diff --git a/.gitignore b/.gitignore
index 97b2970..20c9383 100644
--- a/.gitignore
+++ b/.gitignore
@@ -10,3 +10,4 @@ htmlcov/
 /build
 /dist
 /cgp_seq_input_val.egg-info
+.vscode
\ No newline at end of file
diff --git a/CHANGES.md b/CHANGES.md
index a3c6bce..ecf5dcf 100644
--- a/CHANGES.md
+++ b/CHANGES.md
@@ -1,5 +1,9 @@
 # CHANGES
 
+## 1.4.1
+
+* `validator` now allows upper case in FastQ file name extensions
+
 ## 1.4.0
 
 * Correct base config for file types accepted.  File_2 should only accept `f(?:ast)q.gz` (upper/lower)
diff --git a/cgp_seq_input_val/seq_validator.py b/cgp_seq_input_val/seq_validator.py
index 0bf48e1..0be426d 100644
--- a/cgp_seq_input_val/seq_validator.py
+++ b/cgp_seq_input_val/seq_validator.py
@@ -94,7 +94,8 @@ def _prep(self):
             full_ext = ext
             (base, ext) = os.path.splitext(base)
 
-        if ext not in ('.fastq', '.fq'):
+        if ext.lower() not in ('.fastq', '.fq'):
+            # This check should be consistent with FastQ file extension restrictions in manifest.py
             raise SeqValidationError("Input files must be fastq|fq[.gz]")
 
         full_ext = ext + full_ext
diff --git a/setup.py b/setup.py
index 210c8c5..649d9fb 100755
--- a/setup.py
+++ b/setup.py
@@ -9,7 +9,7 @@
     'url': 'https://github.com/cancerit/cgp_seq_input_val',
     'download_url': '',
     'author_email': 'cgphelp@sanger.ac.uk',
-    'version': '1.4.0',
+    'version': '1.4.1',
     'python_requires': '>= 3.6',
     'setup_requires': ['pytest'],
     'install_requires': ['progressbar2', 'xlrd', 'xopen'],