Enrichment Analysis

[salhajh]

Hello.

I am analysing a set of WGS data, however some of the patients in the study have multiple variants in a single gene. I am looking to conduct an enrichment analysis using gnomAD data (preferably v3) as a control cohort, however I would need to account for individuals in gnomAD who may have multiple variants in a single gene. Is there a way to understand or detect how many patients would fall into that category for a set of genes?

Thank you.