diff --git a/.github/workflows/release.yml b/.github/workflows/release.yml
index 3576aba536..5c97203019 100644
--- a/.github/workflows/release.yml
+++ b/.github/workflows/release.yml
@@ -21,10 +21,10 @@ jobs:
     - name: Install build tools
       run: |
         python -m pip install --upgrade pip
-        python -m pip install --upgrade setuptools setuptools_scm wheel
+        python -m pip install --upgrade build setuptools setuptools_scm wheel
 
     - name: Build packages
-      run: python setup.py sdist bdist_wheel
+      run: python -m build
 
     - name: Save built packages as artifact
       uses: actions/upload-artifact@v4
diff --git a/docs/devel/infrastructureguide.rst b/docs/devel/infrastructureguide.rst
index add26dd622..4012cfc7fe 100644
--- a/docs/devel/infrastructureguide.rst
+++ b/docs/devel/infrastructureguide.rst
@@ -118,10 +118,10 @@ To build and upload manually (if for some reason it is necessary):
 2. (optional) Perform a ``git clean -f -x -d`` from the root of the repository. This will
    **delete** everything not tracked by git, but will also ensure clean source distribution.
    ``MANIFEST.in`` is set to include/exclude mostly correctly, but could miss some things.
-3. Run ``python setup.py sdist bdist_wheel`` (this requires that ``wheel`` is installed).
+3. Run ``python -m build`` (this requires that ``build`` is installed).
 4. Upload using ``twine``: ``twine upload dist/*``, assuming the ``dist/`` directory contains
    only files for this release. This upload process will include any changes to the ``README``
-   as well as any updated flags from ``setup.py``.
+   as well as any updated flags from ``pyproject.toml``.
 
 ~~~~~
 Conda
diff --git a/setup.py b/setup.py
deleted file mode 100644
index 261553a8a5..0000000000
--- a/setup.py
+++ /dev/null
@@ -1,22 +0,0 @@
-# Copyright (c) 2008,2010,2015,2016,2019 MetPy Developers.
-# Distributed under the terms of the BSD 3-Clause License.
-# SPDX-License-Identifier: BSD-3-Clause
-"""Setup script for installing MetPy."""
-
-import sys
-
-from setuptools import setup
-
-if sys.version_info[0] < 3:
-    error = """
-    If you're using Python 2.7, please install MetPy v0.11.1,
-    which is the last release of MetPy that supports Python 2.7,
-    but it is no longer maintained.
-
-    Python {py} detected.
-    """.format(py='.'.join(str(v) for v in sys.version_info[:3]))
-
-    print(error)  # noqa: T201
-    sys.exit(1)
-
-setup(use_scm_version={'version_scheme': 'post-release'})