thursday, December 19, 2024 4:02 PM To: geneontology/go-ontology ***@***.***> Cc: Lionel Breuza ***@***.***>; Mention ***@***.***> Subject: Re: [geneontology/go-ontology] NTR - metabolism: [U6 snRNA (guanine-N(2))-methyltransferase activity] (Issue #29482) @lbreuza<https://github.com/lbreuza> I presume you dont have the RHEA ID yet ? Please add it to the ticket when it becomes available (it just needs to be created, doesn't need to be public yet). Thanks, Pascale — Reply to this email directly, view it on GitHub<#29482 (comment)>, or unsubscribe<https://github.com/notifications/unsubscribe-auth/ADMGFHGRQIK52ST3UUSDNYL2GLNYTAVCNFSM6AAAAABT5BY35OVHI2DSMVQWIX3LMV43OSLTON2WKQ3PNVWWK3TUHMZDKNJUGQ4DCMJZGY>. You are receiving this because you were mentioned.Message ID: ***@***.***>

[ValWood]

note to self check https://www.pombase.org/gene/SPBC25H2.10c is annotated as acetyltransferase by ISO. Looks suspect if THUMP is methyltransferase

[raymond91125]

+[Term]
+id: GO:0160230
+name: U6 snRNA (guanine-N(2))-methyltransferase activity
+namespace: molecular_function
+def: "Catalysis of the reaction: guanosine in U6 snRNA + S-adenosyl-L-methionine = H+ + N(2)-methylguanosine in U6 snRNA + S-adenosyl-L-homocysteine." [PMID:37283053]
+is_a: GO:0106346 ! snRNA methyltransferase activity
+property_value: term_tracker_item "#29482" xsd:anyURI
+created_by: rynl
+creation_date: 2024-12-26T18:27:41Z