Back to index of relations docs
---------------Text extracted from ontology: DO NOT EDIT---------------
- OWL ID: RO_0002356
- label: results in specification of
- synonyms []
The relationship linking a cell and its participation in a process that results in the fate of the cell being specified. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.
The relationship linking a cell and its participation in a process that results in the transition of a cell such that is can only develop into a single cell type when left in its environment.
Example of use: an annotation of gene X to cell determination with results_in_determination_of CL:0000540 (neuron) means that at the end of the process an unspecified cell will develop into a neuron if left in its environment. If the cell is moved, it may develop into a cell type other than a neuron.
[valid_for_annotation_extension, AE_cell_or_anatomical, display_for_curators]
##local domain {u'GO:0008150': u'biological_process'}
{u'CL:0000000': u'cell', u'WBbt:0004017': u'Cell'}
---------------END AUTO GENERATED SECTION---------------
Indicating the cell or cell type specified by the activity of a gene product
Statement from paper:
However, the strong loss-of-function allele of eya-1, ok654 (Furuya et al., 2005), displayed M lineage phenotypes similar to ceh-34(RNAi-P): loss of M-derived CCs and variable loss of embryonic CCs (Table 1, Fig. 3A). Thus, both ceh-34 and eya-1 are required for specifying the embryonic and M-derived CCs.
Note that in the above sentence, M refers to the M mesoblast and CCs refers to coelomocytes.
| Gene Name (col 2) | GO ID (col 5) | Reference (col 6) | Evidence (col 7) | With (col 8) | Annotation Extension (col 16) |
|---|---|---|---|---|---|
| Q94165 ceh-34 | GO:0007501 mesodermal cell fate specification | PMID:19427847 | IMP | WB:WBRNAi00101780 | results_in_specification_of(WBbt:0005751 coelomocyte) |
| O17670 eya-1 | GO:0007501 mesodermal cell fate specification | PMID:19427847 | IMP | WB:WBVar00091938 | results_in_specification_of(WBbt:0005751 coelomocyte) |
Using examples to demonstrate Folding_and_Unfolding using the relationship results_in_specification_of
Indicating the cell or cell type specified by the activity of a gene product
Statement from paper:
However, the strong loss-of-function allele of eya-1, ok654 (Furuya et al., 2005), displayed M lineage phenotypes similar to ceh-34(RNAi-P): loss of M-derived CCs and variable loss of embryonic CCs (Table 1, Fig. 3A). Thus, both ceh-34 and eya-1 are required for specifying the embryonic and M-derived CCs.
| Folded/unfolded | Gene Name (col 2) | GO ID (col 5) | Reference (col 6) | Evidence (col 7) | With (col 8) | Annotation Extension (col 16) | Parent terms of new folded GO term |
|---|---|---|---|---|---|---|---|
| Unfolded | Q94165 ceh-34 | GO:0007501 mesodermal cell fate specification | PMID:19427847 | IMP | WB:WBRNAi00101780 | results_in_specification_of(WBbt:0005751 coelomocyte) | |
| Unfolded | O17670 eya-1 | GO:0007501 mesodermal cell fate specification | PMID:19427847 | IMP | WB:WBVar00091938 | results_in_specification_of(WBbt:0005751 coelomocyte) | |
| Folded | Q94165 ceh-34 | GO:0007501 mesodermal cell fate specification resulting in specification of coelomocyte | PMID:19427847 | IMP | WB:WBRNAi00101780 | is_a mesodermal cell fate specification | |
| Folded | O17670 eya-1 | GO:0007501 mesodermal cell fate specification resulting in specification of coelomocyte | PMID:19427847 | IMP | WB:WBVar00091938 | is_a mesodermal cell fate specification | |
OWL class expression:
OWL class expression: GO:0007501 mesodermal cell fate specification results_in_specification_of SOME WBbt:0005751 coelomocyte
Back to index of relations docs